The Association of Vitamin D Receptor Polymorphisms with Multiple Sclerosis in a Case-Control Study from Kuwait
Affiliations
Affiliations
- Human Genetics Unit, Department of Pathology, Faculty of Medicine, Kuwait University, Jabriya, Kuwait.
- Pathology Master's Program, Department of Pathology, Faculty of Medicine, Kuwait University, Jabriya, Kuwait.
- Molecular Pathology Unit, Department of Pathology, Faculty of Medicine, Kuwait University, Jabriya, Kuwait.
Abstract
Vitamin D deficiency is associated with several diseases including multiple sclerosis (MS). Several factors influence vitamin D levels and its optimal multi-function maintenance. Our objective was to assess quantifiable variables influencing vitamin D level and metabolism in MS patients from Kuwait. In a case-control study involving 50 MS patients, and 50 healthy control individuals for which plasma vitamin D levels, supplement use, vitamin D receptor (VDR) variants, and skin pigmentation indices were ascertained; we found overall vitamin D levels to be deficient in both groups, and supplement use to be common practice. VDR variants TaqI and BsmI associated with MS risk, and ApaI associated with low disease progression. VDR variant FokI associated with higher vitamin D levels in both groups. We conclude that several quantifiable variables related to vitamin D associate with MS suggesting a possible clinical immuno-modulatory application of vitamin D for MS patients in Kuwait.
Conflict of interest statement
Competing Interests: The authors have declared that no competing interests exist.
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KMEL References
References
-
- VanAmerongen BM, Dijkstra CD, Lips P, Polman CH. Multiple sclerosis and vitamin D: an update. Eur J Clin Nutr. 2004. August;58(8):1095–109. . Epub 2004/04/01. eng. - PubMed
-
- al-Din AS, Khogali M, Poser CM, al-Nassar KE, Shakir R, Hussain J, et al. Epidemiology of multiple sclerosis in Arabs in Kuwait: a comparative study between Kuwaitis and Palestinians. Journal of the neurological sciences. 1990. December;100(1–2):137–41. . - PubMed
-
- Webb AR. Who, what, where and when-influences on cutaneous vitamin D synthesis. Prog Biophys Mol Biol. 2006. September;92(1):17–25. . Epub 2006/06/13. eng. - PubMed
-
- Uitterlinden AG, Fang Y, van Meurs JB, van Leeuwen H, Pols HA. Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states. J Steroid Biochem Mol Biol. 2004. May;89-90(1–5):187–93. . Epub 2004/07/01. eng. - PubMed
-
- Laaser U, Senault R, Viefhues H, Deutsche Gesellschaft für Sozialmedizin., Deutsches Institut zur Bekämpfung des Hohen Blutdruckes. Primary health care in the making Berlin; New York: Springer-Verlag; 1985. xxiv, 545 p. p.
-
- Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. The Journal of clinical endocrinology and metabolism. 2011. July;96(7):1911–30. 10.1210/jc.2011-0385 - DOI - PubMed
-
- Nessvi S, Johansson L, Jopson J, Stewart A, Reeder A, McKenzie R, et al. Association of 25-hydroxyvitamin D3)levels in adult New Zealanders with ethnicity, skin color and self-reported skin sensitivity to sun exposure. Photochem Photobiol. 2011. Sep-Oct;87(5):1173–8. Epub 2011/06/18. eng. 10.1111/j.1751-1097.2011.00956.x - DOI - PubMed
-
- Durrin LK, Haile RW, Ingles SA, Coetzee GA. Vitamin D receptor 3'-untranslated region polymorphisms: lack of effect on mRNA stability. Biochim Biophys Acta. 1999. March 30;1453(3):311–20. . Epub 1999/04/02. eng. - PubMed
-
- Narooie-Nejad M, Moossavi M, Torkamanzehi A, Moghtaderi A, Salimi S. Vitamin D Receptor Gene Polymorphism and the Risk of Multiple Sclerosis in South Eastern of Iran. J Mol Neurosci. 2015. February 18 . Epub 2015/04/10. Eng. - PubMed
-
- Narooie-Nejad M, Moossavi M, Torkamanzehi A, Moghtaderi A. Positive association of vitamin D receptor gene variations with multiple sclerosis in South East Iranian population. Biomed Res Int. 2015;2015:427519 Pubmed Central PMCID: 4320885. Epub 2015/02/17. eng. 10.1155/2015/427519 - DOI - PMC - PubMed
-
- Ben-Selma W, Ben-Fredj N, Chebel S, Frih-Ayed M, Aouni M, Boukadida J. Age- and gender-specific effects on VDR gene polymorphisms and risk of the development of multiple sclerosis in Tunisians: a preliminary study. Int J Immunogenet. 2015. April 20. - PubMed
-
- Tajouri L, Ovcaric M, Curtain R, Johnson MP, Griffiths LR, Csurhes P, et al. Variation in the vitamin D receptor gene is associated with multiple sclerosis in an Australian population. J Neurogenet. 2005. Jan-Mar;19(1):25–38. . Epub 2005/08/04. eng. - PubMed
-
- Fukazawa T, Yabe I, Kikuchi S, Sasaki H, Hamada T, Miyasaka K, et al. Association of vitamin D receptor gene polymorphism with multiple sclerosis in Japanese. J Neurol Sci. 1999. June 15;166(1):47–52. . Epub 1999/08/28. eng. - PubMed
-
- Dickinson JL, Perera DI, van der Mei AF, Ponsonby AL, Polanowski AM, Thomson RJ, et al. Past environmental sun exposure and risk of multiple sclerosis: a role for the Cdx-2 Vitamin D receptor variant in this interaction. Mult Scler. 2009. May;15(5):563–70. Epub 2009/04/23. eng. 10.1177/1352458509102459 - DOI - PubMed
-
- Sioka C, Papakonstantinou S, Markoula S, Gkartziou F, Georgiou A, Georgiou I, et al. Vitamin D receptor gene polymorphisms in multiple sclerosis patients in northwest Greece. J Negat Results Biomed. 2011;10:3 Pubmed Central PMCID: 3097159. Epub 2011/05/07. eng. 10.1186/1477-5751-10-3 - DOI - PMC - PubMed
-
- Garcia-Martin E, Agundez JA, Martinez C, Benito-Leon J, Millan-Pascual J, Calleja P, et al. Vitamin D3 receptor (VDR) gene rs2228570 (Fok1) and rs731236 (Taq1) variants are not associated with the risk for multiple sclerosis: results of a new study and a meta-analysis. PLoS One. 2013;8(6):e65487 Pubmed Central PMCID: 3688728. Epub 2013/07/11. eng. 10.1371/journal.pone.0065487 - DOI - PMC - PubMed
-
- Agliardi C, Guerini FR, Saresella M, Caputo D, Leone MA, Zanzottera M, et al. Vitamin D receptor (VDR) gene SNPs influence VDR expression and modulate protection from multiple sclerosis in HLA-DRB1*15-positive individuals. Brain Behav Immun. 2011. October;25(7):1460–7. Epub 2011/06/15. eng. 10.1016/j.bbi.2011.05.015 - DOI - PubMed
-
- Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP. Genetics and biology of vitamin D receptor polymorphisms. Gene. 2004. September 1;338(2):143–56. . Epub 2004/08/19. eng. - PubMed
-
- Christensen MH, Apalset EM, Nordbo Y, Varhaug JE, Mellgren G, Lien EA. 1,25-dihydroxyvitamin D and the vitamin D receptor gene polymorphism Apa1 influence bone mineral density in primary hyperparathyroidism. PLoS One. 2013;8(2):e56019 Pubmed Central PMCID: 3572149. Epub 2013/02/19. eng. 10.1371/journal.pone.0056019 - DOI - PMC - PubMed
-
- Whitfield GK, Remus LS, Jurutka PW, Zitzer H, Oza AK, Dang HT, et al. Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene. Mol Cell Endocrinol. 2001. May 25;177(1–2):145–59. . Epub 2001/05/30. eng. - PubMed
-
- Hagenau T, Vest R, Gissel TN, Poulsen CS, Erlandsen M, Mosekilde L, et al. Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis. Osteoporos Int. 2009. January;20(1):133–40. Epub 2008/05/07. eng. 10.1007/s00198-008-0626-y - DOI - PubMed