Helicobacter pylori-associated chronic antral gastritis in Kuwait - A histopathological study
Affiliations
Affiliations
- Department of Pathology, Faculty of Medicine, Kuwait University, Mubarak Al-Kabeer Hospital, Kuwait.
Abstract
In order to study the causal relationship between Helicobacter pylori (HP) and various inflammatory reactions in gastric antral mucosa, we have reviewed 268 endoscopic gastric biopsies in the Department of Pathology of Mubarak Al-Kabeer Teaching Hospital in Kuwait. Of the 219 HP-positive biopsies, 95.4% showed chronic gastritis (CG), 59.8% active chronic gastritis (ACG) and 78.5% lymphoid hyperplasia (LH). The prevalence of LH, CG or ACG, either alone or in combination, increased with increasing density (grade) of HP colonization, assuming statistical significance for LH and ACG (P<0.05), especially when these changes in Grade 1 HP cases were compared to those of Grade 2 and 3 combined. Moreover, the grade of LH by itself also showed statistically significant correlation (P<0.01) with the grade of inflammation. Our results confirm a causal relationship between HP colonization of gastric mucosa and the various forms of gastritis, and also provide evidence in support of induction of mucosa-associated lymphoid tissue (MALT) by HP, an observaion which may have significance in the genesis of gastric MALTomas.
Similar articles
[Helicobacter pylori gastritis: a new infectious disease. Reflections from personal experience].
Schmitt J, de Korwin JD, Faure G, Duprez A.Ann Gastroenterol Hepatol (Paris). 1991 Oct;27(5):219-21.PMID: 1746875 French.
Distinct B-cell clonal bands in Helicobacter pylori gastritis with lymphoid hyperplasia.
Saxena A, Moshynska O, Kanthan R, Bhutani M, Maksymiuk AW, Lukie BE.J Pathol. 2000 Jan;190(1):47-54. doi: 10.1002/(SICI)1096-9896(200001)190:1<47::AID-PATH506>3.0.CO;2-O.PMID: 10640991
Kekki M, Maaroos HI, Sipponen P, Uibo R, Tammur R, Tamm A, Villako K.Scand J Gastroenterol Suppl. 1991;186:142-50.PMID: 1759122
Helicobacter pylori infection and gastric MALTomas: an up-to-date and therapy highlight.
Santacroce L, Cagiano R, Del Prete R, Bottalico L, Sabatini R, Carlaio RG, Prejbeanu R, Vermesan H, Dragulescu SI, Vermesan D, Motoc A, Losacco T.Clin Ter. 2008 Nov-Dec;159(6):457-62.PMID: 19169609 Review.
Helicobacter pylori, gastritis, and ulcers in pediatrics.
Judd RH.Adv Pediatr. 1992;39:283-306.PMID: 1442315 Review.
Cited by
Seroprevalence of Helicobacter pylori among children in Sana'a, Yemen.
Al-Shamahy HA.Ann Saudi Med. 2005 Jul-Aug;25(4):299-303. doi: 10.5144/0256-4947.2005.299.PMID: 16212122 Free PMC article.