In-hospital mortality in SARS-CoV-2 stratified by serum 25-hydroxy-vitamin D levels: A retrospective study

Mohammed Al-Jarallah 1, Rajesh Rajan 1, Raja Dashti 1, Ahmad Al Saber 2, Jiazhu Pan 2, Kobalava D Zhanna 3, Hassan Abdelnaby 4, Wael Aboelhassan 5, Farah Almutairi 6, Mohammed Abdullah 7, Naser Alotaibi 8, Mohammad Al Saleh 6, Noor Al Nasrallah 8, Bader Al-Bader 6, Haya Malhas 9, Maryam Ramadhan 10, Mahdy Hamza 11, Peter A Brady 12, Ibrahim Al-Zakwani 13, Moudhi Alroomi 7

Affiliations

10 January 2021

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doi: 10.1002/jmv.27133

Abstract

This study is done to estimаte in-hоsрitаl mоrtаlity in раtients with severe асute resрirаtоry syndrоme соrоnаvirus 2 (SАRS-СоV-2) strаtified by Vitamin-D (Vit-D) levels. Раtients were strаtified ассоrding tо by serum 25-hydroxy-vitamin D (25(OH)Vit-D) levels intо twо grоuрs, that is, 25(OH)Vit-D less thаn 40 nmol/L аnd 25(OH)Vit-D greаter thаn 40 nmol/L. А tоtаl оf 231 раtients were inсluded. Оf these, 120 (50.2%) оf the раtients hаd 25(OH)Vit-D levels greаter thаn 40 nmol/L. The meаn аge wаs 49 ± 17 yeаrs, аnd 67% оf the раtients were mаles. The mediаn length оf оverаll hоsрitаl stаy wаs 18 [6; 53] dаys. The remаining 119 (49.8%) раtients hаd а 25(OH)Vit-D less thаn 40 nmol/L. Vitamin D levels were seen as deficient in 63% of patients, insufficient in 25% and normal in 12%. Оverаll mоrtаlity wаs 17 раtients (7.1%) but statistically not signifiсаnt among the grоuрs (p = 0.986). The Kарlаn-Meier survivаl аnаlysis shоwed no significance based on an alpha of 0.05, LL = 0.36, df = 1, p = 0.548, indicating Vitamin_D_Levels was not able to adequately predict the hazard of Mortality. In this study, serum 25(OH)Vit-D levels were found have no significance in terms of predicting the in-hоsрitаl mortality in раtients with SАRS-СоV-2.

Keywords: COVID-19; SARS-CoV-2; in-hospital mortality; vitamin D.

Figures

Figure 1 Kaplan–Meier survival plot of mortality grouped by Vitamin_D_Levels

Figure 1 Kaplan–Meier survival plot of mortality grouped by Vitamin_D_Levels

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References

  1.  
    1. Ricci A, Pagliuca A, D'ascanio M, et al. Circulating vitamin D levels status and clinical prognostic indices in COVID‐19 patients. Respir Res. 2021;22:76. - PMC - PubMed
  2.  
    1. Raharusun P, Priambada S, Budiarti C, et al. Patterns of COVID‐19 mortality and vitamin D: an Indonesian study. 2020. https://ssrn.com/abstract=3585561
  3.  
    1. Jain A, Chaurasia R, Sengar NS, Singh M, Mahor S, Narain S. Analysis of vitamin D level among asymptomatic and critically ill COVID‐19 patients and its correlation with inflammatory markers. Sci Rep. 2020;10:20191. - PMC - PubMed
  4.  
    1. Carpagnano GE, Di Lecce V, Quaranta VN, et al. Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID‐19. J Endocrinol Invest. 2021;44:765‐771. - PMC - PubMed
  5.  
    1. Vo P, Koppel C, Espinola JA, et al. Vitamin D status at the time of hospitalization for bronchiolitis and its association with disease severity. J Pediatr. 2018;203:416‐422. - PubMed
  6.  
    1. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta‐analysis of individual participant data. Br Med J. 2017;356:i6583. - PMC - PubMed
  7.  
    1. Mamani M, Muceli N, Ghasemi Basir HR, Vasheghani M, Poorolajal J. Association between serum concentration of 25‐hydroxyvitamin D and community‐acquired pneumonia: a case‐control study. Int J Gen Med. 2017;13(10):423‐429. - PMC - PubMed
  8.  
    1. Ross AC, Manson JE, Abrams SA, et al. The report on dietary reference intakes for calcium and vitamin D from the institute of medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96(2011):53‐58. - PMC - PubMed
  9.  
    1. Thomas L, Reyes EM. Tutorial: survival estimation for Cox regression models with time‐varying coefficients using SAS and R. J Stat Softw. 2014;61:1‐23.
  10.  
    1. Hastie CE, Mackay DF, Ho F, et al. Vitamin D concentrations and COVID‐19 infection in UK Biobank. Diabetes Metab Syndr. 2020;14:561‐565. - PMC - PubMed
  11.  
    1. Herr C, Shaykhiev R, Bals R. The role of cathelicidin and defensins in pulmonary inflammatory diseases. Expert Opin Biol Ther. 2007;7:1449‐1461. - PubMed
  12.  
    1. Goncalves‐Mendes N, Talvas J, Dualé C, et al. Impact of Vitamin D supplementation on influenza vaccine response and immune functions in deficient elderly persons: a randomized placebo‐controlled trial. Front Immunol. 2019;10:65. - PMC - PubMed
  13.  
    1. Iwasaki A, Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science. 2010;327:291‐295. - PMC - PubMed
  14.  
    1. Naghavi Gargari B, Behmanesh M, Shirvani Farsani Z, Pahlevan Kakhki M, Azimi AR. Vitamin D supplementation up‐regulates IL‐6 and IL‐17A gene expression in multiple sclerosis patients. Int Immunopharmacol. 2015;28:414‐419. 10.1016/j.intimp.2015.06.033 - DOI - PubMed
  15.  
    1. Omdahl JL, Garry PJ, Hunsaker LA, Hunt WC, Goodwin JS. Nutritional status in a healthy elderly population: vitamin D. Am J Clin Nutr. 1982;36(6):1225‐1233. - PubMed
  16.  
    1. Baktash V, Hosack T, Patel N, et al. Vitamin D status and outcomes for hospitalised older patients with COVID‐19. Postgrad Med J. 2020. 10.1136/postgradmedj-2020-138712 - DOI - PMC - PubMed
  17.  
    1. Laird E, Rhodes J, Kenny RA. Vitamin D and inflammation: potential implications for severity of covid‐19. Ir Med J. 2020;113(5):81. - PubMed
  18.  
    1. Merzon E, Tworowski D, Gorohovski A, et al. Low plasma 25(OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based study. FEBS J. 2020;10:15495‐3702. 10.1111/febs.15495 - DOI - PMC - PubMed
  19.  
    1. Pizzini A, Aichner M, Sahanic S, et al. Impact of vitamin D deficiency on COVID‐19—a prospective analysis from the CovILD registry. Nutrients. 2020;12:E2775. 10.3390/nu12092775 - DOI - PMC - PubMed
  20.  
    1. Annweiler C, Hanotte B, de l'Eprevier CG, Sabatier JM, Lafaie L, Célarier T. Vitamin D and survival in COVID‐19 patients: a quasi‐experimental study. J Steroid Biochem Mol Biol. 2020;204:105771. 10.1016/j.jsbmb.2020.105771 - DOI - PMC - PubMed
  21.  
    1. Castillo ME, Entrenas Costa LM, Vaquero Barrios JM, et al. Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID‐19: a pilot randomized clinical study. J Steroid Biochem Mol Biol. 2020;29:10575. - PMC - PubMed
  22.  
    1. Entrenas CM, Entrenas CL, Vaquero BJ, Alcalá DJ, López MJ, et al. Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID‐19: A pilot randomized clinical study. J Steroid Biochem Mol Biol. 2020:203105751. - PMC - PubMed

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