Neutrophil to lymphocyte ratio and in-hospital mortality among patients with SARS-CoV-2: A retrospective study

Maryam Salah Al-Mazedi 1, Rajesh Rajan 2, Mohammed Al-Jarallah 2, Raja Dashti 2, Ahmad Al Saber 3, Jiazhu Pan 3, Kobalava D Zhanna 4, Hassan Abdelnaby 5, Wael Aboelhassan 6, Farah Almutairi 7, Naser Alotaibi 8, Mohammad Al Saleh 7, Noor AlNasrallah 8, Bader Al-Bader 7, Haya Malhas 9, Maryam Ramadhan 10, Peter A Brady 11, Ibrahim Al-Zakwani 12, Parul Setiya 13, Mohammed Abdullah 14, Moudhi Alroomi 14, Gary Tse 15

Affiliations

10 January 2022

-

doi: 10.1016/j.amsu.2022.104748

Abstract

The goal of this study was to investigate in-hospital mortality in patients suffering from acute respiratory syndrome coronavirus 2 (SARS-CoV-2) relative to the neutrophil to lymphocyte ratio (NLR) and to determine if there are gender disparities in outcome. Between February 26 and September 8, 2020, patients having SARS-CoV-2 infection were enrolled in this retrospective cohort research, which was categorized by NLR levels ≥9 and < 9. In total, 6893 patients were involved included of whom6591 had NLR <9, and 302 had NLR ≥9. The age of most of the patients in the NLR<9 group was 50 years, on the other hand, the age of most of the NLR ≥9 group patients was between 50 and 70 years. The majority of patients in both groups were male 2211 (66.1%). The ICU admission time and mortality rate for the patients with NLR ≥9 was significantly higher compared to patients with NLR <9. Logistic regression's outcome indicated that NLR ≥9 (odds ratio (OR), 24.9; 95% confidence interval (CI): 15.5-40.0; p < 0.001), male sex (OR, 3.5; 95% CI: 2.0-5.9; p < 0.001) and haemoglobin (HB) (OR, 0.95; 95% CI; 0.94-0.96; p < 0.001) predicted in-hospital mortality significantly. Additionally, Cox proportional hazards analysis (B = 4.04, SE = 0.18, HR = 56.89, p < 0.001) and Kaplan-Meier survival probability plots also indicated that NLR>9 had a significant effect on mortality. NLR ≥9 is an independent predictor of mortality(in-hospital) among SARS-CoV-2 patients.

Keywords: AОR, аdjusted Odds Rаtiо; COVID-19; ICU, Intensive Care Unit; In-hospital mortality; NLR; NLR, Neutrophil to lymphocyte ratio; RT–PCR, Reverse Transcription Polymerase Chain Reaction; SARS-CoV-2; SАRS-СоV-2, severe асute resрirаtоry syndrоme соrоnаvirus 2; СI, Cоnfidenсe Intervаl; СRF, Cаse Reсоrd Fоrm.

Conflict of interest statement

Nothing to disclose.

Figures

Fig. 1 Kaplan-Meier survival plot of Mortality grouped by neutrophil to lymphocyte ratio (NLR).

Fig. 1 Kaplan-Meier survival plot of Mortality grouped by neutrophil to lymphocyte ratio (NLR).

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