Joint statement for the diagnosis, management, and prevention of chronic obstructive pulmonary disease for Gulf Cooperation Council countries and Middle East-North Africa region, 2017
Affiliations
Affiliations
- College of Medicine, University of Sharjah, Sharjah.
- Department of Pulmonary Medicine, Rashid Hospital, Dubai Health Authority, Dubai.
- Department of Pulmonary Medicine, Zayed Military Hospital, Abu Dhabi, United Arab Emirates.
- Chest Department, Ain Shams University, Cairo, Egypt.
- Department of Pulmonology and Allergy, Al-Sabah Hospital, Kuwait City, Kuwait.
- Department of Pneumology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
- Centre for Respiratory Medicine and Allergy, University of Manchester, University Hospital of South Manchester, Manchester, UK.
- Pulmonary and Critical Care, Istishari Hospital, Amman, Jordan.
- Faculty of Medicine.
- Hariri School of Nursing, American University of Beirut, Beirut, Lebanon.
Abstract
Smoking and subsequent development of COPD is an ever-increasing epidemic in Arabian Gulf and Middle East countries, with no signs of decline. The important fact to be highlighted is that this COPD epidemic of increasing incidence and prevalence is mostly unrecognized by patients, due to the common attribution of symptoms to "smoker's cough", and the underdiagnosis and undertreatment by physicians because the common signs and symptoms masquerade as asthma. Consequently, there are long-term adverse effects of missing the diagnosis. The purpose of this review article is to focus upon the status of COPD in Arabian Gulf and Middle East countries, stressing the increasing burden of smoking and COPD, to emphasize the specific factors leading to rise in prevalence of COPD, to bring to light the underdiagnosis and undermanagement of COPD, and to treat COPD in conformity with standard guidelines with local and regional modifications. This review ends with suggestions and recommendations to the health department to formulate policies and to generate awareness among the general public about the side effects of smoking and consequences of COPD.
Keywords: COPD; Gulf Cooperation Council countries; Middle East; bakhour; medwakh; prevalence of smoking; shisha; water pipe.
Conflict of interest statement
Disclosure The authors report no conflicts of interest in this work
Similar articles
Al-Moamary MS, Köktūrk N, Idrees MM, Şen E, Juvelekian G, Saleh WA, Zoumot Z, Behbehani N, Hatem A, Masoud HH, Snouber A, van Zyl-Smit RN.Respir Med. 2021 Nov-Dec;189:106641. doi: 10.1016/j.rmed.2021.106641. Epub 2021 Oct 5.PMID: 34649155 Review.
Rossi A, Butorac-Petanjek B, Chilosi M, Cosío BG, Flezar M, Koulouris N, Marin J, Miculinic N, Polese G, Samaržija M, Skrgat S, Vassilakopoulos T, Vukić-Dugac A, Zakynthinos S, Miravitlles M.Int J Chron Obstruct Pulmon Dis. 2017 Aug 29;12:2593-2610. doi: 10.2147/COPD.S132236. eCollection 2017.PMID: 28919728 Free PMC article. Review.
Smoking duration, respiratory symptoms, and COPD in adults aged ≥45 years with a smoking history.
Liu Y, Pleasants RA, Croft JB, Wheaton AG, Heidari K, Malarcher AM, Ohar JA, Kraft M, Mannino DM, Strange C.Int J Chron Obstruct Pulmon Dis. 2015 Jul 21;10:1409-16. doi: 10.2147/COPD.S82259. eCollection 2015.PMID: 26229460 Free PMC article.
Menezes AM, Landis SH, Han MK, Muellerova H, Aisanov Z, van der Molen T, Oh YM, Ichinose M, Mannino DM, Davis KJ.Int J Chron Obstruct Pulmon Dis. 2015 Jan 20;10:159-72. doi: 10.2147/COPD.S74315. eCollection 2015.PMID: 25653515 Free PMC article.
Mohammad Y, Shaaban R, Al-Zahab BA, Khaltaev N, Bousquet J, Dubaybo B.Int J Chron Obstruct Pulmon Dis. 2013;8:473-82. doi: 10.2147/COPD.S50551. Epub 2013 Oct 2.PMID: 24124359 Free PMC article.
Cited by
Update on Asthma-COPD Overlap (ACO): A Narrative Review.
Mekov E, Nuñez A, Sin DD, Ichinose M, Rhee CK, Maselli DJ, Coté A, Suppli Ulrik C, Maltais F, Anzueto A, Miravitlles M.Int J Chron Obstruct Pulmon Dis. 2021 Jun 17;16:1783-1799. doi: 10.2147/COPD.S312560. eCollection 2021.PMID: 34168440 Free PMC article. Review.
Gaps in COPD Guidelines of Low- and Middle-Income Countries: A Systematic Scoping Review.
Tabyshova A, Hurst JR, Soriano JB, Checkley W, Wan-Chun Huang E, Trofor AC, Flores-Flores O, Alupo P, Gianella G, Ferdous T, Meharg D, Alison J, Correia de Sousa J, Postma MJ, Chavannes NH, van Boven JFM.Chest. 2021 Feb;159(2):575-584. doi: 10.1016/j.chest.2020.09.260. Epub 2020 Oct 8.PMID: 33038390 Free PMC article.
Noibi S, Mohy A, Gouhar R, Shaker F, Lukic T, Al-Jahdali H.BMC Public Health. 2020 Aug 8;20(1):1211. doi: 10.1186/s12889-020-09259-3.PMID: 32770967 Free PMC article. Review.
Wu JJ, Xu HR, Zhang YX, Li YX, Yu HY, Jiang LD, Wang CX, Han M.Medicine (Baltimore). 2019 Nov;98(46):e17996. doi: 10.1097/MD.0000000000017996.PMID: 31725666 Free PMC article.
Aberrant MicroRNAomics in Pulmonary Complications: Implications in Lung Health and Diseases.
Dutta RK, Chinnapaiyan S, Unwalla H.Mol Ther Nucleic Acids. 2019 Dec 6;18:413-431. doi: 10.1016/j.omtn.2019.09.007. Epub 2019 Sep 18.PMID: 31655261 Free PMC article. Review.
References
-
- Global Initiative for Chronic Obstructive Lung Disease Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease. 2017. [Accessed January 12, 2017]. Available from: http://goldcopd.org/gold-2017-global-strategy-diagnosis-management-preve.... - PubMed
-
- Murray CJ, Lopez AD, Mathers CD, Stein C. The Global Burden of Disease 2000 project: aims, methods and data sources. 2001. [Accessed January 22, 2017]. Available from: http://www.who.int/healthinfo/paper36.pdf.
-
- World Health Organization . The Global Burden of Disease: 2004 Update. Geneva: WHO; 2008.
-
- World Health Organization . Risk factors for chronic respiratory diseases. In: Bousquet J, Khaltaev N, editors. Global Surveillance, Prevention and Control of Chronic Respiratory Diseases: A Comprehensive Approach. Geneva: WHO; 2007. pp. 37–55.
-
- Khattab A, Javaid A, Iraqi G, et al. Smoking habits in the Middle East and North Africa: results of the BREATHE study. Respir Med. 2012;106(Suppl 2):S16–S24. - PubMed
-
- Riachy M, Rehayem C, Khoury C, et al. Are narghile smokers different from cigarette smokers? Rev Mal Respir. 2008;25:313–318. French. - PubMed
-
- Maziak W, Eissenberg T, Ward KD. Patterns of waterpipe use and dependence: implications for intervention development. Pharmacol Biochem Behav. 2005;80:173–179. - PubMed
-
- Lindberg A, Eriksson B, Larsson LG, Rönmark E, Sandström T, Lundbäck B. Seven-year cumulative incidence of COPD in an age-stratified general population sample. Chest. 2006;129:879–885. - PubMed
-
- Polatli M, Kheder AB, Wali S, et al. Chronic obstructive pulmonary disease and associated healthcare resource consumption in the Middle East and North Africa: the BREATHE study. Respir Med. 2012;106(Suppl 2):S75–S85. - PubMed
-
- Yin P, Jiang CQ, Cheng KK, et al. Passive smoking exposure and risk of COPD among adults in China: the Guangzhou Biobank Cohort study. Lancet. 2007;370:751–757. - PubMed
-
- Hu G, Zhou Y, Tian J, et al. Risk of COPD from exposure to biomass smoke: a metaanalysis. Chest. 2010;138:20–31. - PubMed
-
- Cohen R, Sexton KG, Yeatts KB. Hazard assessment of United Arab Emirates (UAE) incense smoke. Sci Total Environ. 2013;458–460:176–186. - PubMed
-
- El Hasnaoui A, Rashid N, Lahlou A, Salhi H, Doble A, Nejjari C. Chronic obstructive pulmonary disease in the adult population within the Middle East and North Africa region: rationale and design of the BREATHE study. Respir Med. 2012;106(Suppl 2):S3–S15. - PubMed
-
- World Health Organization Chronic obstructive pulmonary disease (COPD) 2016. [Accessed January 15,2017]. Available from: www.who.int/mediacentre/factsheets/fs315/en.
-
- Tageldin MA, Nafti S, Khan JA, et al. Distribution of COPD-related symptoms in the Middle East and North Africa: results of the BREATHE study. Respir Med. 2012;106(Suppl 2):S25–S32. - PubMed
-
- Al Zaabi A, Asad F, Abdou J, et al. Prevalence of COPD in Abu Dhabi, United Arab Emirates. Respir Med. 2011;105:566–570. - PubMed
-
- Al Ghobain M, Alhamad EH, Alorainy HS, Al Kassimi F, Lababidi H, Al-Hajjaj MS. The prevalence of chronic obstructive pulmonary disease in Riyadh, Saudi Arabia: a BOLD study. Int J Tuberc Lung Dis. 2015;9:1252–1257. - PubMed
-
- Said AF, Ewis AA, Omran AA, Magdy ME, Saleeb MF. Prevalence and predictors of chronic obstructive pulmonary disease among high-risk Egyptians. Egypt J Bronchol. 2015;9:27–33.
-
- Badway MS, Hamed AF, Yousef FM. Prevalence of chronic obstructive pulmonary disease (COPD) in Qena Governorate. Egypt J Chest Dis Tuberc. 2016;65:29–34.
-
- El Rhazi K, Nejjari C, BenJelloun MC, El Biaze M, Attassi M, Garcia-Larsen V. Prevalence of chronic obstructive pulmonary disease in Fez, Morocco: results from the BOLD study. Int J Tuberc Lung Dis. 2016;20:136–141. - PubMed
-
- World Health Organization Prevalence of tobacco smoking. [Accessed January 15, 2017]. Available from: http://www.who.int/gho/tobacco/use/en.
-
- Menezes AM, Perez-Padilla R, Jardim JR, et al. Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): a prevalence study. Lancet. 2005;366:1875–1881. - PubMed
-
- Kart L, Akkoyunlu ME, Bayram M, et al. COPD: an underdiagnosed disease at hospital environment. Wien Klin Wochenschr. 2014;126:73–78. - PubMed
-
- Eisner MD, Anthonisen N, Coultas D, et al. An official American Thoracic Society public policy statement: novel risk factors and the global burden of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010;182:693–718. - PubMed
-
- Ezzati M, Lopez AD. Estimates of global mortality attributable to smoking in 2000. Lancet. 2003;362:847–852. - PubMed
-
- Khattab A, Javaid A, Iraqi G, et al. Smoking habits in the Middle East and North Africa: results of the BREATHE study. Respir Med. 2012;106(Suppl 2):S16–S24. - PubMed
-
- Al Zaabi A, Mahboub BH, Vats MG, Iqbal MN, Vats DM. Chronic obstructive pulmonary disease in Middle East and UAE: an unrecognized underestimated epidemic. J Lung Pulm Respir Res. 2016;3:00089.
-
- Akl EA, Gaddam S, Gunukula SK, Honeine R, Jaoude PA, Irani J. The effects of water pipe tobacco smoking on health outcomes: a systematic review. Int J Epidemiol. 2010;39:834–857. - PubMed
-
- She J, Yang P, Wang Y, et al. Chinese water-pipe smoking and the risk of COPD. Chest. 2014;146:924–931. - PubMed
-
- Salameh P, Waked M, Khoury F, et al. Waterpipe smoking and dependence are associated with chronic bronchitis: a case-control study in Lebanon. East Mediterr Health J. 2012;18:996–1004. - PubMed
-
- Salameh P, Salame J, Khayat G, et al. Exposure to outdoor air pollution and chronic bronchitis in adults: a case-control study. Int J Occup Environ Med. 2012;3:165–177. - PubMed
-
- Gauderman WJ, Avol E, Gilliland F, et al. The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med. 2004;351:1057–1067. - PubMed
-
- Gauderman WJ, Vora H, McConnell R, et al. Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study. Lancet. 2007;369:571–577. - PubMed
-
- Rojas-Martinez R, Perez-Padilla R, Olaiz-Fernandez G, et al. Lung function growth in children with long-term exposure to air pollutants in Mexico City. Am J Respir Crit Care Med. 2007;176:377–384. - PubMed
-
- Downs SH, Schindler C, Liu LJ, et al. Reduced exposure to PM10 and attenuated age-related decline in lung function. N Engl J Med. 2007;357:2338–2347. - PubMed
-
- Euler G, Abbey D, Magie A, Hodgkin J. Chronic obstructive pulmonary disease symptom effects of long-term cumulative exposure to ambient levels of total suspended particulates and sulfur dioxide in California Seventh-Day Adventist residents. Arch Environ Health. 1987;42:213–222. - PubMed
-
- Abbey D, Burchette R, Knutsen S, McDonnel W, Lebowitz M, Enright P. Long-term particulate and other pollutants and lung function in nonsmokers. Am J Respir Crit Care Med. 1998;158:289–298. - PubMed
-
- Andersen ZJ, Hvidberg M, Jensen SS, et al. COPD and long-term exposure to traffic-related air pollution: a cohort study. Am J Respir Crit Care Med. 2011;183:455–461. - PubMed
-
- Smith KR. Biofuels, Air Pollution, and Health. New York: Plenum Press; 1987.
-
- Pandey M, Basnyat B, Neupane R. Chronic bronchitis and cor pulmonale in Nepal. Lung India. 1988;6:209–210.
-
- Behera D. An analysis of effect of common domestic fuels on respiratory function. Indian J Chest Dis Allied Sci. 1997;39:235–243. - PubMed
-
- Behera D, Jindal SK. Respiratory symptoms in Indian women using domestic cooking fuels. Chest. 1991;100:385–388. - PubMed
-
- Behera D, Jindal SK, Malhotra HS. Ventilatory function in nonsmoking rural Indian women using different cooking fuels. Respiration. 1994;61:89–92. - PubMed
-
- Cetinkaya F, Gülmez I, Aydin T, Oztürk Y, Ozesmi M, Demir R. Prevalence of chronic bronchitis and associated risk factors in a rural area of Kayseri, central Anatolia, Turkey. Monaldi Arch Chest Dis. 2000;55:189–193. - PubMed
-
- Dossing M, Khan J, al-Rabiah F. Risk factors for chronic obstructive lung disease in Saudi Arabia. Respir Med. 1994;88:519–522. - PubMed
-
- Ekici A, Ekici M, Kurtipek E, et al. Obstructive airway diseases in women exposed to biomass smoke. Environ Res. 2005;99:93–98. - PubMed
-
- Kiraz K, Kart L, Demir R, et al. Chronic pulmonary disease in rural women exposed to biomass fumes. Clin Invest Med. 2003;26:243–248. - PubMed
-
- Pérez-Padilla R, Regalado J, Vedal S, et al. Exposure to biomass smoke and chronic airway disease in Mexican women: a case-control study. Am J Respir Crit Care Med. 1996;154:701–706. - PubMed
-
- Regalado J, Pérez-Padilla R, Sansores R, et al. The effect of biomass burning on respiratory symptoms and lung function in rural Mexican women. Am J Respir Crit Care Med. 2006;174:901–905. - PubMed
-
- Shrestha IL, Shrestha SL. Indoor air pollution from biomass fuels and respiratory health of the exposed population in Nepalese households. Int J Occup Environ Health. 2005;11:150–160. - PubMed
-
- Dutt D, Srinivasa DK, Rotti SB, Sahai A, Konar D. Effect of indoor air pollution on the respiratory system of women using different fuels for cooking in an urban slum of Pondicherry. Natl Med J India. 1996;9:113–117. - PubMed
-
- Dennis RJ, Maldonado D, Norman S, Baena E, Martinez G. Woodsmoke exposure and risk for obstructive airways disease among women. Chest. 1996;109:115–119. - PubMed
-
- Orozco-Levi M, Garcia-Aymerich J, Villar J, Ramirez-Sarmiento A, Anto JM, Gea J. Wood smoke exposure and risk of chronic obstructive pulmonary disease. Eur Respir J. 2006;27:542–546. - PubMed
-
- Caballero A, Torres-Duque CA, Jaramillo C, et al. Prevalence of COPD in five Colombian cities situated at low, medium, and high altitude (PREPOCOL study) Chest. 2008;133:343–349. - PubMed
-
- Ulrik CS, Backer V. Nonreversible airflow obstruction in life-long nonsmokers with moderate to severe asthma. Eur Respir J. 1999;14:892–896. - PubMed
-
- Cassino C, Berger KI, Goldring RM, et al. Duration of asthma and physiologic outcomes in elderly nonsmokers. Am J Respir Crit Care Med. 2000;162:1423–1428. - PubMed
-
- Beaglehole R, Bonita R, Alleyne G, et al. UN High-Level Meeting on Non-Communicable Diseases: addressing four questions. Lancet. 2011;378:449–455. - PubMed
-
- European COPD Coalition Prevalence in EU. [Accessed January 14, 2017]. Available from: http://www.copdcoalition.eu/about-copd/prevalence.
-
- Chapman KR, Mannino DM, Soriano JB, et al. Epidemiology and costs of chronic obstructive pulmonary disease. Eur Respir J. 2006;27:188–207. - PubMed
-
- Centers for Disease Control and Prevention Chronic obstructive pulmonary disease among adults: United States, 2011. MMWR Morb Mortal Wkly Rep. 2012;61:938–943. - PubMed
-
- Foster TS, Miller JD, Marton JP, Caloyeras JP, Russell MW, Menzin J. Assessment of the economic burden of COPD in the U.S.: a review and synthesis of the literature. COPD. 2006;3:211–218. - PubMed
-
- Mehrotra A, Oluwole AM, Gordon SB. The burden of COPD in Africa: a literature review and prospective survey of the availability of spirometry for COPD diagnosis in Africa. Trop Med Int Health. 2009;14:840–848. - PubMed
-
- Shaya FT, El Khoury AC, Samant ND, Scharf SM. Utilization of health care resources in a high-risk Medicaid population with chronic obstructive pulmonary disease. Phys Ther. 2006;31:261–268.
-
- Menzin J, Boulanger L, Marton J, et al. The economic burden of chronic obstructive pulmonary disease (COPD) in a U.S. Medicare population. Respir Med. 2008;102:124856. - PubMed
-
- Chung F, Barnes N, Allen M, et al. Assessing the burden of respiratory disease in the UK. Respir Med. 2002;96:963–975. - PubMed
-
- Mannino DM, Bradman S. The epidemiology and economics of chronic pulmonary obstructive disease. Proc Am Thorac Soc. 2007;4:502–506. - PubMed
-
- Wouters EF. The burden of COPD in the Netherlands: results from the Confronting COPD survey. Respir Med. 2003;97(Suppl C):S51–S59. - PubMed
-
- Wouters EF. Economic analysis of the Confronting COPD survey: an overview of results. Respir Med. 2003;97(Suppl C):S3–S14. - PubMed
-
- Dalal AA, Shah M, Lunacsek O, Hanania NA. Clinical and economic burden of patients diagnosed with COPD with comorbid cardiovascular disease. Respir Res. 2011;105:1516–1522. - PubMed
-
- Alzaabi A, Mahboub B, Salhi H, Kajingu W, Rashid N, El-Hasnaoui A. Waterpipe use in the Middle East and North Africa: data from the Breathe study. Nicotine Tob Res. 2016 Oct 10; Epub. - PubMed
-
- Kessler R, Partridge MR, Miravitlles M, et al. Symptom variability in patients with severe COPD: a pan-European cross-sectional study. Eur Respir J. 2011;37:264–272. - PubMed
-
- de los Monteros MJ, Peña C, Hurtado EJ, Jareño J, Miravitlles M. Variability of respiratory symptoms in severe COPD. Arch Bronconeumol. 2012;48:3–7. - PubMed
-
- Zwar NA, Marks GB, Hermiz O, et al. Predictors of accuracy of diagnosis of chronic obstructive pulmonary disease in general practice. Med J Aust. 2011;195:168–171. - PubMed
-
- Simon PM, Schwartzstein RM, Weiss JW, Fencl V, Teght-soonian M, Weinberger SE. Distinguishable types of dyspnea in patients with shortness of breath. Am Rev Respir Dis. 1990;142:1009–1014. - PubMed
-
- Burrows B, Niden AH, Barclay WR, et al. Chronic obstructive lung disease – II: relationship of clinical and physiologic findings to the severity of airways obstruction. Am Rev Respir Dis. 1965;91:665–678. - PubMed
-
- Definition and classification of chronic bronchitis for clinical and epidemiological purposes. Lancet. 1965;1:775–779. No authors listed. - PubMed
-
- Schols AM, Soeters PB, Dingemans AM, Mostert R, Frantzen PJ, Wouters EF. Prevalence and characteristics of nutritional depletion in patients with stable COPD eligible for pulmonary rehabilitation. Am Rev Respir Dis. 1993;147:1151–1156. - PubMed
-
- Schols AM, Slangen J, Volovics L, Wouters EF. Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157:1791–1797. - PubMed
-
- Holguin F, Folch E, Redd SC, Mannino DM. Comorbidity and mortality in COPD-related hospitalizations in the United States, 1979 to 2001. Chest. 2005;128:2005–2011. - PubMed
-
- Kesten S, Chapman KR. Physician perceptions and management of COPD. Chest. 1993;104:254–258. - PubMed
-
- Loveridge B, West P, Kryger MH, Anthonisen NR. Alteration in breathing pattern with progression of chronic obstructive pulmonary disease. Am Rev Respir Dis. 1986;134:930–934. - PubMed
-
- Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26:948–968. - PubMed
-
- Nishimura K, Izumi T, Tsukino M, Oga T. Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD. Chest. 2002;121:1434–1440. - PubMed
-
- Jones PW, Adamek L, Nadeau G, Banik N. Comparisons of health status scores with MRC grades in COPD: implications for the GOLD 2011 classification. Eur Respir J. 2013;42:647–654. - PubMed
-
- Jones PW. COPD assessment test: rationale, development, validation and performance. COPD. 2013;10:269–271. - PubMed
-
- Reda AA, Kotz D, Kocks JW, Wesseling G, van Schayck CP. Reliability and validity of the clinical COPD questionnaire and chronic respiratory questionnaire. Respir Med. 2010;104:1675–1682. - PubMed
-
- Miller MR, Hankinson J, Brusasco V, et al. Standardization of spirom-etry. Eur Respir J. 2005;26:319–338. - PubMed
-
- Buist AS, Mcburnie MA, Vollmer WM, et al. International variations in the prevalence of COPD (the BOLD study): a population based prevalence study. Lancet. 2007;370:741–750. - PubMed
-
- Hurst JR, Vestbo J, Anzueto A, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med. 2010;363:1128–1138. - PubMed
-
- Soriano JB, Visick GT, Muellerova H, Payvandi N, Hansell AL. Patterns of comorbidities in newly diagnosed COPD and asthma in primary care. Chest. 2005;128:2099–2107. - PubMed
-
- Lange P, Nyboe J, Appleyard M, Jensen G, Schnohr P. Ventilatory function and chronic mucus hypersecretion as predictors of death from lung cancer. Am Rev Respir Dis. 1990;141:613–617. - PubMed
-
- Skillrud DM, Offord KP, Miller RD. Higher risk of lung cancer in chronic obstructive pulmonary disease: a prospective, matched, controlled study. Ann Intern Med. 1986;105:503–507. - PubMed
-
- Burgel PR, Roche N, Paillasseur JL, et al. Clinical COPD phenotypes identified by cluster analysis: validation with mortality. Eur Respir J. 2012;40:495–496. - PubMed
-
- Miravitlles M, Soler-Cataluña JJ, Calle M, et al. Spanish COPD guidelines (GesEPOC): pharmacological treatment of stable COPD. Arch Bronconeumol. 2012;48:247–257. - PubMed
-
- Garcia-Aymerich J, Gómez FP, Benet M, et al. Identification and prospective validation of clinically relevant chronic obstructive pulmonary disease (COPD) phenotypes. Thorax. 2011;66:430–437. - PubMed
-
- Sin DD, Miravitlles M, Mannino DM, et al. What is asthma-COPD overlap syndrome (ACOS)? Towards a consensus definition from a round table discussion. Eur Respir J. 2016;48:664–673. - PubMed
-
- Pascoe S, Locantore N, Dransfield MT, Barnes NC, Pavord ID. Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomized controlled trials. Lancet Respir Med. 2015;3:435–442. - PubMed
-
- Bafadhel M, Davies L, Calverley PM, Aaron SD, Brightling CE, Pavord ID. Blood eosinophil guided prednisolone therapy for exacerbations of COPD: a further analysis. Eur Respir J. 2014;44:789–791. - PubMed
-
- Fishman A, Martinez F, Naunheim K, et al. A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema. N Engl J Med. 2003;348:2059–2073. - PubMed
-
- Kelly AM, McAlpine R, Kyle E. How accurate are pulse oximeters in patients with acute exacerbations of chronic obstructive airways disease? Respir Med. 2001;95:336–340. - PubMed
-
- Pinto-Plata VM, Cote C, Cabral H, Taylor J, Celli BR. The 6-min walk distance: change over time and value as a predictor of survival in severe COPD. Eur Respir J. 2004;23:28–33. - PubMed
-
- Oga T, Nishimura K, Tsukino M, Sato S, Hajiro T. Analysis of the factors related to mortality in chronic obstructive pulmonary disease: role of exercise capacity and health status. Am J Respir Crit Care Med. 2003;167:544–549. - PubMed
-
- Celli BR, Cote CG, Marin JM, et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med. 2004;350:1005–1012. - PubMed
-
- Tashkin DP, Celli B, Senn S, et al. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med. 2008;359:1543–1554. - PubMed
-
- Calverley PM, Anderson JA, Celli B, et al. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med. 2007;356:775–789. - PubMed
-
- Decramer ML, Chapman KR, Dahl R, et al. Once-daily indacaterol versus tiotropium for patients with severe chronic obstructive pulmonary disease (INVIGORATE): a randomised, blinded, parallel-group study. Lancet Respir Med. 2013;1:524–533. - PubMed
-
- Vogelmeier C, Hederer B, Glaab T, et al. Tiotropium versus salmeterol for the prevention of exacerbations of COPD. N Engl J Med. 2011;364:1093–1103. - PubMed
-
- Wedzicha JA, Decramer M, Ficker JH, et al. Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): a randomised, double-blind, parallel-group study. Lancet Respir Med. 2013;1:199–209. - PubMed
-
- Wedzicha JA, Singh D, Vestbo J, et al. Extrafine beclomethasone/formoterol in severe COPD patients with history of exacerbations. Respir Med. 2014;108:1153–1162. - PubMed
-
- Loke YK, Cavallazzi R, Singh S. Risk of fractures with inhaled corticosteroids in COPD: systematic review and meta-analysis of randomised controlled trials and observational studies. Thorax. 2011;66:699–708. - PubMed
-
- Wang JJ, Rochtchina E, Tan AG, Cumming RG, Leeder SR, Mitchell P. Use of inhaled and oral corticosteroids and the long-term risk of cataract. Ophthalmology. 2009;116:652–657. - PubMed
-
- Suissa S, Kezouh A, Ernst P. Inhaled corticosteroids and the risks of diabetes onset and progression. Am J Med. 2010;123:1001–1006. - PubMed
-
- Lee CH, Kim K, Hyun MK, Jang EJ, Lee NR, Yim JJ. Use of inhaled corticosteroids and the risk of tuberculosis. Thorax. 2013;68:1105–1113. - PubMed
-
- Crim C, Dransfield MT, Bourbeau J, et al. Pneumonia risk with inhaled fluticasone furoate and vilanterol compared with vilanterol alone in patients with COPD. Ann Am Thorac Soc. 2015;12:27–34. - PubMed
-
- Wedzicha JA, Banerji D, Chapman KR, et al. Indacaterol-glyco-pyrronium versus salmeterol-fluticasone for COPD. N Engl J Med. 2016;374:2222–2234. - PubMed
-
- Welte T, Miravitlles M, Hernandez P, et al. Efficacy and tolerability of budesonide/formoterol added to tiotropium in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2009;180:741–750. - PubMed
-
- Singh D, Papi A, Corradi M, et al. Single inhaler triple therapy versus inhaled corticosteroid plus long-acting β2-agonist therapy for chronic obstructive pulmonary disease (TRILOGY): a double-blind, parallel group, randomised controlled trial. Lancet. 2016;388:963–973. - PubMed
-
- Martinez FJ, Calverley PM, Goehring UM, Brose M, Fabbri LM, Rabe KF. Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial. Lancet. 2015;385:857–866. - PubMed
-
- Hurst JR, Vestbo J, Anzueto A, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med. 2010;363:1128–1138. - PubMed
-
- Pascoe S, Locantore N, Dransfield M, Barnes NC, Pavord ID. Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials. Lancet Respir Med. 2015;3:435–442. - PubMed
-
- Spruit MA, Singh SJ, Garvey C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Resp Crit Care Med. 2013;188:e13–e64. - PubMed
-
- Garvey C, Bayles MP, Hamm LF, et al. Pulmonary rehabilitation exercise prescription in chronic obstructive pulmonary disease: review of selected guidelines. J Cardiopulm Rehabil Prev. 2016;6:75–83. - PubMed
-
- Ries AL, Make BJ, Lee SM, et al. The effects of pulmonary rehabilitation in the National Emphysema Treatment Trial. Chest. 2005;128:3799–3809. - PubMed
-
- Qaseem A, Wilt TJ, Weinberger SE, et al. Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society. Ann Intern Med. 2011;155:179–191. - PubMed
-
- Ortega F, Toal J, Cejudo P, et al. Comparison of effects of strength and endurance training in patients with chronic obstructive pulmonary disease. Am J Resp Crit Care Med. 2002;166:669–674. - PubMed
-
- Garber CE, Blissmer B, Deschenes MR, et al. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuro-motor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43:1334–1359. - PubMed
-
- Horowitz MB, Littenberg B, Mahler DA. Dyspnea ratings for prescribing exercise intensity in patients with COPD. Chest. 1996;109:1169–1175. - PubMed
-
- Scanlon PD, Connett JE, Waller LA, et al. Smoking cessation and lung function in mild-to-moderate chronic obstructive pulmonary disease: the Lung Health Study. Am J Respir Crit Care Med. 2000;161:381–390. - PubMed
-
- Carmody TP, Duncan C, Simon JA, et al. Hypnosis for smoking cessation: a randomized trial. Nicotine Tob Res. 2008;10:811–818. - PubMed
-
- Odum LE, O’Dell KA, Schepers JS. Electronic cigarettes: do they have a role in smoking cessation? J Pharm Pract. 2012;25:611–614. - PubMed
-
- Ferreira IM, Brooks D, White J, Goldstein R. Nutritional supplementation for stable COPD. Cochrane Database Syst Rev. 2012;12:CD000998. - PubMed
-
- Tiong LU, Davies R, Gibson PG, et al. Lung volume reduction surgery for diffuse emphysema. Cochrane Database Syst Rev. 2006:CD001001. - PubMed
-
- Weill D, Benden C, Corris PA, et al. A consensus document for the selection of lung transplant candidates – 2014: an update from the Pulmonary Transplantation Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2015;34:1–15. - PubMed
-
- International Society for Heart and Lung Transplantation Overall lung transplantation statistics. 2016. [Accessed July 19, 2017]. Available from: https://www.ishlt.org/registries/slides.asp?slides=heartLungRegistry.