Effect of repeated doses of dexamethasone on the incidence and severity of respiratory distress syndrome in multifetal gestation between 24 and 34 weeks
Affiliations
Affiliations
Department of Obstetrics and Gynecology, Faculty of Medicine, Kuwait University, Safat, Kuwait. sobha@hsc.kuniv.edu.kw
Abstract
The objective of the study was to evaluate the effects of antenatal corticosteroid therapy in multiple pregnancy on the incidence and severity of respiratory distress syndrome (RDS). Twenty-two women with twin, 12 with triplet and 2 with quadruplet pregnancies and an emergency group of 20 mothers with twin pregnancies, who only had one course of dexamethasone, were compared with controls. Corticosteroid therapy was associated with a reduction in moderate to severe RDS in all groups (twins p < 0.01, triplets and quadruplets p < 0.008) and the emergency group with dexamethasone therapy (p < 0.036) when compared to their individual controls. Dexamethasone reduced the duration of stay in the neonatal intensive care unit of the emergency twin group (p < 0.01). Neonatal birth weights were significantly less in all groups treated with repeated doses in comparison to the controls.
Similar articles
Choi SJ, Song SE, Seo ES, Oh SY, Kim JH, Roh CR.Aust N Z J Obstet Gynaecol. 2009 Apr;49(2):173-9. doi: 10.1111/j.1479-828X.2009.00970.x.PMID: 19432606
Antenatal Corticosteroids for the Prevention of Respiratory Distress Syndrome in Premature Twins.
Viteri OA, Blackwell SC, Chauhan SP, Refuerzo JS, Pedroza C, Salazar XC, Sibai BM.Obstet Gynecol. 2016 Sep;128(3):583-91. doi: 10.1097/AOG.0000000000001577.PMID: 27500336 Clinical Trial.
Perinatal outcome after multifetal reduction to twins compared with nonreduced multiple gestations.
Melgar CA, Rosenfeld DL, Rawlinson K, Greenberg M.Obstet Gynecol. 1991 Nov;78(5 Pt 1):763-7.PMID: 1923193
[Prevention of preterm birth complications by antenatal corticosteroid administration].
Schmitz T.J Gynecol Obstet Biol Reprod (Paris). 2016 Dec;45(10):1399-1417. doi: 10.1016/j.jgyn.2016.09.008. Epub 2016 Oct 21.PMID: 27776846 Review. French.
Use of antenatal corticosteroids in special circumstances: a comprehensive review.
Magann EF, Haram K, Ounpraseuth S, Mortensen JH, Spencer HJ, Morrison JC.Acta Obstet Gynecol Scand. 2017 Apr;96(4):395-409. doi: 10.1111/aogs.13104.PMID: 28130929 Review.
Cited by
Abbasalizadeh F, Pouya K, Zakeri R, Asgari-Arbat R, Abbasalizadeh S, Parnianfard N.Curr Clin Pharmacol. 2020;15(2):164-169. doi: 10.2174/1574884714666191007154936.PMID: 33070770 Free PMC article. Clinical Trial.
Multiple courses of antenatal steroids.
Sandesh Kiran PS, Dutta S, Narang A, Bhansali A, Malhi P.Indian J Pediatr. 2007 May;74(5):463-9. doi: 10.1007/s12098-007-0079-x.PMID: 17526958