68Ga-PMSA Uptake in the Lung: Metastatic Versus Primary Lung Tumor

Sharjeel Usmani, Alya'a Sadeq 1, Fahad Marafi 2, Abdulredha Esmail 2, Fareeda Al Kandari 1, Najeeb Ahmed 2

Affiliations

01 February 2020

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doi: 10.1097/RLU.0000000000002870

Abstract

Ga-PSMA is a promising tracer for both primary staging and detection of biochemical recurrence in prostate cancer. PSMA is also expressed in the neovascular endothelium of various solid malignancies possibly due to tumor-associated angiogenic factors and endothelial cell sprouting. We report a case of a 73-year-old man of prostate cancer with rising prostate-specific antigen levels. Ga-PSMA PET/CT was performed, which showed a focal lung lesion, with subsequent histological confirmation of adenocarcinoma of the lung. Incidental lung lesions on Ga-PSMA in prostate cancer patients should elicit a differential of primary lung malignancy, especially if clinical and morphological suspicion is high.

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