1From the Department of Health Sciences (L.V.W., A.M.E., N. Shrine, C.B., T.B., M.D.T.), University of Leicester, United Kingdom.
2Department of Epidemiology (A.V., P.J.v.d.M., I.M.N., H. Snieder), University of Groningen, University Medical Center Groningen, The Netherlands.
3Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Iran (A.V.).
4Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, The Netherlands (R. Jansen).
5Hebrew SeniorLife, Harvard Medical School, Boston, MA (R. Joehanes).
6National Heart, Lung and Blood Institute's Framingham Heart Study, MA (R. Joehanes, A.D.J., M. Larson).
7Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre (C.P.N., P.S.B., N.J.S.), University of Leicester, United Kingdom.
8Institute of Psychiatry, Psychology and Neuroscience (P.F.O.), King's College London, United Kingdom.
9Clinical Pharmacology, William Harvey Research Institute (C.P.C., H.R.W., M.R.B., M. Brown, B.M., M.R., P.B.M., M.J.C.).
10NIHR Barts Cardiovascular Biomedical Research Unit (C.P.C., H.R.W., M.R.B., M. Brown, P.B.M., M.J.C.), Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom.
11Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA (L.M.R., F.G., P.M.R., D.I.C.).
12Department of Epidemiology (G.C.V., A. Hofman, A.G.U., O.H.F.), Erasmus MC, Rotterdam, The Netherlands.
13Department of Biological Psychology, Vrije Universiteit, Amsterdam, EMGO+ Institute, VU University Medical Center, The Netherlands (J.-J.H., E.J.d.G., G.W., D.I.B.).
14Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., M. Frånberg, A. Hamsten).
15Centre for Molecular Medicine, Karolinska Universitetsjukhuset, Solna, Sweden (R.J.S., M. Frånberg, A. Hamsten).
16Estonian Genome Center (T.E., E.O., A. Metspalu), University of Tartu, Estonia.
17Divisions of Endocrinology/Children's Hospital, Boston, MA (T.E.).
18Broad Institute of Harvard and MIT, Cambridge, MA (T.E., C.M.L., C.N.-C.).
19Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (D.E.A., P.N., A. Chakravarti, G.B.E.).
20The Population Science Branch, Division of Intramural Research, National Heart Lung and Blood Institute (S.-J.H., D.L.), National Institutes of Health, Bethesda, MD.
21The Framingham Heart Study, Framingham, MA (S.-J.H., D.L.).
22The Institute for Translational Genomics and Population Sciences, Department of Pediatrics (X.G., J.Y.), LABioMed at Harbor-UCLA Medical Center, Torrance, CA.
23Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland (Z.K., M. Bochud).
24Swiss Institute of Bioinformatics, Lausanne, Switzerland (Z.K.).
25Department of Cardiology (S. Trompet, J.W.J.), Leiden University Medical Center, The Netherlands.
26Institute for Community Medicine (A.T.), University Medicine Greifswald, Germany.
27DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Germany (A.T., M.D., U.V.).
28Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany (J.S.R., A. Peters).
29Cardiovascular Health Research Unit, Department of Medicine (J.C.B., B.M.P.), University of Washington, Seattle.
30Icelandic Heart Association, Kopavogur, Iceland (A.V.S., V. Gudnason).
31Faculty of Medicine, University of Iceland, Reykjavik, Iceland (A.V.S., V. Gudnason).
32Genetic Epidemiology Unit, Department of Epidemiology (N.A., B.A.O., C.M.v.D.), Erasmus MC, Rotterdam, The Netherlands.
33Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., T.L.).
34Department of Clinical Chemistry, Faculty of Medicine and Life Sciences, University of Tampere, Finland (L.-P.L., T.L.).
35Wellcome Trust Centre for Human Genetics (A. Mahajan, A.G., M. Farrall, T.F., C.M.L., H.W., A.P.M.), University of Oxford, United Kingdom.
36MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, United Kingdom (N.J.W., J.L., C.L., R.J.F.L., R.A.S., J.H.Z.).
37Clinical Division of Neurogeriatrics, Department of Neurology (E.H., R. Schmidt), Medical University Graz, Austria.
38Institute of Medical Informatics, Statistics and Documentation (E.H.), Medical University Graz, Austria.
39Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics (P.K.J., H.C., I.R., S.W., J.F.W.), University of Edinburgh, Scotland, United Kingdom.
40Department of Health (K.K., A.S.H., T. Niiranen, P.J., A.J., S. Koskinen, P.K., V.S., M.P.), Helsinki, Finland.
41Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy (M.T., C.M.B., C.F.S., D.T.).
42Division of Cardiovascular Medicine, Radcliffe Department of Medicine (A.G., M. Farrall, H.W.), University of Oxford, United Kingdom.
43Laboratory of Neurogenetics, National Institute on Aging (M.A.N.), National Institutes of Health, Bethesda, MD.
47Department of Medical, Surgical and Health Sciences, University of Trieste, Italy (D.V., I.G., M. Brumat, M. Cocca, A. Morgan, G.G., P.G.).
48Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy (F.D.G.M., P.P.P., A.S.P., A.A.H.).
49Department of Genetics and Genomic Sciences (K.L.A.), Icahn School of Medicine at Mount Sinai, New York.
50Cardiovascular Epidemiology and Genetics, IMIM, and CIBERCV, Barcelona, Spain (J. Marrugat, R.E.).
51Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Napoli, Italy (D.R., T. Nutile, R. Sorice, M. Ciullo).
52Centre for Cognitive Ageing and Cognitive Epidemiology (L.M.L., S.E.H., G.D., A.J.G., D.C.M.L., J.M.S., I.J.D.), University of Edinburgh, Scotland, United Kingdom.
53Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin (L.M.L.).
54UCD Conway Institute, Centre for Proteome Research (L.M.L.), University College Dublin, Belfield, Ireland.
55Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Sweden (S.E., Å. Johansson, U.G.).
56Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor (A.U.J., M. Boehnke).
57NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester United Kingdom (C.P.N., P.S.B., N.J.S.).
58MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (J.E.H., V.V., J. Marten, A.F.W., J.F.W.), University of Edinburgh, Western General Hospital, Scotland, United Kingdom.
59Department of Epidemiology and Biostatistics, School of Public Health (W.Z., E.E., J.C.C., H.G., B.L., I.T., A.-C.V.), Imperial College London, United Kingdom.
60Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, United Kingdom (W.Z., J.C.C., J.S.K.).
61Medical Genetics Section, Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine (S.E.H.), University of Edinburgh, Western General Hospital, Scotland, United Kingdom.
62Department of Medical Biology, Faculty of Medicine, University of Split, Croatia (T.Z.).
63The Charles Bronfman Institute for Personalized Medicine (Y.L., E.P.B., R.J.F.L.), Icahn School of Medicine at Mount Sinai, New York.
64Department of Hygiene and Epidemiology, University of Ioannina Medical School, Greece (E.E.).
65Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Scotland, United Kingdom (N. Shah, A.S.F.D., C.N.A.P.).
66Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan (N. Shah).
67Division of Nephrology, Department of Internal Medicine (M.H.d.B., M.A.S.), University of Groningen, University Medical Center Groningen, The Netherlands.
68Department of Twin Research and Genetic Epidemiology (M.M., C. Menni, T.D.S.), King's College London, United Kingdom.
69National Institute for Health Research Biomedical Research Centre, London, United Kingdom (M.M.).
70Department of Human Genetics, Wellcome Trust Sanger Institute, United Kingdom (B.P.P., E.Z.).
71Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine (A. Campbell), University of Edinburgh, Scotland, United Kingdom.
72Generation Scotland, Centre for Genomic and Experimental Medicine (A. Campbell, S.P., C.H.), University of Edinburgh, Scotland, United Kingdom.
73Department of Clinical Epidemiology (R.L.-G., R.d.M., D.O.M.-K.), Leiden University Medical Center, The Netherlands.
74INSERM U 1219, Bordeaux Population Health Center, France (G.C., C.T., S.D.).
75Bordeaux University, France (G.C., C.T., S.D.).
76Hunter Medical Research Institute, New Lambton, NSW, Australia (C.O., E.G.H., R. Scott, J.A.).
77Center for Statistical Genetics, Department of Biostatistics, Ann Arbor, MI (G.A.).
78Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Iran (M.A.).
79Busselton Population Medical Research Institute, Western Australia (J.B., J.H.).
80PathWest Laboratory Medicine of Western Australia, Nedlands (J.B., J.H.).
81School of Pathology and Laboratory Medicine (J.B., J.H.), The University of Western Australia, Nedlands.
82Imperial College Healthcare NHS Trust, London, United Kingdom (J.C.C., J.S.K.).
83Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute (F.C.), National Institutes of Health, Bethesda, MD.
84University of Dundee, Ninewells Hospital & Medical School, United Kingdom (J.C.).
85Institute of Genetic Medicine (H.J.C.), Newcastle University, Newcastle upon Tyne, United Kingdom.
86Department of Psychology (G.D., D.C.M.L., A. Pattie, I.J.D.), University of Edinburgh, Scotland, United Kingdom.
87Department of Molecular Epidemiology (J.D.), Leiden University Medical Center, The Netherlands.
88Center for Information Technology (Y.D., P.J.M., Q.T.N.), National Institutes of Health, Bethesda, MD.
89Department of Internal Medicine B (M.D.), University Medicine Greifswald, Germany.
90Department of Numerical Analysis and Computer Science, Stockholm University, Sweden (M. Frånberg).
91Department of Public Health and Caring Sciences, Geriatrics, Uppsala, Sweden (V. Giedraitis).
92Helmholtz Zentrum Muenchen, Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH), Neuherberg, Germany (C.G.).
93Department of Psychology, School of Social Sciences, Heriot-Watt University, Edinburgh, United Kingdom (A.J.G.).
94Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging (T.B.H., L.J.L.).
95Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (A. Hofman).
96School of Population and Global Health (J.H.), The University of Western Australia, Nedlands.
97MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health (M.-R.J., P.E.), Imperial College London, United Kingdom.
98Center For Life-Course Health Research (M.-R.J.), University of Oulu, Finland.
99Biocenter Oulu (M.-R.J.), University of Oulu, Finland.
100Unit of Primary Care, Oulu University Hospital, Finland (M.-R.J.).
101National Heart, Lung and Blood Institute, Cardiovascular Epidemiology and Human Genomics Branch, Bethesda, MD (A.D.J.).
102Department of Clinical Physiology, Tampere University Hospital, Finland (M.K.).
103Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Finland (M.K.).
104Cardiovascular Research Center (S. Kathiresan, C.N.-C.).
105Center for Human Genetics (S. Kathiresan), Massachusetts General Hospital, Boston.
106Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (S. Kathiresan, C.N.-C.).
107Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom (K.-T.K.).
108Department of Public Health, Faculty of Medicine, University of Split, Croatia (I.K., O.P.).
109Cardiology, Department of Specialties of Medicine, Geneva University Hospital, Switzerland (L. Lin, F.M., G.B.E.).
110Department of Medical Sciences, Cardiovascular Epidemiology (L. Lind, J.S.), Uppsala University, Sweden.
111Institute of Health and Society (C. Mamasoula), Newcastle University, Newcastle upon Tyne, United Kingdom.
112Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands (Y.M., B.W.J.H.P.).
113School of Molecular, Genetic and Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, Scotland, United Kingdom (A.D.M.).
114Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (A.C.M.).
115Interdisciplinary Center Psychopathology and Emotion Regulation (IPCE) (A.J.O., H.R., C.A.H.), University of Groningen, University Medical Center Groningen, The Netherlands.
116British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (S.P.), University of Glasgow, United Kingdom.
117Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland (A. Palotie, S.R., A.-P.S., M.P.).
118Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada (G.P., S. Thériault).
119School of Public Health (N.P.), Imperial College London, United Kingdom.
120Department of Neurology, General Central Hospital, Bolzano, Italy (P.P.P.).
121Department of Neurology, University of Lübeck, Germany (P.P.P.).
122Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland (O.T.R.).
123Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland (O.T.R.).
124Department of Cardiology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China (M.R.).
125Departments of Biostatistics (K.R.), University of Washington, Seattle.
126Harvard Medical School, Boston, MA (P.M.R., D.I.C.).
127Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy (A.R.).
128The Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine (J.I.R.), LABioMed at Harbor-UCLA Medical Center, Torrance, CA.
129Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Austria (Y.S., H. Schmidt).
130Faculty of Health, University of Newcastle, Callaghan, NSW, Australia (R. Scott, J.A.).
131John Hunter Hospital, New Lambton, NSW, Australia (R. Scott, J.A.).
132School of Medicine, Conway Institute (D.C.S.), University College Dublin, Belfield, Ireland.
133The New York Academy of Medicine, New York (D.S.).
134IRCCS Neuromed, Pozzilli, Isernia, Italy (R. Sorice, M. Ciullo).
135Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland (A.S.).
136Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), University of Glasgow, United Kingdom.
137Department of Genetics, (M.S.), University of Groningen, University Medical Center Groningen, The Netherlands.
138Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA (K.D.T.).
139Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (K.D.T.).
140International Centre for Circulatory Health (S. Thom), Imperial College London, United Kingdom.
141Department of Public Health (C.T.), Bordeaux University Hospital, France.
142Department of Internal Medicine (A.G.U.), Erasmus MC, Rotterdam, The Netherlands.
143Interfaculty Institute for Genetics and Functional Genomics (U.V.), University Medicine Greifswald, Germany.
144Department of Internal Medicine, Lausanne University Hospital, CHUV, Switzerland (P.V.).
145Population Health Research Institute, McMaster University, Hamilton Ontario, Canada (D.C.).
146National Heart and Lung Institute (P.S.), Imperial College London, United Kingdom.
147Department of Neurology (S.D.), Bordeaux University Hospital, France.
148Department of Public Health and Primary Care (D.O.M.-K.), Leiden University Medical Center, The Netherlands.
149Department of Cardiology (P.v.d.H.), University of Groningen, University Medical Center Groningen, The Netherlands.
150Mindich Child health Development Institute (R.J.F.L.), Icahn School of Medicine at Mount Sinai, New York.
151Alzheimer Scotland Dementia Research Centre (J.M.S.), University of Edinburgh, Scotland, United Kingdom.
152Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine (C.H.), University of Edinburgh, Scotland, United Kingdom.
153National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, United Kingdom (J.S.K.).
154Chronic Disease Prevention Unit (J.T.), Helsinki, Finland.
155National Institute for Health and Welfare (THL), Helsinki, Finland.
156Dasman Diabetes Institute, Kuwait (J.T.).
157Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia (J.T.).
158Department of Neurosciences and Preventive Medicine, Danube-University Krems, Austria (J.T.).
159Division of Cardiovascular Sciences, The University of Manchester and Central Manchester University Hospitals NHS Foundation Trust, United Kingdom (B.D.K.).
160Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem (Y.M.L.).
161Estonian Genome Center (M.P.), University of Tartu, Estonia.
162Department of Neurology (H. Schmidt), Medical University Graz, Austria.
163Epidemiology (B.M.P.), University of Washington, Seattle.
164Health Services (B.M.P.), University of Washington, Seattle.
165Kaiser Permanent Washington Health Research Institute, Seattle, WA (B.M.P.).
166Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany (R.R).
167School of Medicine and Pharmacology (A. James), The University of Western Australia, Nedlands.
168Department of Pulmonary Physiology and Sleep, Sir Charles Gairdner Hospital, Nedlands, Western Australia (A. James).
169Population Health Research Institute, St George's, University of London, United Kingdom (D.P.S.).
170Department of Medicine, Columbia University Medical Center, New York (W.P.).
171Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory (E.I.), Uppsala University, Sweden.
172Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA (E.I.).
173Center for Human Genetic Research (C.N.-C.), Massachusetts General Hospital, Boston.
174Data Science Institute and Lancaster Medical School, Lancaster University, United Kingdom (J.K.).
175Department of Biostatistics, University of Liverpool, United Kingdom (A.P.M.).
Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA. Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.
Ho JE, Levy D, Rose L, Johnson AD, Ridker PM, Chasman DI.J Hypertens. 2011 Jan;29(1):62-9. doi: 10.1097/HJH.0b013e3283406927.PMID: 21045733 Free PMC article.
Kurniansyah N, Goodman MO, Khan AT, Wang J, Feofanova E, Bis JC, Wiggins KL, Huffman JE, Kelly T, Elfassy T, Guo X, Palmas W, Lin HJ, Hwang SJ, Gao Y, Young K, Kinney GL, Smith JA, Yu B, Liu S, Wassertheil-Smoller S, Manson JE, Zhu X, Chen YI, Lee IT, Gu CC, Lloyd-Jones DM, Zöllner S, Fornage M, Kooperberg C, Correa A, Psaty BM, Arnett DK, Isasi CR, Rich SS, Kaplan RC, Redline S, Mitchell BD, Franceschini N, Levy D, Rotter JI, Morrison AC, Sofer T.Nat Commun. 2023 Jun 2;14(1):3202. doi: 10.1038/s41467-023-38990-9.PMID: 37268629 Free PMC article.
Ivanova T, Churnosova M, Abramova M, Ponomarenko I, Reshetnikov E, Aristova I, Sorokina I, Churnosov M.Int J Mol Sci. 2023 May 5;24(9):8309. doi: 10.3390/ijms24098309.PMID: 37176017 Free PMC article.
Ivanova T, Churnosova M, Abramova M, Plotnikov D, Ponomarenko I, Reshetnikov E, Aristova I, Sorokina I, Churnosov M.Int J Mol Sci. 2023 Apr 25;24(9):7799. doi: 10.3390/ijms24097799.PMID: 37175507 Free PMC article.
