Applications and efficiencies of the first cat 63K DNA array
Barbara Gandolfi 1, Hasan Alhaddad 2, Mona Abdi 3, Leslie H Bach 4 5, Erica K Creighton 1, Brian W Davis 6, Jared E Decker 7, Nicholas H Dodman 8, Edward I Ginns 9, Jennifer C Grahn 4 10, Robert A Grahn 4 10, Bianca Haase 11, Jens Haggstrom 12, Michael J Hamilton 4 13, Christopher R Helps 14, Jennifer D Kurushima 4 15, Hannes Lohi 16, Maria Longeri 17, Richard Malik 18, Kathryn M Meurs 19, Michael J Montague 20, James C Mullikin 21, William J Murphy 6, Sara M Nilson 7, Niels C Pedersen 22, Carlyn B Peterson 4, Clare Rusbridge 23, Rashid Saif 24, G Diane Shelton 25, Wesley C Warren 26, Muhammad Wasim 27, Leslie A Lyons 28
Affiliations
Affiliations
- 1Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri - Columbia, Columbia, MO, USA.
- 2Department of Biological Sciences, Kuwait University, Safat, Kuwait. hhalhaddad@gmail.com.
- 3Department of Biological Sciences, Kuwait University, Safat, Kuwait.
- 4Department of Population Health and Reproduction, School of Veterinary Medicine, University of California - Davis, Davis, CA, USA.
- 5University of San Francisco, San Francisco, CA, USA.
- 6Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.
- 7Division of Animal Sciences, University of Missouri - Columbia, Columbia, MO, USA.
- 8Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.
- 9Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA.
- 10Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California - Davis, Davis, CA, USA.
- 11Sydney School of Veterinary Science, University of Sydney, Sydney, Australia.
- 12Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
- 13Department of Biochemistry, University of California - Riverside, Riverside, CA, USA.
- 14Langford Vets, University of Bristol, Bristol, United Kingdom.
- 15Foothill College, Los Altos Hills, CA, USA.
- 16Department of Veterinary Biosciences, Research Programs Unit, Molecular Neurology, University of Helsinki, and The Folkhälsan Institute of Genetics, Helsinki, Finland.
- 17Department of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy.
- 18Centre for Veterinary Education, University of Sydney, New South Wales, Australia.
- 19Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
- 20Department of Neuroscience, Parelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
- 21NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
- 22Center for Companion Animal Health, School of Veterinary Medicine, University of California - Davis, Davis, CA, USA.
- 23School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, United Kingdom.
- 24Institute of Biotechnology, Gulab Devi Educational Complex, Lahore, Pakistan.
- 25Department of Pathology, University of California, San Diego, La Jolla, CA, USA.
- 26McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, USA.
- 27Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
- 28Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri - Columbia, Columbia, MO, USA. lyonsla@missouri.edu.
Abstract
The development of high throughput SNP genotyping technologies has improved the genetic dissection of simple and complex traits in many species including cats. The properties of feline 62,897 SNPs Illumina Infinium iSelect DNA array are described using a dataset of over 2,000 feline samples, the most extensive to date, representing 41 cat breeds, a random bred population, and four wild felid species. Accuracy and efficiency of the array's genotypes and its utility in performing population-based analyses were evaluated. Average marker distance across the array was 37,741 Kb, and across the dataset, only 1% (625) of the markers exhibited poor genotyping and only 0.35% (221) showed Mendelian errors. Marker polymorphism varied across cat breeds and the average minor allele frequency (MAF) of all markers across domestic cats was 0.21. Population structure analysis confirmed a Western to Eastern structural continuum of cat breeds. Genome-wide linkage disequilibrium ranged from 50-1,500 Kb for domestic cats and 750 Kb for European wildcats (Felis silvestris silvestris). Array use in trait association mapping was investigated under different modes of inheritance, selection and population sizes. The efficient array design and cat genotype dataset continues to advance the understanding of cat breeds and will support monogenic health studies across feline breeds and populations.
Conflict of interest statement
The authors declare no competing interests.
Figures
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