Parry-Romberg syndrome in Kuwait. Neurological manifestations in 2 children

Affiliations


Abstract

Parry-Romberg syndrome is a rare disorder with progressive hemifacial atrophy of unknown etiology. We reported 2 cases of progressive hemifacial atrophy with different neurological manifestations from Kuwait. The first case was a 14-year-old boy who initially presented with recurrent transient stroke-like episodes followed by focal seizures and hemifacial atrophy. Magnetic resonance imaging showed significant white matter changes and cerebral hemiatrophy. The second case was a 7-year-old girl who presented with complex partial seizures and hemifacial atrophy, her magnetic resonance imaging scan showed minimal changes in the hemiatrophy of the temporal cerebral lobe. Both patients' disease activity was well controlled with immunosuppressive therapy and anticonvulsants. Parry-Romberg syndrome should be considered in any child with unexplained neurological symptoms.


Similar articles

Parry-Romberg syndrome: follow-up imaging during suppressive therapy.

Goldberg-Stern H, deGrauw T, Passo M, Ball WS Jr.Neuroradiology. 1997 Dec;39(12):873-6. doi: 10.1007/s002340050525.PMID: 9457714

[Association of Parry-Romberg syndrome and paroxymal kinesigenic dyskinesia].

Mrabet Khiari H, Masmoudi S, Mrabet A.Rev Neurol (Paris). 2009 May;165(5):489-92. doi: 10.1016/j.neurol.2008.08.003. Epub 2008 Oct 18.PMID: 18930510 French.

Parry Romberg's disease with intractable partial epilepsy.

Haldar A, Mukherjee A.Neurol India. 2007 Apr-Jun;55(2):160-2. doi: 10.4103/0028-3886.32791.PMID: 17558124

A unique case of progressive hemifacial microsomia or Parry-Romberg syndrome associated with limb and brain anomalies with normal neurological findings: A review of the literature.

Pattnaik A, Lim A, Sabeti S, Kwon A, Hall K, Lott I, Kimonis V.Eur J Med Genet. 2021 Sep;64(9):104234. doi: 10.1016/j.ejmg.2021.104234. Epub 2021 Jun 1.PMID: 34082156 Review.

Focal Epilepsy in a Teenager With Facial Atrophy and Hair Loss.

English SW, Ho ML, Tollefson MM, Wong-Kisiel LC.Semin Pediatr Neurol. 2018 Jul;26:68-73. doi: 10.1016/j.spen.2017.03.009. Epub 2017 Apr 2.PMID: 29961525 Review.


Cited by

Parry Romberg Syndrome in a Young Ghanaian: A Case Report and a Literature Review.

Dzefi-Tettey K, Edzie EK, Seadey MY, Brakohiapa EK, Asiamah S, Mensah SK, Kekeshie KK, Ntiamoah-Koufie CE, Agala DK, Acheampong F.Cureus. 2022 Dec 7;14(12):e32287. doi: 10.7759/cureus.32287. eCollection 2022 Dec.PMID: 36627986 Free PMC article.


References

  1.  
    1. Madasamy R, Jayanandan M, Adhavan UR, Gopalakrishnan S, Mahendra L. Parry Romberg syndrome:A case report and discussion. J Oral Maxillofac Pathol. 2012;16:406–410. - PMC - PubMed
  2.  
    1. Aydın H, Yologlu Z, Sargın H, Metin MR. Parry-Romberg syndrome. Physical, clinical, and imaging features. Neurosciences (Riyadh) 2015;20:368–371. - PMC - PubMed
  3.  
    1. El-Kehdy J, Abbas O, Rubeiz N. A review of Parry-Romberg syndrome. J Am Acad Dermatol. 2012;67:769–784. - PubMed
  4.  
    1. Trisal D, Kumar N, Dembla G, Sundriyal D. Parry-Romberg syndrome:uncommon but interesting. BMJ Case Rep 2014. 2014 - PMC - PubMed
  5.  
    1. Vix J, Mathis S, Lacoste M, Guillevin R, Neau JP. Neurological manifestations in Parry-Romberg syndrome:2 case reports. Medicine (Baltimore) 2015;94:e1147. - PMC - PubMed
  6.  
    1. Lis-Święty A, Brzezińska-Wcisło L, Arasiewicz H. Neurological abnormalities in localized scleroderma of the face and head:a case series study for evaluation of imaging findings and clinical course. Int J Neurosci. 2017;127:835–839. - PubMed
  7.  
    1. Amaral TN, Marques Neto JF, Lapa AT, Peres FA, Guirau CR, Appenzeller S. Neurologic involvement in scleroderma en coup de sabre. Autoimmune Dis 2012. 2012 719685. - PMC - PubMed
  8.  
    1. Kanzato N, Matsuzaki T, Komine Y, Saito M, Saito A, Yoshio T, et al. Localized scleroderma associated with progressing ischemic stroke. J Neurol Sci. 1999;163:86–89. - PubMed
  9.  
    1. Stone J. Parry-Romberg syndrome:a global survey of 205 patients using the Internet. Neurology. 2003;61:674–676. - PubMed
  10.  
    1. Guerrerosantos J, Guerrerosantos F, Orozco J. Classification and treatment of facial atrophy in Parry-Romberg disease. Aesthetic Plast Surg. 2007;31:424–434. - PubMed