Primary immunodeficiency disorders in Kuwait: first report from Kuwait National Primary Immunodeficiency Registry (2004--2006)

Waleed Al-Herz 1

Affiliations

01 March 2008

-

doi: 10.1007/s10875-007-9144-5

Abstract

Primary immunodeficiency disorders are heterogeneous group of illnesses that predispose patients to serious complications. Registries for these disorders have provided important epidemiological data and shown both racial and geographical variations. The clinical features of 76 patients with primary immunodeficiency disorders registered in Kuwait National Primary Immunodeficiency Registry from 2004 to 2006 were recorded. Ninety-eight percent of the patients presented in childhood. The prevalence of these disorders in children was 11.98 in 100,000 children with an incidence of 10.06 in 100,000 children. The distribution of these patients according to each primary immunodeficiency category is: combined T and B cell immunodeficiencies (21%), predominantly antibody immunodeficiency (30%), other well defined immunodeficiencies (30%), diseases of immune dysregulation (7%), congenital defects of phagocyte number, function or both (8%), and complement deficiencies (4%). The consanguinity rate within the registered patients was 77%. The patients had a wide range of clinical features affecting different body systems. Primary immunodeficiency disorders are prevalent in Kuwait and have a significant impact into the health system.

Figures

Fig. 1 Distribution of primary immunodeficiency disorders in Kuwait.

Fig. 1 Distribution of primary immunodeficiency disorders in Kuwait.

Fig. 2 Frequency of system involvement in patients with primary immunodeficiency in Kuwait.

Fig. 2 Frequency of system involvement in patients with primary immunodeficiency in Kuwait.

Fig. 3 System involvement per category of patients with primary immunodeficiency.

Fig. 3 System involvement per category of patients with primary immunodeficiency.

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