The Allergic Rhinitis and Its Impact on Asthma (ARIA) Approach of Value-Added Medicines: As-Needed Treatment in Allergic Rhinitis
Jean Bousquet 1, Mondher Toumi 2, Bernardo Sousa-Pinto 3, Josep M Anto 4, Anna Bedbrook 5, Wienczyslawa Czarlewski 6, Arunas Valiulis 7, Ignacio J Ansotegui 8, Sinthia Bosnic-Anticevich 9, Luisa Brussino 10, G Walter Canonica 11, Lorenzo Cecchi 12, Ivan Cherrez-Ojeda 13, Tomas Chivato 14, Elísio M Costa 15, Alvaro A Cruz 16, Stefano Del Giacco 17, Joao A Fonseca 3, Bilun Gemicioglu 18, Tari Haahtela 19, Juan Carlos Ivancevich 20, Marek Jutel 21, Igor Kaidashev 22, Ludger Klimek 23, Violeta Kvedariene 24, Piotr Kuna 25, Désirée E Larenas-Linnemann 26, Brian Lipworth 27, Mario Morais-Almeida 28, Joaquim Mullol 29, Nikolaos G Papadopoulos 30, Vincenzo Patella 31, Nhân Pham-Thi 32, Frederico S Regateiro 33, Philip W Rouadi 34, Boleslaw Samolinski 35, Aziz Sheikh 36, Luis Taborda-Barata 37, Maria Teresa Ventura 38, Arzu Yorgancioglu 39, Mihaela Zidarn 40, Torsten Zuberbier 41
Affiliations
Affiliations
- Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; University Hospital Montpellier, Montpellier, France; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany. Electronic address: jean.bousquet@orange.fr.
- Public Health, Aix-Marseille University, Marseille, France.
- MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; CINTESIS-Center for Health Technology and Services Research, University of Porto, Porto, Portugal; RISE-Health Research Network, University of Porto, Porto, Portugal.
- ISGlobaL, Barcelona Institute for Global Health, Barcelona, Spain; Hospital del Mar Medical Research Institute, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; CIBER Epidemiología y Salud Pública, Barcelona, Spain.
- ARIA, Montpellier, France.
- Medical Consulting Czarlewski, Levallois, France.
- Institute of Clinical Medicine and Institute of Health Sciences, Medical Faculty of Vilnius University, Vilnius, Lithuania.
- Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain.
- Quality Use of Respiratory Medicine Group, Woolcock Institute of Medical Research, University of Sydney, and Sydney Local Health District, Sydney, New South Wales, Australia.
- Department of Medical Sciences, Allergy and Clinical Immunology Unit, University of Torino and Mauriziano Hospital, Torino, Italy.
- Department of Biomedical Sciences, Humanitas University, Pieve Emanuele and Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy.
- SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy.
- Department of Allergy and Pulmonology, Espiritu Santo University, Samborondón, Ecuador.
- School of Medicine, University CEU San Pablo, Madrid, Spain.
- UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto (Porto4Ageing), Porto, Portugal.
- Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Bahia, Brazil.
- Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula," University of Cagliari, Cagliari, Italy.
- Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
- Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
- Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina.
- Department of Clinical Immunology, Wrocław Medical University, Wroclaw, Poland; ALL-MED Medical Research Institute, Wroclaw, Poland.
- Poltava State Medical University, Poltava Oblast, Ukraine.
- Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany; Center for Rhinology and Allergology, Wiesbaden, Germany.
- Institute of Biomedical Sciences, Department of Pathology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
- Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.
- Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, México.
- Scottish Centre for Respiratory Research, Cardiovascular and Diabetes Medicine, Medical Research Institute, Ninewells Hospital, University of Dundee, Dundee, United Kingdom.
- Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.
- Rhinology Unit and Smell Clinic, ENT Department, Hospital Clinic, Clinical and Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain.
- Allergy Department, Second Pediatric Clinic, University of Athens, Athens, Greece.
- Division of Allergy and Clinical Immunology, Department of Medicine, Agency of Health ASL Salerno, "Santa Maria della Speranza" Hospital, Battipaglia, Salerno, Italy.
- Ecole Polytechnique Palaiseau, Institut de Recherche Bio-Médicale des Armées, Bretigny, France.
- Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Institute of Immunology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal; ICBR - Coimbra Institute for Clinical and Biomedical Research, CIBB, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
- Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon; ENT Department, Dar Al Shifa Hospital, Salmiya, Kuwait.
- Department of Prevention of Environmental Hazards, Allergology, and Immunology, Medical University of Warsaw, Warsaw, Poland.
- Usher Institute, The University of Edinburgh, Edinburgh, United Kingdom.
- UBIAir-Clinical and Experimental Lung Centre, University of Beira Interior, Covilhã, Portugal; CICS-Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal; Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal.
- Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy.
- Department of Pulmonology, Celal Bayar University, Manisa, Turkey.
- University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
- Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.
Abstract
Drug repurposing is a major field of value-added medicine. It involves investigating and evaluating existing drugs for new therapeutic purposes that address unmet healthcare needs. Several unmet needs in allergic rhinitis could be improved by drug repurposing. This could be game-changing for disease management. Current medications for allergic rhinitis are centered on continuous long-term treatment, and medication registration is based on randomized controlled trials carried out for a minimum of 14 days with adherence of 70% or greater. A new way of treating allergic rhinitis is to propose as-needed treatment depending on symptoms, rather than classical continuous treatment. This rostrum will discuss existing clinical trials on as-needed treatment for allergic rhinitis and real-world data obtained by the mobile health app MASK-air, which focuses on digitally-enabled, patient-centered care pathways.
Keywords: Allergic rhinitis; MASK-air; Repurposing; Treatment; Value-added medicine.
References
https://pubmed.ncbi.nlm.nih.gov/