Veno-occlusive disease/sinusoidal obstruction syndrome after haematopoietic stem cell transplantation: Middle East/North Africa regional consensus on prevention, diagnosis and management

A H Al Jefri 1, H Abujazar 2, A Al-Ahmari 1 3, A Al Rawas 4, Z Al Zahrani 5, A Alhejazi 6, M A Bekadja 7, A Ibrahim 8, M Lahoucine 9, S Ousia 10, A Bazarbachi 11

Affiliations

01 April 2017

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doi: 10.1038/bmt.2016.300

Abstract

Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) of the liver is a serious, early complication of haematopoietic stem cell transplantation (HSCT), severe and very severe forms of which are associated with a high mortality rate. A wide variety of patient, disease and treatment-related risk factors for VOD/SOS have been identified. Several bodies have published recommendations for the diagnosis, prevention and management of VOD/SOS following HSCT. A group of regional experts have developed a consensus statement on the diagnosis, prevention and management of VOD/SOS in the Middle East and North Africa region to help in the management of HSCT patients in the region. Risk factors of particular relevance in the region include iron overload in thalassaemia patients, some hereditary metabolic disorders due to consanguinity and infection with hepatitis virus B or C. Recommendations include diagnosis of VOD/SOS based on established clinical criteria, prophylaxis with defibrotide and/or ursodeoxycholic acid in patients at increased risk of VOD/SOS, and treatment with defibrotide for patients with severe/very severe VOD/SOS (and, if clinically indicated, in those with moderate or rapidly progressing VOD/SOS, as per the new European Society for Blood and Marrow Transplantation classification).

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References

  1.  
    1. Biol Blood Marrow Transplant. 2011 Nov;17(11):1713-20 - PubMed
  2.  
    1. Br J Haematol. 2013 Nov;163(4):444-57 - PubMed
  3.  
    1. Bone Marrow Transplant. 1992 Sep;10(3):197-214 - PubMed
  4.  
    1. Cochrane Database Syst Rev. 2015 May 27;(5):CD009311 - PubMed
  5.  
    1. Biol Blood Marrow Transplant. 2004 May;10(5):347-54 - PubMed
  6.  
    1. Bone Marrow Transplant. 2016 Jul;51(7):906-12 - PubMed
  7.  
    1. Blood. 2002 Dec 15;100(13):4337-43 - PubMed
  8.  
    1. Lancet. 2012 Apr 7;379(9823):1301-9 - PubMed
  9.  
    1. Bone Marrow Transplant. 2007 Jul;40(1):79-82 - PubMed
  10.  
    1. Bone Marrow Transplant. 2015 Jun;50(6):781-9 - PubMed
  11.  
    1. Biol Blood Marrow Transplant. 2013 Mar;19(3):500-3 - PubMed
  12.  
    1. Biol Blood Marrow Transplant. 2010 Feb;16(2):157-68 - PubMed
  13.  
    1. Blood. 2016 Mar 31;127(13):1656-65 - PubMed
  14.  
    1. Transplantation. 1987 Dec;44(6):778-83 - PubMed
  15.  
    1. World J Gastroenterol. 2012 Apr 28;18(16):1851-60 - PubMed
  16.  
    1. Biol Blood Marrow Transplant. 2010 Jul;16(7):1005-17 - PubMed
  17.  
    1. Biol Blood Marrow Transplant. 2016 Mar;22(3):400-9 - PubMed
  18.  
    1. World J Transplant. 2012 Apr 24;2(2):27-34 - PubMed
  19.  
    1. Blood. 1998 Aug 1;92(3):737-44 - PubMed
  20.  
    1. Bone Marrow Transplant. 2008 Feb;41(3):287-91 - PubMed

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