Can 68Ga-DOTA Peptides Be Potential Radiotracers for PET Imaging of the Spleen?
Affiliations
Affiliations
- Department of Nuclear Medicine, Kuwait University Faculty of Medicine, Safat, Kuwait isarikaya99@yahoo.com.
- Department of Nuclear Medicine, Kuwait University Faculty of Medicine, Safat, Kuwait.
- Department of Nuclear Medicine, Trakya University Faculty of Medicine, Edirne, Turkey and.
- Department of Nuclear Medicine, Mubarak Al-Kabeer Hospital, Jabriya, Kuwait.
Abstract
On radionuclide somatostatin receptor imaging studies, the spleen shows high physiologic uptake. Reducing the intensity of the image settings helps to better assess the distribution of radiotracer in the spleen. In our routine studies, we incidentally recognized that 68Ga-DOTANOC PET provides higher-resolution splenic images than 111In-octreotide SPECT. Autoradiography and immunohistochemistry studies have shown that somatostatin receptors are located mainly in the red pulp of the spleen. The distribution of 68Ga-DOTANOC in the spleen appears to correlate with the distribution of red pulp. In this article, we present 68Ga-DOTANOC PET/CT spleen images of our patients.
Keywords: 68Ga-DOTANOC; PET/CT; red pulp; somatostatin receptor; spleen.
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