Serotype distribution and penicillin-non-susceptibility of Streptococcus pneumoniae causing invasive diseases in Kuwait: A 10-year study of impact of pneumococcal conjugate vaccines
Affiliations
Affiliations
- a Faculty of Medicine, Department of Microbiology , Kuwait University , Jabriya , Kuwait.
Abstract
Objectives: The impact of PCV7 and PCV13 on pneumococcal infections in Kuwait is not known. Therefore we evaluated the impact on pneumococcal serotype distribution and penicillin-non-susceptibility in invasive infections in Kuwait.
Methods: Children < 2 y were given PCV7 from Aug 2006 to Jul 2010 (period I), and PCV13 from Aug 2010 to Jul 2013 (period II) with a pre-vaccination period from Aug 2003 to Jul 2006. Serotype and penicillin-non-susceptibility of blood and cerebrospinal fluid isolates from all ages were determined.
Results: In <2 y old children, even with a small number of infections, a drop in PCV7 serotypes was evident after vaccination. For all age groups combined, in the pre-vaccination period, PCV7, PCV13, PCV13 non-PCV7 serotypes and penicillin-non-susceptibility constituted 53.2%, 72.6%, 19.4% and 6.5% of the isolates respectively. PCV7, PCV13 non-PCV7 serotypes and penicillin-non-susceptibility changed to 32.7%, 28.2% and 7.3% (period I) and 6.6%, 22.2% and 8.9% (period II).
Conclusions: Vaccines reduced invasive infections due to PCV7 serotypes.
Keywords: Kuwait; Streptococcus pneumoniae; antibiotic resistance; invasive pneumococcal disease; pneumococcal conjugate vaccines; pneumococcal serotypes.
Similar articles
Mokaddas E, Albert MJ.Vaccine. 2012 Dec 31;30 Suppl 6:G37-40. doi: 10.1016/j.vaccine.2012.10.061.PMID: 23228356
Mokaddas EM, Shibl AM, Elgouhary A, Elsobky M.Vaccine. 2018 Oct 15;36(43):6442-6448. doi: 10.1016/j.vaccine.2018.07.067. Epub 2018 Sep 5.PMID: 30194003
Shibl AM, Memish ZA, Al-Kattan KM.Vaccine. 2012 Dec 31;30 Suppl 6:G32-6. doi: 10.1016/j.vaccine.2012.07.030.PMID: 23228355
Isaacman DJ, McIntosh ED, Reinert RR.Int J Infect Dis. 2010 Mar;14(3):e197-209. doi: 10.1016/j.ijid.2009.05.010. Epub 2009 Aug 22.PMID: 19700359 Review.
Picazo JJ.Clin Microbiol Infect. 2009 Apr;15 Suppl 3:4-6. doi: 10.1111/j.1469-0691.2009.02723.x.PMID: 19366362 Review.
Cited by
Mokaddas E, Syed S, Albert MJ.Hum Vaccin Immunother. 2021 Nov 2;17(11):4661-4666. doi: 10.1080/21645515.2021.1968216. Epub 2021 Aug 26.PMID: 34435932 Free PMC article.
Bizri AR, Althaqafi A, Kaabi N, Obeidat N, Al Akoury N, Haridy H.Infect Dis Ther. 2021 Jun;10(2):663-685. doi: 10.1007/s40121-021-00420-y. Epub 2021 Mar 22.PMID: 33751422 Free PMC article. Review.
Trends in antimicrobial susceptibility patterns in King Fahad Medical City, Riyadh, Saudi Arabia.
Farah SM, Alshehri MA, Alfawaz TS, Alasmeri FA, Alageel AA, Alshahrani DA.Saudi Med J. 2019 Mar;40(3):252-259. doi: 10.15537/smj.2019.3.23947.PMID: 30834420 Free PMC article.