False-positive (111)In-pentetreotide Uptake in Gastritis

Sharjeel Usmani 1, Alshaima Alshammari 2

Affiliations

01 May 2013

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doi: 10.4103/1450-1147.136699

Abstract

(111)In-pentetreotide [(111)In-octreoscan] is the most widely used radiolabeled somatostatin analog for evaluating neuroendocrine tumor overexpression of somatostatin receptors. False-positives studies of somatostatin receptor scintigraphy have been reported and often the cause is unexplained but assumed to be due to high number of somatostatin receptors in other pathologies. Causes of false-positives include visualization of the gallbladder, nasal mucosa and pulmonary hilar areas in respiratory infections, thyroid abnormalities, accessory spleens, recent Cerebrovascular accidents (CVA's) and activity at the site of a recent surgical incision. In infection or inflammation the cause of false-positive uptake is probably the result of tracer binding by somatostatin receptors on the inflammatory leukocytes. In this case report, we report, a 44-year-old male patient with false-positive (111)In-pentetreotide uptake due to gastritis.

Keywords: 111In-pentetreotide; false positive; gastritis.

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1 Core biopsy of right axilla suggested that the mass is most likely metastatic rather than a primary lesion with a degree of neuroendocrine differentiation suggesting primary lung or gastrointestinal origin

Figure 1 Core biopsy of right axilla suggested that the mass is most likely metastatic rather than a primary lesion with a degree of neuroendocrine differentiation suggesting primary lung or gastrointestinal origin

Figure 2 111In-pentetreotide whole body imaging (a), spot views (b) and single-photon emission computed tomography (c) revealed a large focal area of increased tracer uptake at the right axilla. Diffuse increased tracer uptake seen at the left upper abdomen in the region of the stomach was also noted

Figure 2 111In-pentetreotide whole body imaging (a), spot views (b) and single-photon emission computed tomography (c) revealed a large focal area of increased tracer uptake at the right axilla. Diffuse increased tracer uptake seen at the left upper abdomen in the region of the stomach was also noted

Figure 3 (a and b) Biopsies revealed chronic active Helicobacter pylori associated gastritis

Figure 3 (a and b) Biopsies revealed chronic active Helicobacter pylori associated gastritis

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References

  1.  
    1. Solcia E, Klöppel G, Sobin LH. Histological typing of endocrine tumours. In: Solcia E, Klöppel G, Sobin LH, editors. International Histological Classification of Tumours. 2nd ed. Berlin Germany: Springer-Verlag; 2000. pp. 61–8.
  2.  
    1. John M, Meyerhof W, Richter D, Waser B, Schaer JC, Scherübl H, et al. Positive somatostatin receptor scintigraphy correlates with the presence of somatostatin receptor subtype 2. Gut. 1996;38:33–9. - PMC - PubMed
  3.  
    1. Zimmer T, Ziegler K, Bäder M, Fett U, Hamm B, Riecken EO, et al. Localisation of neuroendocrine tumours of the upper gastrointestinal tract. Gut. 1994;35:471–5. - PMC - PubMed
  4.  
    1. Yim JH, Siegel BA, DeBenedetti MK, Norton JA, Lairmore TC, Doherty GM. Prospective study of the utility of somatostatin-receptor scintigraphy in the evaluation of patients with multiple endocrine neoplasia type 1. Surgery. 1998;124:1037–42. - PubMed
  5.  
    1. Alexander HR, Fraker DL, Norton JA, Bartlett DL, Tio L, Benjamin SB, et al. Prospective study of somatostatin receptor scintigraphy and its effect on operative outcome in patients with Zollinger-Ellison syndrome. Ann Surg. 1998;228:228–38. - PMC - PubMed
  6.  
    1. Gibril F, Reynolds JC, Chen CC, Yu F, Goebel SU, Serrano J, et al. Specificity of somatostatin receptor scintigraphy: A prospective study and effects of false-positive localizations on management in patients with gastrinomas. J Nucl Med. 1999;40:539–53. - PubMed
  7.  
    1. Castellani M, Reschini E, Gasparini M, Gerundini P. Indium-111 pentetreotide lung uptake in infectious lung disease. Clin Nucl Med. 1999;24:343–5. - PubMed
  8.  
    1. Yenson T, Khalil T, Larcos G. Pneumonia can cause 111indium octreotide uptake. Australas Radiol. 2006;50:218–21. - PubMed

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