Ferritin level: A predictor of severity and mortality in hospitalized COVID-19 patients

Moudhi Alroomi 1, Rajesh Rajan 2, Abdulaziz A Omar 3, Ahmad Alsaber 4, Jiazhu Pan 4, Mina Fatemi 5, Kobalava D Zhanna 6, Wael Aboelhassan 7, Farah Almutairi 8, Naser Alotaibi 9, Mohammad A Saleh 8, Noor AlNasrallah 9, Bader Al-Bader 8, Haya Malhas 10, Maryam Ramadhan 11, Mohammed Abdullah 1, Hassan Abdelnaby 12 13

Affiliations

12 January 2021

-

doi: 10.1002/iid3.517

Abstract

Introduction: This study aims to investigate in-hоsрitаl mоrtаlity in severe асute resрirаtоry syndrоme соrоnаvirus 2 раtients strаtified by serum ferritin levels.

Methods: Patients were stratified based on ferritin levels (ferritin levels ≤ 1000 or >1000).

Results: Approximately 89% (118) of the patients with ferritin levels > 1000 had pneumonia, and 51% (67) had hypertension. Fever (97, 73.5%) and shortness of breath (80, 61%) were two major symptoms among the patients in this group. Logistic regression analysis indicated that ferritin level (odds ratio [OR] = 0.36, 95% confidence interval [CI] = 0.21-0.62; p < .001), male sex (OR = 2.63, 95% CI = 1.43-5.06; p = .003), hypertension (OR = 4.16, 95% CI = 2.42-7.36; p < .001) and pneumonia (OR = 8.48, 95% CI = 3.02-35.45; p < .001) had significance in predicting in-hospital mortality. Additionally, the Cox proportional hazards analysis and Kaplan-Meier survival probability plot showed a higher mortality rate among patients with ferritin levels > 1000.

Conclusion: In this study, higher levels of serum ferritin were found to be an independent predictor of in-hоsрitаl mоrtаlity.

Keywords: COVID-19; SARS-CoV-2; ferritin; hypertension; in-hospital mortality; male sex; pneumonia.

Conflict of interest statement

The authors declare that there are no conflict of interests.

Figures

Figure 1 Kaplan–Meier survival plot of mortality grouped by fertility

Figure 1 Kaplan–Meier survival plot of mortality grouped by fertility

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