Abstract

Ga-68 PSMA is a promising radiotracer for both staging and detection of biochemical recurrence in prostate cancer. PSMA is also expressed in the endothelium of tumour-associated neo vasculature of various solid malignancies possibly due to tumour-associated angiogenic factors and endothelial cell sprouting. We report a case of 72-yearold male with known prostate cancer on follow-up with mild increase in serum PSA level. 68Ga-PSMA PET-CT showed large PSMA avid mass in the left thyroid lobe, histopathology revealed papillary carcinoma. 68Ga-PSMA expression in the thyroid carcinoma potentially guide to radionuclide legend therapy with α/β- emitters specially in iodine refractory cases.

Keywords: 68Ga-PSMA PET-CT; angiogenesis; PET/CT; thyroid carcinoma.