Angiopoietin-like proteins in multiple sclerosis
Affiliations
Affiliations
- Human Genetics Unit, Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait. Electronic address: rabeah@hsc.edu.kw.
- Biochemistry and Molecular Biology Unit, Dasman Diabetes Institute, Kuwait City, Kuwait.
- Division of Neurology, Department of Medicine, Amiri Hospital, Kuwait.
Abstract
Angiopoietin-like proteins (ANGPTLs) are a group of proteins with functions in lipid metabolism, angiogenesis, and inflammation. Here, we investigated their involvement in multiple sclerosis (MS) progression and response to treatment in 100 MS patients and 77 healthy controls. ANGPTLs significantly associated with MS progression and response to therapy. High ANGPTL6 levels associated with slow disease progression and good response to fingolimod treatment and low ANGPTL4 associated with poor response to natalizumab treatment. Therefore, we propose high ANGPTL4 and 6 levels as markers for positive response to MS treatments either natalizumab or fingolimod respectively. Further investigations into their role in MS is warranted.
Keywords: Angiopoietin-like proteins; Fingolimod; Multiple sclerosis; Natalizumab.
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References
https://pubmed.ncbi.nlm.nih.gov/