Pemphigus in Kuwait
Affiliations
Affiliations
- As'ad Al-Hamad Dermatology Center, Al-Sabah Hospital, Kuwait.
Abstract
Background: Although pemphigus is a well-characterized entity, detailed epidemiologic studies from the Arabian Peninsula are not available. The purpose of this study was to elucidate the clinical features, course, and prognosis of pemphigus patients followed at a national dermatology center in Kuwait.
Methods: Fifty-four patients with pemphigus in this report were treated between 1981 and 1996, and were studied for several clinical features, treatment, course and prognosis.
Results: Around 80% of pemphigus patients were Arabs, and Kuwaitis constituted the largest number (46.3%) with a female predominance (F: M = 2:1). Pemphigus vulgaris (PV) was the commonest clinical type. The mean age of onset was 36 years. The follow-up period ranged from 2 months to 12 years (mean, 4.5 years). The majority of the patients could be managed with low-dose steroids (30-60 mg/day). Twenty per cent of the patients were in complete clinical remission and were off systemic therapy for an average of 3 years. No death secondary to the disease or its treatment was observed.
Conclusions: Kuwaiti patients with pemphigus were observed to have a relatively young age of onset and a female predominance. Low doses of steroids were enough to control the disease in the majority, and at least 20% of patients were off therapy and in complete remission on follow-up.
Similar articles
Long-term prognosis of pemphigus in Korea: retrospective analysis of 199 patients.
Kim MR, Kim HC, Kim SC.Dermatology. 2011;223(2):182-8. doi: 10.1159/000332848. Epub 2011 Oct 21.PMID: 22025028
Olszewska M, Kolacinska-Strasz Z, Sulej J, Labecka H, Cwikla J, Natorska U, Blaszczyk M.Am J Clin Dermatol. 2007;8(2):85-92. doi: 10.2165/00128071-200708020-00004.PMID: 17428113
Epidemiology of pemphigus in the western region of Turkey: retrospective analysis of 87 patients.
Bozdag K, Bilgin İ.Cutan Ocul Toxicol. 2012 Dec;31(4):280-5. doi: 10.3109/15569527.2011.653598. Epub 2012 Feb 7.PMID: 22309241
Pemphigus herpetiformis - a case report of a rare form of pemphigus and review of the literature.
Stojković-Filipović J, Lekić B, Milčić D, Milinković MV.Vojnosanit Pregl. 2016 Oct;73(10):967-72. doi: 10.2298/VSP150617044S.PMID: 29328564 Review.
Joly P, Sin C.Ann Dermatol Venereol. 2011 Mar;138(3):182-200. doi: 10.1016/j.annder.2011.01.016. Epub 2011 Feb 22.PMID: 21397148 Review. French.
Cited by
Rokni AM, Ayasse M, Ahmed A, Guggina L, Kantor RW, Silverberg JI.Arch Dermatol Res. 2023 Mar;315(2):207-213. doi: 10.1007/s00403-022-02346-y. Epub 2022 Mar 9.PMID: 35262797
Kavala M, Zindancı İ, Turkoglu Z, Kuru BC, Ozlu E, Simsek M.Postepy Dermatol Alergol. 2020 Feb;37(1):23-28. doi: 10.5114/ada.2020.93380. Epub 2020 Mar 9.PMID: 32467679 Free PMC article.
Autoimmune blistering diseases in females: a review.
Zhao CY, Murrell DF.Int J Womens Dermatol. 2015 Feb 26;1(1):4-12. doi: 10.1016/j.ijwd.2015.01.002. eCollection 2015 Feb.PMID: 28491949 Free PMC article. Review.
Suliman NM, Åstrøm AN, Ali RW, Salman H, Johannessen AC.BMC Oral Health. 2013 Nov 21;13:66. doi: 10.1186/1472-6831-13-66.PMID: 24261459 Free PMC article.
Epidemiology of pemphigus in tehran, iran: a 20-year retrospective study.
Abdolsamadi HR, Abdollahzadeh S, Bakianian Vaziri P, Beheshti A, Shafigh E, Vahedi M.J Dent Res Dent Clin Dent Prospects. 2007 Fall;1(3):108-13. doi: 10.5681/joddd.2007.019. Epub 2007 Dec 20.PMID: 23277844 Free PMC article.