Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
Evangelos Evangelou 1 2, Helen R Warren 3 4, David Mosen-Ansorena 1, Borbala Mifsud 3, Raha Pazoki 1, He Gao 1 5, Georgios Ntritsos 2, Niki Dimou 2, Claudia P Cabrera 3 4, Ibrahim Karaman 1, Fu Liang Ng 3, Marina Evangelou 1 6, Katarzyna Witkowska 3, Evan Tzanis 3, Jacklyn N Hellwege 7, Ayush Giri 8, Digna R Velez Edwards 8, Yan V Sun 9 10, Kelly Cho 11 12, J Michael Gaziano 11 12, Peter W F Wilson 13, Philip S Tsao 14, Csaba P Kovesdy 15, Tonu Esko 16 17, Reedik Mägi 16, Lili Milani 16, Peter Almgren 18, Thibaud Boutin 19, Stéphanie Debette 20 21, Jun Ding 22, Franco Giulianini 23, Elizabeth G Holliday 24, Anne U Jackson 25, Ruifang Li-Gao 26, Wei-Yu Lin 27, Jian'an Luan 28, Massimo Mangino 29 30, Christopher Oldmeadow 24, Bram Peter Prins 31, Yong Qian 22, Muralidharan Sargurupremraj 21, Nabi Shah 32 33, Praveen Surendran 27, Sébastien Thériault 34 35, Niek Verweij 17 36 37, Sara M Willems 28, Jing-Hua Zhao 28, Philippe Amouyel 38, John Connell 39, Renée de Mutsert 26, Alex S F Doney 32, Martin Farrall 40 41, Cristina Menni 29, Andrew D Morris 42, Raymond Noordam 43, Guillaume Paré 34, Neil R Poulter 44, Denis C Shields 45, Alice Stanton 46, Simon Thom 47, Gonçalo Abecasis 48, Najaf Amin 49, Dan E Arking 50, Kristin L Ayers 51 52, Caterina M Barbieri 53, Chiara Batini 54, Joshua C Bis 55, Tineka Blake 54, Murielle Bochud 56, Michael Boehnke 25, Eric Boerwinkle 57, Dorret I Boomsma 58, Erwin P Bottinger 59, Peter S Braund 60 61, Marco Brumat 62, Archie Campbell 63 64, Harry Campbell 65, Aravinda Chakravarti 50, John C Chambers 1 5 66 67 68, Ganesh Chauhan 69, Marina Ciullo 70 71, Massimiliano Cocca 72, Francis Collins 73, Heather J Cordell 51, Gail Davies 74 75, Martin H de Borst 76, Eco J de Geus 58, Ian J Deary 74 75, Joris Deelen 77, Fabiola Del Greco M 78, Cumhur Yusuf Demirkale 79, Marcus Dörr 80 81, Georg B Ehret 50 82, Roberto Elosua 83 84, Stefan Enroth 85, A Mesut Erzurumluoglu 54, Teresa Ferreira 86 87, Mattias Frånberg 88 89 90, Oscar H Franco 91, Ilaria Gandin 62, Paolo Gasparini 62 72, Vilmantas Giedraitis 92, Christian Gieger 93 94 95, Giorgia Girotto 62 72, Anuj Goel 40 41, Alan J Gow 74 96, Vilmundur Gudnason 97 98, Xiuqing Guo 99, Ulf Gyllensten 85, Anders Hamsten 88 89, Tamara B Harris 100, Sarah E Harris 63 74, Catharina A Hartman 101, Aki S Havulinna 102 103, Andrew A Hicks 78, Edith Hofer 104 105, Albert Hofman 91 106, Jouke-Jan Hottenga 58, Jennifer E Huffman 19 107 108, Shih-Jen Hwang 107 108, Erik Ingelsson 109 110, Alan James 111 112, Rick Jansen 113, Marjo-Riitta Jarvelin 1 5 114 115 116, Roby Joehanes 107 117, Åsa Johansson 85, Andrew D Johnson 107 118, Peter K Joshi 65, Pekka Jousilahti 102, J Wouter Jukema 119, Antti Jula 102, Mika Kähönen 120 121, Sekar Kathiresan 17 36 122, Bernard D Keavney 123 124, Kay-Tee Khaw 125, Paul Knekt 102, Joanne Knight 126, Ivana Kolcic 127, Jaspal S Kooner 5 67 68 128, Seppo Koskinen 102, Kati Kristiansson 102, Zoltan Kutalik 56 129, Maris Laan 130, Marty Larson 107, Lenore J Launer 100, Benjamin Lehne 1, Terho Lehtimäki 131 132, David C M Liewald 74 75, Li Lin 82, Lars Lind 133, Cecilia M Lindgren 40 87 134, YongMei Liu 135, Ruth J F Loos 28 59 136, Lorna M Lopez 74 137 138, Yingchang Lu 59, Leo-Pekka Lyytikäinen 131 132, Anubha Mahajan 40, Chrysovalanto Mamasoula 139, Jaume Marrugat 83, Jonathan Marten 19, Yuri Milaneschi 140, Anna Morgan 62, Andrew P Morris 40 141, Alanna C Morrison 142, Peter J Munson 79, Mike A Nalls 143 144, Priyanka Nandakumar 50, Christopher P Nelson 60 61, Teemu Niiranen 102 145, Ilja M Nolte 146, Teresa Nutile 70, Albertine J Oldehinkel 147, Ben A Oostra 49, Paul F O'Reilly 148, Elin Org 16, Sandosh Padmanabhan 64 149, Walter Palmas 150, Aarno Palotie 103 151 152, Alison Pattie 75, Brenda W J H Penninx 140, Markus Perola 102 103 153, Annette Peters 94 95 154, Ozren Polasek 127 155, Peter P Pramstaller 78 156 157, Quang Tri Nguyen 79, Olli T Raitakari 158 159, Meixia Ren 160, Rainer Rettig 161, Kenneth Rice 162, Paul M Ridker 23 163, Janina S Ried 94, Harriëtte Riese 147, Samuli Ripatti 103 164, Antonietta Robino 72, Lynda M Rose 23, Jerome I Rotter 99, Igor Rudan 65, Daniela Ruggiero 70 71, Yasaman Saba 165, Cinzia F Sala 53, Veikko Salomaa 102, Nilesh J Samani 60 61, Antti-Pekka Sarin 103, Reinhold Schmidt 104, Helena Schmidt 165, Nick Shrine 54, David Siscovick 166, Albert V Smith 97 98, Harold Snieder 146, Siim Sõber 130, Rossella Sorice 70, John M Starr 74 167, David J Stott 168, David P Strachan 169, Rona J Strawbridge 88 89, Johan Sundström 133, Morris A Swertz 170, Kent D Taylor 99, Alexander Teumer 81 171, Martin D Tobin 54, Maciej Tomaszewski 123 124, Daniela Toniolo 53, Michela Traglia 53, Stella Trompet 119 172, Jaakko Tuomilehto 173 174 175 176, Christophe Tzourio 21, André G Uitterlinden 91 177, Ahmad Vaez 146 178, Peter J van der Most 146, Cornelia M van Duijn 49, Anne-Claire Vergnaud 1, Germaine C Verwoert 91, Veronique Vitart 19, Uwe Völker 81 179, Peter Vollenweider 180, Dragana Vuckovic 62 181, Hugh Watkins 40 41, Sarah H Wild 182, Gonneke Willemsen 58, James F Wilson 19 65, Alan F Wright 19, Jie Yao 99, Tatijana Zemunik 183, Weihua Zhang 1 67, John R Attia 24, Adam S Butterworth 27 184, Daniel I Chasman 23 163, David Conen 185 186, Francesco Cucca 187 188, John Danesh 27 184, Caroline Hayward 19, Joanna M M Howson 27, Markku Laakso 189, Edward G Lakatta 190, Claudia Langenberg 28, Olle Melander 18, Dennis O Mook-Kanamori 26 191, Colin N A Palmer 32, Lorenz Risch 192 193 194, Robert A Scott 28, Rodney J Scott 24, Peter Sever 128, Tim D Spector 29, Pim van der Harst 195, Nicholas J Wareham 28, Eleftheria Zeggini 31, Daniel Levy 107 118, Patricia B Munroe 3 4, Christopher Newton-Cheh 134 196 197, Morris J Brown 3 4, Andres Metspalu 16, Adriana M Hung 198, Christopher J O'Donnell 199, Todd L Edwards 7, Bruce M Psaty 200 201, Ioanna Tzoulaki 1 2 5, Michael R Barnes 3 4, Louise V Wain 54 61, Paul Elliott 202 203 204 205 206, Mark J Caulfield 207 208; Million Veteran Program
Affiliations
Affiliations
- 1Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
- 2Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
- 3William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
- 4National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, London, UK.
- 5MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
- 6Department of Mathematics, Imperial College London, London, UK.
- 7Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
- 8Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center; Tennessee Valley Health Systems VA, Nashville, TN, USA.
- 9Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
- 10Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA.
- 11Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
- 12Division of Aging, Department of Medicine, Brigham and Women's Hospital; Department of Medicine, Harvard Medical School, Boston, MA, USA.
- 13Atlanta VAMC and Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA.
- 14VA Palo Alto Health Care System, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
- 15Nephrology Section, Memphis VA Medical Center and University of Tennessee Health Science Center, Memphis, TN, USA.
- 16Estonian Genome Center, University of Tartu, Tartu, Estonia.
- 17Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
- 18Department Clinical Sciences, Malmö, Lund University, Malmö, Sweden.
- 19MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.
- 20Department of Neurology, Bordeaux University Hospital, Bordeaux, France.
- 21Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, CHU Bordeaux, Bordeaux, France.
- 22Laboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD, USA.
- 23Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
- 24Hunter Medical Research Institute and Faculty of Health, University of Newcastle, New Lambton Heights, New South Wales, Australia.
- 25Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
- 26Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
- 27MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
- 28MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
- 29Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
- 30NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK.
- 31Wellcome Trust Sanger Institute, Hinxton, UK.
- 32Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
- 33Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan.
- 34Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
- 35Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, Quebec City, Quebec, Canada.
- 36Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.
- 37University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
- 38University of Lille, Inserm, Centre Hosp. Univ. Lille, Institut Pasteur de Lille, UMR1167 - RID-AGE - Risk factors and molecular determinants of aging-related diseases, Epidemiology and Public Health Department, Lille, France.
- 39University of Dundee, Ninewells Hospital & Medical School, Dundee, UK.
- 40Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
- 41Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
- 42Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
- 43Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
- 44Imperial Clinical Trials Unit, London, UK.
- 45School of Medicine, University College Dublin, Dublin, Ireland.
- 46Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
- 47International Centre for Circulatory Health, Imperial College London, London, UK.
- 48Center for Statistical Genetics, Department of Biostatistics, SPH II, Washington Heights, Ann Arbor, MI, USA.
- 49Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
- 50Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
- 51Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
- 52Sema4, a Mount Sinai venture, Stamford, CT, USA.
- 53Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
- 54Department of Health Sciences, University of Leicester, Leicester, UK.
- 55Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
- 56Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland.
- 57Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston and Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
- 58Department of Biological Psychology, Vrije Universiteit Amsterdam, EMGO+ Institute, VU University Medical Center, Amsterdam, the Netherlands.
- 59The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
- 60Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
- 61NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
- 62Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
- 63Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
- 64Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK.
- 65Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK.
- 66Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
- 67Department of Cardiology, Ealing Hospital, Middlesex, UK.
- 68Imperial College Healthcare NHS Trust, London, UK.
- 69Centre for Brain Research, Indian Institute of Science, Bangalore, India.
- 70Institute of Genetics and Biophysics "A. Buzzati-Traverso", CNR, Napoli, Italy.
- 71IRCCS Neuromed, Pozzilli, Isernia, Italy.
- 72Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.
- 73Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
- 74Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
- 75Department of Psychology, University of Edinburgh, Edinburgh, UK.
- 76Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
- 77Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
- 78Institute for Biomedicine, Eurac Research, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany.
- 79Mathematical and Statistical Computing Laboratory, Office of Intramural Research, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA.
- 80Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
- 81DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
- 82Cardiology, Department of Medicine, Geneva University Hospital, Geneva, Switzerland.
- 83CIBERCV & Cardiovascular Epidemiology and Genetics, IMIM, Barcelona, Spain.
- 84Faculty of Medicine, Universitat de Vic-Central de Catalunya, Vic, Spain.
- 85Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Uppsala, Sweden.
- 86Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
- 87Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK.
- 88Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
- 89Centre for Molecular Medicine, L8:03, Karolinska Universitetsjukhuset, Solna, Sweden.
- 90Department of Numerical Analysis and Computer Science, Stockholm University, Stockholm, Sweden.
- 91Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
- 92Department of Public Health and Caring Sciences, Geriatrics, Uppsala, Sweden.
- 93Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
- 94Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
- 95German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
- 96Department of Psychology, School of Social Sciences, Heriot-Watt University, Edinburgh, UK.
- 97Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
- 98Icelandic Heart Association, Kopavogur, Iceland.
- 99The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
- 100Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA.
- 101Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
- 102Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.
- 103Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
- 104Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
- 105Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
- 106Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
- 107National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.
- 108The Population Science Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
- 109Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
- 110Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
- 111Department of Pulmonary Physiology and Sleep, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia, Australia.
- 112School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.
- 113Department of Psychiatry, VU University Medical Center, Amsterdam Neuroscience, Amsterdam, the Netherlands.
- 114Biocenter Oulu, University of Oulu, Oulu, Finland.
- 115Center For Life-course Health Research, University of Oulu, Oulu, Finland.
- 116Unit of Primary Care, Oulu University Hospital, Oulu, Oulu, Finland.
- 117Hebrew SeniorLife, Harvard Medical School, Boston, MA, USA.
- 118Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
- 119Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
- 120Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
- 121Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
- 122Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
- 123Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
- 124Division of Medicine, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
- 125Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.
- 126Data Science Institute and Lancaster Medical School, Lancaster, UK.
- 127Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
- 128National Heart and Lung Institute, Imperial College London, London, UK.
- 129Swiss Institute of Bioinformatics, Lausanne, Switzerland.
- 130Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
- 131Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
- 132Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
- 133Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
- 134Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
- 135Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
- 136Mindich Child Health Development Institute, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
- 137Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.
- 138University College Dublin, UCD Conway Institute, Centre for Proteome Research, UCD, Belfield, Dublin, Ireland.
- 139Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
- 140Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, VU University Medical Center/GGZ inGeest, Amsterdam, the Netherlands.
- 141Department of Biostatistics, University of Liverpool, Liverpool, UK.
- 142Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
- 143Data Tecnica International, Glen Echo, MD, USA.
- 144Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
- 145Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland.
- 146Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
- 147Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
- 148SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
- 149British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
- 150Department of Medicine, Columbia University Medical Center, New York, NY, USA.
- 151Analytic and Translational Genetics Unit, Department of Medicine, Department of Neurology and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
- 152The Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- 153University of Tartu, Tartu, Estonia.
- 154German Center for Cardiovascular Disease Research (DZHK), partner site Munich, Neuherberg, Germany.
- 155Psychiatric Hospital "Sveti Ivan", Zagreb, Croatia.
- 156Department of Neurology, General Central Hospital, Bolzano, Italy.
- 157Department of Neurology, University of Lübeck, Lübeck, Germany.
- 158Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
- 159Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
- 160Fujian Key Laboratory of Geriatrics, Department of Geriatric Medicine, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China.
- 161Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany.
- 162Department of Biostatistics, University of Washington, Seattle, WA, USA.
- 163Harvard Medical School, Boston, MA, USA.
- 164Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
- 165Gottfried Schatz Research Center for Cell Signaling, Metabolism & Aging, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
- 166The New York Academy of Medicine, New York, NY, USA.
- 167Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
- 168Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK.
- 169Population Health Research Institute, St George's, University of London, London, UK.
- 170Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
- 171Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
- 172Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
- 173Dasman Diabetes Institute, Dasman, Kuwait.
- 174Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
- 175Department of Public Health, University of Helsinki, Helsinki, Finland.
- 176Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.
- 177Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.
- 178Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
- 179Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
- 180Department of Internal Medicine, University Hospital, CHUV, Lausanne, Switzerland.
- 181Experimental Genetics Division, Sidra Medical and Research Center, Doha, Qatar.
- 182Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK.
- 183Department of Biology, Faculty of Medicine, University of Split, Split, Croatia.
- 184The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
- 185Division of Cardiology, University Hospital, Basel, Switzerland.
- 186Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
- 187Institute of Genetic and Biomedical Research, National Research Council (CNR), Monserrato, Cagliari, Italy.
- 188Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
- 189Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
- 190Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
- 191Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.
- 192Labormedizinisches Zentrum Dr. Risch, Schaan, Liechtenstein.
- 193Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.
- 194University Institute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
- 195Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
- 196Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
- 197Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
- 198Tennessee Valley Healthcare System (Nashville VA) & Vanderbilt University, Nashville, TN, USA.
- 199VA Boston Healthcare, Section of Cardiology and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
- 200Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.
- 201Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
- 202Department of Epidemiology and Biostatistics, Imperial College London, London, UK. p.elliott@imperial.ac.uk.
- 203MRC-PHE Centre for Environment and Health, Imperial College London, London, UK. p.elliott@imperial.ac.uk.
- 204National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare NHS Trust and Imperial College London, London, UK. p.elliott@imperial.ac.uk.
- 205UK Dementia Research Institute (UK DRI) at Imperial College London, London, UK. p.elliott@imperial.ac.uk.
- 206Health Data Research-UK London substantive site, London, UK. p.elliott@imperial.ac.uk.
- 207William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. m.j.caulfield@qmul.ac.uk.
- 208National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, London, UK. m.j.caulfield@qmul.ac.uk.
Abstract
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
References
https://pubmed.ncbi.nlm.nih.gov/