Classical Presentation of Acute Pyelonephritis in a Case of Brucellosis

Wadha Alfouzan 1, Sara Al-Sahali 2, Hawra'a Sultan 3, Rita Dhar 2

Affiliations

06 October 2016

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doi: 10.1159/000446393

Abstract

Although Brucella species is known to affect almost all organs in humans, renal involvement presenting as acute pyelonephritis remains a rare entity in brucellosis. We report the case of a female patient who presented with symptoms of fever with chills, right loin pain and dysuria in the emergency room. Blood cultures drawn at the time of admission grew Brucella spp., but no organisms were isolated from urine culture although urinalysis data was indicative of urinary tract infection. Empiric therapy with piperacillin/tazobactam plus gentamicin relieved her symptoms. However, the treatment was switched to doxycycline plus rifampicin once the blood culture result was obtained.

Keywords: Acute pyelonephritis; Bacteremia; Brucella spp.; Brucellosis.

Figures

Fig. 1. Right kidney showing double moiety manifested as two partially separated collecting systems (arrows).

Fig. 1. Right kidney showing double moiety manifested as two partially separated collecting systems (arrows).

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References

  1.  
    1. Dean AS, Crump L, Greter H, Hattendorf J, Schelling E, Zinsstag J. Clinical manifestations of human brucellosis: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2012;69:1–9. - PMC - PubMed
  2.  
    1. Shimal SB, Dukhan L, Belmaker S, Barrett C, Greenberg D. Human brucellosis outbreak acquired through camel milk ingestion in Southern Israel. Isr Med Assoc J. 2012;14:475–478. - PubMed
  3.  
    1. Traxler RM, Lehman MW, Bosserman EA, Guerra MA, Smith TL. A literature review of laboratory-acquired brucellosis. J Clin Microbiol. 2013;51:3055–3062. - PMC - PubMed
  4.  
    1. Sathyanarayanan V, Razak A, Savaru K, Ananthakrishnan SB, Mukhyprana PM, Vandana KE. Clinical profile of brucellosis from a tertiary care center in Southern India. Asian Pac J Trop Med. 2011:397–400. - PubMed
  5.  
    1. Guler S, Kokoglu OF, Ucmak H, Gul M, Ozden S, Ozkan F. Human brucellosis in Turkey: different clinical presentations. J Infect Dev Ctries. 2014;8:581–588. - PubMed
  6.  
    1. Buzgan T, Karahocagil MK, Irmak H, Baran AI, Karsen H, Evirgen O, Akdeniz H. Clinical manifestations and complications in 1,028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J Infect Dis. 2010;14:469–478. - PubMed
  7.  
    1. Mohamed ZJ, Bee Yong T, Hashim R, Mohamed NA, Hamzah SH, Ahmad N. Identification of Brucella spp. isolated from human brucellosis in Malaysia using high-resolution melt (HRM) analysis. Diagn Microbiol Infect Dis. 2015;81:227–233. - PubMed
  8.  
    1. Al-Nakkas A, Mustafa AS, Wright SG. Large scale evaluation of a single-tube nested PCR for the laboratory diagnosis of human brucellosis in Kuwait. J Med Microbiol. 2005;54(Pt 8):727–730. - PubMed
  9.  
    1. Franco MP, Mulder M, Gilman RH, Smits HL. Human brucellosis. Lancet Infect Dis. 2007;7:775–786. - PubMed
  10.  
    1. Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med. 2005;352:2325–2336. - PubMed
  11.  
    1. Khateeb MI, Araj GF, Majeed SA, Lulu AR. Brucella arthritis: a study of 96 cases in Kuwait. Ann Rheum Dis. 1990;49:994–998. - PMC - PubMed
  12.  
    1. Lulu AR, Araj GF, Khateeb MI, Mustafa MY, Yusuf AR, Fenech FF. Human brucellosis in Kuwait: a prospective study of 400 cases. Q J Med. 1988;66:39–54. - PubMed
  13.  
    1. Erdem H, Elaldi N, Ak O, Gulsun S, Tekin R, Ulug M, Duygu F, Sunnrtcioglu M, Tulek N, Guler S, Cag Y, Kaya S, et al. Genitourinary brucellosis: results of a multicentric study. Clin Microbiol Infect. 2014;20:O847–O853. - PubMed
  14.  
    1. Dhar R, Dhar PM, Gafoor M. Recurrent epidermal cyst infection caused by Brucella melitensis in a diabetic patient. J Clin Microbiol. 1988;26:1040–1041. - PMC - PubMed
  15.  
    1. Meltzer E, Sidi Y, Smolen G, Banai M, Bardenstein S, Schwartz E. Sexually transmitted brucellosis in humans. Clin Infect Dis. 2010;51:e12–e15. - PubMed

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