Management of Type 2 diabetes in Ramadan: Low-ratio premix insulin working group practical advice

Affiliations


Abstract

The challenge of insulin use during Ramadan could be minimized, if people with diabetes are metabolically stable and are provided with structured education for at least 2-3 months pre-Ramadan. Although, American diabetes association (ADA) recommendations 2010 and South Asian Consensus Guideline 2012 deal with management of diabetes in Ramadan and changes in insulin dosage, no specific guidance on widely prescribed low-ratio premix insulin is currently available. Hence, the working group for insulin therapy in Ramadan, after collective analysis, evaluation, and opinion from clinical practice, have formulated a practical advice to empower physicians with pre-Ramadan preparation, dose adjustment, and treatment algorithm for self-titration of low-ratio premix insulin.

Keywords: Hyperglycemia; hypoglycemia; low-ratio premix insulin; ramadan; type 2 diabetes.

Conflict of interest statement

Conflict of Interest: None declared.


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References

  1.  
    1. Benaji B, Mounib N, Roky R, Aadil N, Houti IE, Moussamih S, et al. Diabetes and Ramadan review of the literature. Diabetes Res Clin Pract. 2006;73:117–25. - PubMed
  2.  
    1. Jaleel MA, Raza SA, Fathima FN, Jaleel BN. Ramadan and diabetes: As-Saum (The fasting) Indian J Endocrinol Metab. 2011;15:268–73. - PMC - PubMed
  3.  
    1. Salti I, Bénard E, Detournay B, Bianchi-Biscay M, Brigand CL, Voinet C, et al. A population-based study of diabetes and its characteristics during the fasting month of ramadan in 13 countries: Results of the epidemiology of diabetes and ramadan 1422/2001 (EPIDIAR) study. Diabetes Care. 2004;27:2306–11. - PubMed
  4.  
    1. Elmehdawi RR, Mukhtad NA, Allaghi NI, Elmajberi SJ. Fasting of Ramadan in peoples with diabetes in Benghazi, Libya: An exploratory study. Libyan J Med. 2010:5. - PMC - PubMed
  5.  
    1. Al-Arouj M, Assaad-Khalil S, Buse J, Fahdil I, Fahmy M, Hafez S, et al. Recommendations for management of diabetes during Ramadan: Update 2010. Diabetes Care. 2010;33:1895–902. - PMC - PubMed
  6.  
    1. Ahmad J, Pathan MF, Jaleel MA, Fathima FN, Raza SA, Khan AK, et al. Diabetic emergencies including hypo during Ramadan. Indian J Endocrinol Metab. 2012;16:512–5. - PMC - PubMed
  7.  
    1. Bravis V, Hui E, Salih S, Mehar S, Hassanein M, Devendra D. Ramadan education and awareness in diabetes (READ) programme for muslims with type 2 diabetes who fast during Ramadan. Diabet Med. 2010;27:327–31. - PubMed
  8.  
    1. Hassanein MM. Diabetes and ramadan: How to achieve a safer fast for Muslims with diabetes. Br J Diabetes Vasc Dis. 2010;10:246–50.
  9.  
    1. Indian National Consensus Group. Premix Insulin: Initiation and continuation guidelines for management of diabetes in primary care. J Assoc Physician India. 2009;57:S42–6.
  10.  
    1. Soewondo P, Adam JM, Sanusi H, Soeatmadji DW. A multicenter, prospective, non-interventional evaluation of efficacy and safety of using biphasic insulin aspart as monotherapy, or in combination with oral hypoglycaemic agent, in the treatment of type 2 Diabetic Patients Before, During, and After Ramadan. J Indones Med Assoc. 2009;59:574–9.
  11.  
    1. Mattoo V, Milicevic Z, Malone JK, Schwarzenhofer M, Ekangaki A, Levitt LK, et al. A comparison of insulin lispro Mix 25 and human insulin 30/70 in the treatment of type 2 diabetes during Ramadan. Diabetes Res Clin Pract. 2003;59:137–43. - PubMed
  12.  
    1. Hui E, Bravis V, Salih S, Hassanein M, Devendra D. Comparison of Humalog Mix 50 with Human insulin Mix 30 in type 2 diabetes patients during Ramadan. Int J Clin Pract. 2010;64:1095–99. - PubMed