Figure 1 The NEMA phantom (cold and hot spheres) and the transaxial image. NEMA = national electrical manufacturers association.

Figure 2 (A): Comparison of contrast for different reconstructing filters of a NEMA chest phantom: inclusive of 6 variable spheres (S1 and S2 are cold spheres) and (S3, S4, S5, and S6 are hot spheres), (B): Scattering plot for comparison of contrast for different reconstructing filters of the same NEMA phantom and the embedded spheres. NEMA = national electrical manufacturers association.

Figure 3 A 53 years old male patient with the history of CAD was refereed to NM for evaluation of myocardial perfusion post CABG. (A): Angiography result reported triple vessels disease, (B): Butterworth reconstructed SPECT results reported mild degree of ischemia in apex, (C): Wiener reconstructed SPECT results suggested severe diffuse uptake in anterior and anterolateral walls with moderate diffuse uptake in apex that was more consistent with angiography. CABG = coronary artery bypass grafting, CAD = coronary artery disease, SPECT = single photon emission computerized tomography.

Figure 4 A 41 years old male patient with atypical chest pain and shortness of breath was refereed to NM for assessment of possible CAD. (A): CT-angiography result reported Normal (LMCA, LAD, Diag, Circ, and RCA are normal), (B): Butterworth reconstructed SPECT results reported normal, (C): Wiener reconstructed SPECT results suggested normal with very mild diffuse uptake in basal anterolateral wall and inferior wall (likely due to diaphragmatic attenuation). Both reports were consistent with the CT-angiography. CAD = coronary artery disease, Circ = circumflex, CT = computerized tomography, Diag = diagonal, LAD = left anterior descending artery, LMCA = left main coronary artery, RCA = right coronary artery, SPECT = single photon emission computerized tomography.

Figure 5 A 62 years old female patient with atypical chest pain and history of multiple PCI was referred to NM for evaluation of myocardial perfusion. (A): Angiography result reported triple vessels disease, (B): Butterworth reconstructed SPECT results reported negative myocardial ischemia, (C): Wiener reconstructed SPECT results suggested diffuse uptake in inferior wall, apical and mid anterolateral walls + cardiomyopathy in septal wall that was more consistent with the angiography. PCI = percutaneous coronary intervention, SPECT = single photon emission computerized tomography.