Sensitivity of visual evoked potentials and spectral domain optical coherence tomography in early relapsing remitting multiple sclerosis

Affiliations


Abstract

Background: Visual evoked potentials and spectral-domain optical coherence tomography are common ancillary studies that assess the visual pathways from a functional and structural aspect, respectively.

Objective: To compare prevalence of abnormalities of Visual evoked potentials (VEP) and spectral-domain optical coherence tomography (SDOCT) in patients with relapsing remitting multiple sclerosis (RRMS).

Methods: A cross-sectional study of 100 eyes with disease duration of less than 5 years since the diagnosis. Correlation between retinal nerve fiber layer and ganglion-cell/inner plexiform layer with pattern-reversal visual evoked potentials amplitude and latency and contrast sensitivity was performed.

Results: The prevalence of abnormalities in pattern-reversal visual VEP was 56% while that of SOCT was 48% in all eyes. There was significant negative correlations between the average RNFL (r=-0.34, p=0.001) and GCIPL (r=-0.39, p<0.001) with VEP latency. In eyes with prior optic neuritis, a significant negative correlation was seen between average RNFL (r=-0.33, p=0.037) and GCIPL (r=-0.40, p=0.010) with VEP latency.

Conclusions: We have found higher prevalence of VEP abnormalities than SCOCT in early relapsing-remitting multiple sclerosis. This suggests that VEP has a higher sensitivity for detecting lesions of the visual pathway in patients with early RRMS.

Keywords: Axonal loss; Ganglion cell/inner plexiform layer; Multiple sclerosis; Optical coherence tomography; Retinal nerve fiber layer; Visual evoked potentials.


Similar articles

Optimization of spectral domain optical coherence tomography and visual evoked potentials to identify unilateral optic neuritis.

Behbehani R, Ali A, Al-Omairah H, Rousseff RT.Mult Scler Relat Disord. 2020 Jun;41:101988. doi: 10.1016/j.msard.2020.101988. Epub 2020 Feb 7.PMID: 32092503

Evaluation of the Innermost Retinal Layers and Visual Evoked Potentials in Patients with Multiple Sclerosis.

Esen E, Sizmaz S, Balal M, Yar K, Demirkiran M, Unal I, Demircan N.Curr Eye Res. 2016 Oct;41(10):1353-1358. doi: 10.3109/02713683.2015.1119283. Epub 2016 Feb 16.PMID: 26882356

Optical coherence tomography segmentation analysis in relapsing remitting versus progressive multiple sclerosis.

Behbehani R, Abu Al-Hassan A, Al-Salahat A, Sriraman D, Oakley JD, Alroughani R.PLoS One. 2017 Feb 13;12(2):e0172120. doi: 10.1371/journal.pone.0172120. eCollection 2017.PMID: 28192539 Free PMC article.

Optical coherence tomography in optic neuritis and multiple sclerosis: a review.

Kallenbach K, Frederiksen J.Eur J Neurol. 2007 Aug;14(8):841-9. doi: 10.1111/j.1468-1331.2007.01736.x.PMID: 17662003 Review.

Vision in multiple sclerosis: the story, structure-function correlations, and models for neuroprotection.

Sakai RE, Feller DJ, Galetta KM, Galetta SL, Balcer LJ.J Neuroophthalmol. 2011 Dec;31(4):362-73. doi: 10.1097/WNO.0b013e318238937f.PMID: 22089500 Free PMC article. Review.


Cited by

Utility of the visual system to monitor neurodegeneration in multiple sclerosis.

Mey GM, DeSilva TM.Front Mol Neurosci. 2023 Mar 29;16:1125115. doi: 10.3389/fnmol.2023.1125115. eCollection 2023.PMID: 37063369 Free PMC article. Review.

Functional-structural assessment of the optic pathways in patients with optic neuritis.

Schmidt MF, Pihl-Jensen G, Frederiksen JL.Doc Ophthalmol. 2020 Apr;140(2):159-168. doi: 10.1007/s10633-019-09728-0. Epub 2019 Oct 17.PMID: 31624975

Optical coherence tomography in multiple sclerosis.

Britze J, Frederiksen JL.Eye (Lond). 2018 May;32(5):884-888. doi: 10.1038/s41433-017-0010-2. Epub 2018 Feb 2.PMID: 29391574 Free PMC article. Review.

Clinically Isolated Syndrome According to McDonald 2010: Intrathecal IgG Synthesis Still Predictive for Conversion to Multiple Sclerosis.

Schwenkenbecher P, Sarikidi A, Bönig L, Wurster U, Bronzlik P, Sühs KW, Pul R, Stangel M, Skripuletz T.Int J Mol Sci. 2017 Sep 27;18(10):2061. doi: 10.3390/ijms18102061.PMID: 28953254 Free PMC article.


KMEL References