This cross-sectional study aimed to explore mental health disorders (MHD) prevalence among elderly diabetics in Indonesia. Data were extracted from the 2018 national basic health survey in Indonesia (abbreviated as RISKESDAS). The survey involved households randomly selected from 34 provinces, 416 districts, and 98 cities in Indonesia, with 1,017,290 respondents. The number of subjects selected in this study was 2818 elderly diabetic subjects. MHD was determined by self-reporting assessment. Secondary data acquired from RISKESDAS 2018 data involved age, sex, urban-rural residence status, marital status, educational level, employment status, obesity, hypertension, heart disease, stroke, family history of MHD, and DM duration. Binary logistic regression with a backward stepwise method was used to analyze the risk factors related to MHD. MHD prevalence among elderly diabetics in Indonesia was 19.3%. Factors associated with MHD among elderly diabetics were being female (prevalence odds ratio (POR) = 1.64; 95% CI: 1.126-2.394), married (POR = 0.05; 95% CI: 0.031-0.084), less education (POR = 3.37; 95% CI: 1.598-10.355), and stroke (POR = 1.61; 95% CI: 1.183-2.269). MHD prevalence among elderly diabetics in Indonesia was 19.3%, suggesting that screening for psychological problems and educating elderly diabetic patients is essential. Unmarried female elderly diabetics with less education and stroke were altogether more likely to experience MHD.
Asrullah M, L'Hoir M, Paulo MJ, Feskens EJM, Melse-Boonstra A.PLOS Glob Public Health. 2022 Mar 15;2(3):e0000232. doi: 10.1371/journal.pgph.0000232. eCollection 2022.PMID: 36962366 Free PMC article.
Xu X, Zhou Y, Su D, Dang Y, Zhang X.Int J Environ Res Public Health. 2023 Jan 10;20(2):1256. doi: 10.3390/ijerph20021256.PMID: 36674007 Free PMC article.
International Diabetes Federation . IDF Clinical Practice Recommendations for Managing Type 2 Diabetes in Primary Care. International Diabetes Federation; Brussel, Belgium: 2017. [(accessed on 17 July 2021)]. Available online: https://www.idf.org/e-library/guidelines/128-idf-clinical-practice-recom....
Robinson D.J., Luthra M., Vallis M. Diabetes and Mental Health. Can. J. Diabetes. 2013;37:S87–S92. doi: 10.1016/j.jcjd.2013.01.026. - DOI - PubMed
Khaledi M., Haghighatdoost F., Feizi A., Aminorroaya A. The prevalence of comorbid depression in patients with type 2 diabetes: An updated systematic review and meta-analysis on huge number of observational studies. Acta Diabetol. 2019;56:631–650. doi: 10.1007/s00592-019-01295-9. - DOI - PubMed
Roy T., Lloyd C.E. Epidemiology of depression and diabetes: A systematic review. J. Affect. Disord. 2012;142:S8–S21. doi: 10.1016/S0165-0327(12)70004-6. - DOI - PubMed
Khan P., Qayyum N., Malik F., Khan T., Khan M., Tahir A. Incidence of Anxiety and Depression Among Patients with Type 2 Diabetes and the Predicting Factors. Cureus. 2019;11 doi: 10.7759/cureus.4254. - DOI - PMC - PubMed
Sunny A.K., Khanal V.K., Sah R.B., Ghimire A. Depression among people living with type 2 diabetes in an urbanizing community of Nepal. PLoS ONE. 2019;14:e0218119. doi: 10.1371/journal.pone.0218119. - DOI - PMC - PubMed
De Sousa A., Lodha P. Geriatric Mental Heatlh: The challenges for India. J. Geriatr. Ment. Health. 2018;5:94–98. doi: 10.4103/jgmh.jgmh_34_17. - DOI
Bernstein C.M., Stockwell M.S., Gallagher M.P., Rosenthal S.L., Soren K. Mental health issues in adolescents and young adults with type 1 diabetes: Prevalence and impact on glycemic control. Clin. Pediatr. 2013;52:10–15. doi: 10.1177/0009922812459950. - DOI - PubMed
Sivertsen B., Petrie K.J., Wilhelmsen-Langeland A., Hysing M. Mental health in adolescents with Type 1 diabetes: Results from a large population-based study. BMC Endocr. Disord. 2014;14:83. doi: 10.1186/1472-6823-14-83. - DOI - PMC - PubMed
Eren I., Erdi Ö., Şahin M. The effect of depression on quality of life of patients with type II diabetes mellitus. Depress Anxiety. 2008;25:98–106. doi: 10.1002/da.20288. - DOI - PubMed
Smith K.J., Pedneault M., Schmitz N. Investigation of anxiety and depression symptom co-morbidity in a community sample with type 2 diabetes: Associations with indicators of self-care. Can. J. Public Health. 2015;106:e496–e501. doi: 10.17269/CJPH.106.5170. - DOI - PMC - PubMed
Bruce D.G., Davis W.A., Dragovic M., Davis T.M.E., Starkstein S.E. Comorbid Anxiety and Depression and Their Impact on Cardiovascular Disease in Type 2 Diabetes: The Fremantle Diabetes Study Phase II. Depress Anxiety. 2016;33:960–966. doi: 10.1002/da.22523. - DOI - PubMed
Hendriks S.M., Spijker J., Licht C.M.M., Beekman A.T.F., Hardeveld F., De Graaf R., Batelaan N.M., Penninx B.W.J.H. Disability in anxiety disorders. J. Affect. Disord. 2014;166:227–233. doi: 10.1016/j.jad.2014.05.006. - DOI - PubMed
Naicker K., Johnson J.A., Skogen J.C., Manuel D., Øverland S., Sivertsen B., Colman I. Type 2 diabetes and comorbid symptoms of depression and anxiety: Longitudinal associations with mortality risk. Diabetes Care. 2017;40:352–358. doi: 10.2337/dc16-2018. - DOI - PubMed
Yu M., Zhang X., Lu F., Fang L. Depression and Risk for Diabetes: A Meta-Analysis. Can. J. Diabetes. 2015;39:266–272. doi: 10.1016/j.jcjd.2014.11.006. - DOI - PubMed
Tiki T. Prevalence and Associated Factors of Depression among Type 2 Diabetes Mellitus Patients on Follow up at Ambo General Hospital, Oromia Regional State, Ethiopia, Institutional Based Cross Sectional Study. J. Depress Anxiety. 2017;6:1–5. doi: 10.4172/2167-1044.1000259. - DOI
Köhler C.A., Evangelou E., Stubbs B., Solmi M., Veronese N., Belbasis L., Bortolato B., Melo M.C., Coelho C.A., Fernandes B.S., et al. Mapping risk factors for depression across the lifespan: An umbrella review of evidence from meta-analyses and Mendelian randomization studies. J. Psychiatr. Res. 2018;103:189–207. doi: 10.1016/j.jpsychires.2018.05.020. - DOI - PubMed
Park C., Rosenblat J.D., Brietzke E., Pan Z., Lee Y., Cao B., Zuckerman H., Kalantarova A., McIntyre R.S. Stress, epigenetics and depression: A systematic review. Neurosci. Biobehav. Rev. 2019;102:139–152. doi: 10.1016/j.neubiorev.2019.04.010. - DOI - PubMed
Tsang R.S.M., Mather K.A., Sachdev P.S., Reppermund S. Systematic review and meta-analysis of genetic studies of late-life depression. Neurosci. Biobehav. Rev. 2017;75:129–139. doi: 10.1016/j.neubiorev.2017.01.028. - DOI - PubMed
Barnes J., Mondelli V., Pariante C.M. Genetic Contributions of Inflammation to Depression. Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol. 2017;42:81–98. doi: 10.1038/npp.2016.169. - DOI - PMC - PubMed
Mannan M., Mamun A., Doi S., Clavarino A. Prospective Associations between Depression and Obesity for Adolescent Males and Females- A Systematic Review and Meta-Analysis of Longitudinal Studies. PLoS ONE. 2016;11:e0157240. doi: 10.1371/journal.pone.0157240. - DOI - PMC - PubMed
Zimmermann U., Kraus T., Himmerich H., Schuld A., Pollmächer T. Epidemiology, implications and mechanisms underlying drug-induced weight gain in psychiatric patients. J. Psychiatr. Res. 2003;37:193–220. doi: 10.1016/S0022-3956(03)00018-9. - DOI - PubMed
Brayne C., Gao L., Matthews F. Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression. Neurobiol. Aging. 2005;26((Suppl. 1)):6–10. doi: 10.1016/j.neurobiolaging.2005.09.030. - DOI - PubMed
Alagiakrishnan K., Sclater A. Psychiatric disorders presenting in the elderly with type 2 diabetes mellitus. Am. J. Geriatr. Psychiatry Off. J. Am. Assoc. Geriatr. Psychiatry. 2012;20:645–652. doi: 10.1097/JGP.0b013e31823038db. - DOI - PubMed
Trief P.M. Depression in Elderly Diabetes Patients. Diabetes Spectr. 2007;20:71–75. doi: 10.2337/diaspect.20.2.71. - DOI
Bansal R., Singhal S., Dewangan G., Kumar P., Satpathy S., Kumar N., Dwivedi S.N., Dey A.B. Diabetic complications and poor mental health in the aging population. J. Geriatr. Ment. Health. 2019;6:78–83. doi: 10.4103/jgmh.jgmh_22_19. - DOI
Chen F., Wei G., Wang Y., Liu T., Huang T., Wei Q., Ma G., Wang D. Risk factors for depression in elderly diabetic patients and the effect of metformin on the condition. BMC Public Health. 2019;19:1063. doi: 10.1186/s12889-019-7392-y. - DOI - PMC - PubMed
Reuter A., Vollmer S., Aiyub A., Susanti S.S., Marthoenis M. Mental distress and its association with sociodemographic and economic characteristics: Community-based household survey in Aceh, Indonesia. BJ Psych. Open. 2020;6:e134. doi: 10.1192/bjo.2020.108. - DOI - PMC - PubMed
Irmansyah I., Dharmono S., Maramis A., Minas H. Determinants of psychological morbidity in survivors of the earthquake and tsunami in Aceh and Nias. Int. J. Ment. Health Syst. 2010;4:8. doi: 10.1186/1752-4458-4-8. - DOI - PMC - PubMed
Ganihartono I. Psychiatric Morbidity Among Patients Attending the Bangetayu Community Health Centre in Indonesia. Bul. Penelit. Kesehat. 1996;24:42–51.
Tamhane A.R., Westfall A.O., Burkholder G.A., Cutter G.R. Prevalence odds ratio versus prevalence ratio: Choice comes with consequences. Stat. Med. 2016;35:5730–5735. doi: 10.1002/sim.7059. - DOI - PMC - PubMed
Wang F., Wang S., Zong Q.-Q., Zhang Q., Ng C.H., Ungvari G.S., Xiang Y.-T. Prevalence of comorbid major depressive disorder in Type 2 diabetes: A meta-analysis of comparative and epidemiological studies. Diabet. Med. 2019;36:961–969. doi: 10.1111/dme.14042. - DOI - PubMed
McCombe G., Fogarty F., Swan D., Hannigan A., Fealy G.M., Kyne L., Meagher D., Cullen W. Identified mental disorders in older adults in primary care: A cross-sectional database study. Eur. J. Gen. Pract. 2018;24:84–91. doi: 10.1080/13814788.2017.1402884. - DOI - PMC - PubMed
Bădescu S.V., Tătaru C., Kobylinska L., Georgescu E.L., Zahiu D.M., Zăgrean A.M., Zăgrean L. The association between Diabetes mellitus and Depression. J. Med. Life. 2016;9:120–125. - PMC - PubMed
Raison C.L., Capuron L., Miller A.H. Cytokines sing the blues: Inflammation and the pathogenesis of depression. Trends Immunol. 2006;27:24–31. doi: 10.1016/j.it.2005.11.006. - DOI - PMC - PubMed
Arambewela M.H., Somasundaram N.P., Ranjan Jayasekara H.B.P., Kumbukage M.P. Prevalence of Depression and Associated Factors among Patients with Type 2 Diabetes Attending the Diabetic Clinic at a Tertiary Care Hospital in Sri Lanka: A Descriptive Study. Psychiatry J. 2019;2019:7468363. doi: 10.1155/2019/7468363. - DOI - PMC - PubMed
Ganasegeran K., Renganathan P., Manaf R.A., Al-Dubai S.A.R. Factors associated with anxiety and depression among type 2 diabetes outpatients in Malaysia: A descriptive cross-sectional single-centre study. BMJ Open. 2014;4:1–8. doi: 10.1136/bmjopen-2014-004794. - DOI - PMC - PubMed
Sweileh W.M., Abu-Hadeed H.M., Al-Jabi S.W., Zyoud S.H. Prevalence of depression among people with type 2 diabetes mellitus: A cross sectional study in Palestine. BMC Public Health. 2014;14:163. doi: 10.1186/1471-2458-14-163. - DOI - PMC - PubMed
Sweileh W.M., Abu-Hadeed H.M., Al-Jabi S.W., Sa’ed H.Z. Prevalence of depression and associated risk factors among persons with type-2 diabetes mellitus without a prior psychiatric history: A cross-sectional study in clinical settings in urban Nepal. BMC Psychiatry. 2013;13:309. doi: 10.1186/1471-244X-13-309. - DOI - PMC - PubMed
Baumeister H., Härter M. Prevalence of mental disorders based on general population surveys. Soc. Psychiatry Psychiatr. Epidemiol. 2007;42:537–546. doi: 10.1007/s00127-007-0204-1. - DOI - PubMed
Madkhali J.M., Hakami A.A., Dallak A.H., Hakami R.M., Yatimi A.A., Hamdi M.E., Bakkari H.A., Kariri K.I., Abiri J.M., Ahmed A.E., et al. Prevalence and Associated Factors of Depression among Patients with Diabetes at Jazan Province, Saudi Arabia: A Cross-Sectional Study. Psychiatry J. 2019;2019:6160927. doi: 10.1155/2019/6160927. - DOI - PMC - PubMed
Kara B., Açıkel C.H. Predictors of coping in a group of Turkish patients with physical disability. J. Clin. Nurs. 2012;21:983–993. doi: 10.1111/j.1365-2702.2011.03890.x. - DOI - PubMed
Anandakumar D., Ratnatunga S.S., Dayabandara M., Hanwella R., de Silva V.A. Depressive disorder in patients attending the outpatient department of a tertiary care hospital in Colombo. Ceylon Med. J. 2016;61:118–122. doi: 10.4038/cmj.v61i3.8347. - DOI - PubMed
Xu X., Mishra G.D., Dobson A.J., Jones M. Progression of diabetes, heart disease, and stroke multimorbidity in middle-aged women: A 20-year cohort study. PLoS Med. 2018;15:e1002516. doi: 10.1371/journal.pmed.1002516. - DOI - PMC - PubMed
Lontchi-Yimagou E., Sobngwi E., Matsha T.E., Kengne A.P. Diabetes mellitus and inflammation. Curr. Diab. Rep. 2013;13:435–444. doi: 10.1007/s11892-013-0375-y. - DOI - PubMed
Smith G. Step away from stepwise. J. Big Data. 2018;5:32. doi: 10.1186/s40537-018-0143-6. - DOI