Birth Prevalence of Orofacial Clefts in Kuwait From Hospital-Based Registration: Retrospective Study
Affiliations
Affiliations
- Riyadh College of Dentistry and Pharmacy (RCDP), Riyadh, Saudi Arabia.
- Ministry of Health (MoH), Kuwait City, Kuwait.
- Amiri Dental Center, Ministry of Health (MoH), Kuwait City, Kuwait.
Abstract
Introduction: Cleft lip and palate (CLAP) are the most common craniofacial anomalies and birth defects globally. Despite the fact that a tertiary care registry of clefts has existed in Kuwait since 2008, to date there is no published data regarding the prevalence of orofacial clefts in this population.
Objective: To tabulate the pattern of orofacial clefts from tertiary care center registration during 2009 through 2014 and to estimate the prevalence and trend using population-based records.
Methodology: Data from all CLAP cases (born in Kuwait) registered in the central cleft center registry of the Al-Amiri hospital, Kuwait City, Kuwait, from January 2009 to December 2014 were obtained. Data regarding the type, severity, gender as well as nationality, parental consanguinity, and associated syndrome were obtained from medical records. Birth prevalence was tabulated against the population statistics for the period obtained from the central department of statistics.
Result: A total of 202 CLAP patients were recorded in the study period with a mean birth prevalence of 0.57 per 1000 live births (95% confidence interval [CI] .57 ± .23). The registry recorded 108 (53.2%) males and 94 (47.8%) females. Children born to Kuwaitis represented 53.7% of cases while those born to non-Kuwaitis represented 45.3%. The most common oral cleft was CLAP (47.3%), followed by cleft palate (30.5%), cleft lip (20.2%), and other facial clefts (2%). Other congenital anomalies were recognized in 33% of all cases. There were no statistically significant differences in oral cleft prevalence across gender or nationality.
Conclusion: The prevalence of oral cleft in Kuwait appears to be similar to those of other Middle Eastern populations.
Keywords: Middle East; cleft lip and palate; epidemiology.
Similar articles
Doray B, Badila-Timbolschi D, Schaefer E, Fattori D, Monga B, Dott B, Favre R, Kohler M, Nisand I, Viville B, Kauffmann I, Bruant-Rodier C, Grollemund B, Rinkenbach R, Astruc D, Gasser B, Lindner V, Marcellin L, Flori E, Girard-Lemaire F, Dollfus H.Arch Pediatr. 2012 Oct;19(10):1021-9. doi: 10.1016/j.arcped.2012.07.002. Epub 2012 Aug 24.PMID: 22925539 French.
Shapira Y, Blum I, Haklai Z, Shpack N, Amitai Y.Community Dent Oral Epidemiol. 2018 Dec;46(6):586-591. doi: 10.1111/cdoe.12395. Epub 2018 Jun 29.PMID: 29956842
Paaske EB, Garne E.Eur J Med Genet. 2018 Sep;61(9):489-492. doi: 10.1016/j.ejmg.2018.05.016.PMID: 29753919
Kadir A, Mossey PA, Blencowe H, Moorthie S, Lawn JE, Mastroiacovo P, Modell B.Cleft Palate Craniofac J. 2017 Sep;54(5):571-581. doi: 10.1597/15-221. Epub 2016 Jul 19.PMID: 27440051 Review.
Allagh KP, Shamanna BR, Murthy GV, Ness AR, Doyle P, Neogi SB, Pant HB; Wellcome Trust- PHFI Folic Acid project team.PLoS One. 2015 Mar 13;10(3):e0118961. doi: 10.1371/journal.pone.0118961. eCollection 2015.PMID: 25768737 Free PMC article. Review.