A population-based study of the epidemiology and the risk factors for male infertility in Kuwait

Ahmed M Al-Kandari 1, Ahmad N Al-Enezi 2, Hamdy Ibrahim 3, Omar Alkandari 4

Affiliations

12 January 2020

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doi: 10.4103/UA.UA_50_20

Abstract

Purpose: Infertility has become one of the foremost public health concerns, affecting a large number of couples. This research aimed to study and analyze the epidemiological data of male infertility including demographic characteristics and potential accountable factors.

Materials and methods: A population-based study was carried out among male patients of one center. Different factors have been investigated such as family history, smoking, and varicocele. Data were analyzed using the STATA statistical software package.

Results: A total of 608 male patients aged between 22 and 56 years were included. Out of them, there were 544 (89.95%) married, 48 (7.9%) married more than once, and 10 (1.6%) divorced. Primary infertility was noted in 478 (78.6%) patients. The most commonly reported sexual disorder was erectile dysfunction 53 (8.7%), while decreased libido was detected in 8 (1.3%) patients. Varicocele was present among 507 (86%) patients. Semen analyses of infertile patients revealed that 43 (8.2%) cases had normal semen tests. In contrast, oligoasthenospermia was the most commonly reported semen abnormality 158 (30.2%). A total of 198 patients underwent assisted reproductive technique.

Conclusion: This study concluded that primary infertility is the most common type among all infertile male patients who visited our center. The risk factors of male infertility include positive family history, smoking, and varicocele.

Keywords: Male infertility; smoking; varicocele.

Conflict of interest statement

There are no conflicts of interest.

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References

  1.  
    1. Mohammed F, Al-Yatama F, Al-Bader M, Tayel S, Gouda S, Naguib K. Primary male infertility in Kuwait: A cytogenetic and molecular study of 289 infertile Kuwaiti patients. Andrologia. 2007;39:87–92. - PubMed
  2.  
    1. Collins HP, Kalisch D. The Health of Australia's Males Health. Canberra: Australian Institute of Health and Welfare; 2011.
  3.  
    1. Jungwirth A, Giwercman A, Tournaye H, Diemer T, Kopa Z, Dohle G Infertility E W G O M. European Association of Urology guidelines on Male Infertility: The 2012 update. Eur Urol. 2012;62:324–32. - PubMed
  4.  
    1. Martinez G, Daniels K, Chandra A. Fertility of men and women aged 15-44 years in the United States: National Survey of Family Growth, 2006-2010. Natl Health Stat Report. 2012:1–28. - PubMed
  5.  
    1. Rutstein SO, Shah IH. Infecundity Infertility and Childlessness in Developing Countries DHS program by US Aid. USA: 2004.
  6.  
    1. Matetakufa S. Our own gift. New Int. 1998;303:11–2.
  7.  
    1. Kim YS, Kim SK, Cho IC, Min SK. Efficacy of scrotal Doppler ultrasonography with the Valsalva maneuver, standing position, and resting-Valsalva ratio for varicocele diagnosis. Korean J Urol. 2015;56:144–9. - PMC - PubMed
  8.  
    1. Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HW, Behre HM, et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update. 2010;16:231–45. - PubMed
  9.  
    1. Qadan LR, Ahmed AA, Kapila KA, Hassan NA, Kodaj JA, Pathan SK. Male infertility in Kuwait. Etiologic and therapeutic aspects. Saudi Med J. 2007;28:96–9. - PubMed
  10.  
    1. McIntyre M, Hsieh TC, Lipshultz L. Varicocele repair in the era of modern assisted reproductive techniques. Curr Opinion Urol. 2012;22:517–20. - PubMed
  11.  
    1. Kovac JR, Khanna A, Lipshultz LI. The effects of cigarette smoking on male fertility. Postgrad Med. 2015;127:338–41. - PMC - PubMed
  12.  
    1. Ranganathan P, Rao KA, Sudan JJ, Balasundaram S. Cadmium effects on sperm morphology and semenogelin with relates to increased ROS in infertile smokers: An in vitro and in silico approach. Reprod Biol. 2018;18:189–97. - PubMed
  13.  
    1. Nadeem F, Fahim A, Bugti S. Effects of cigarette smoking on male fertility. Turk J Med Sci. 2012;42(Suppl 2):1400–5.
  14.  
    1. ElBardisi H, Arafa M, Rengan A, Durairajanayagam D, AlSaid S, Khalafalla K, et al. Varicocele among infertile men in Qatar. Andrologia. 2017;49:e12637. - PubMed
  15.  
    1. Baazeem A, Belzile E, Ciampi A, Dohle G, Jarvi K, Salonia A, et al. Varicocele and male factor infertility treatment: A new meta-analysis and review of the role of varicocele repair. Eur Urol. 2011;60:796–808. - PubMed
  16.  
    1. Jarow JP. Effects of varicocele on male fertility. Hum Reprod Update. 2001;7:59–64. - PubMed
  17.  
    1. Gomaa MD, Motawaa MA, Al-Nashar AM, El-Sakka AI. Impact of Subinguinal varicocelectomy on serum testosterone to estradiol ratio in male patients with infertility. Urology. 2018;117:70–7. - PubMed
  18.  
    1. Punab M, Poolamets O, Paju P, Vihljajev V, Pomm K, Ladva R, et al. Causes of male infertility: A 9-year prospective monocentre study on 1737 patients with reduced total sperm counts. Hum Reprod. 2017;32:18–31. - PMC - PubMed
  19.  
    1. Irvine DS. Epidemiology and etiology of male infertility. Hum Reprod. 1998;13(Suppl 1):33–44. - PubMed
  20.  
    1. Omu AE. Sperm parameters: Paradigmatic index of good health and longevity. Med Princ Pract. 2013;22(Suppl 1):30–42. - PMC - PubMed
  21.  
    1. Al-Faisal AH. Hormonal disturbances among the infertile men in Baghdad-Iraq. J Med Tech Assoc Thailand. 2010;38:3060–6.
  22.  
    1. Eldamnhoury E, Elatrash G, Rashwan H, El-Sakka A. Association between leukocytospermia and semen interleukin-6 and tumor necrosis factor-alpha in infertile men. Andrology. 2018;6:775–80. - PubMed
  23.  
    1. Krausz C, Escamilla AR, Chianese C. Genetics of male infertility: From research to clinic. Reproduction. 2015;150:R159–74. - PubMed
  24.  
    1. Alkhalaf M, Verghese L, Muharib N. A cytogenetic study of Kuwaiti couples with infertility and reproductive disorders: Short arm deletion of chromosome 21 is associated with male infertility. Ann Genet. 2002;45:147–9. - PubMed
  25.  
    1. El-Sakka AI. Routine assessment of sperm DNA fragmentation in clinical practice: Commentary and perspective. Transl Androl Urol. 2017;6:S640–3. - PMC - PubMed
  26.  
    1. Evenson DP. Sperm chromatin structure assay (SCSA(R)) Methods Mol Biol. 2013;927:147–64. - PubMed
  27.  
    1. Evgeni E, Charalabopoulos K, Asimakopoulos B. Human sperm DNA fragmentation and its correlation with conventional semen parameters. J Reprod Infertil. 2014;15:2–14. - PMC - PubMed
  28.  
    1. Lotti F, Maggi M. Sexual dysfunction and male infertility. Nat Rev Urol. 2018;15:287–307. - PubMed
  29.  
    1. Mehta A, Bolyakov A, Schlegel PN, Paduch DA. Higher pregnancy rates using testicular sperm in men with severe oligospermia. Fertil Steril. 2015;104:1382–7. - PubMed
  30.  
    1. Piva I, Lo Monte G, Graziano A, Marci R. A literature review on the relationship between infertility and sexual dysfunction: Does fun end with baby making? Eur J Contracept Reprod Health Care. 2014;19:231–7. - PubMed

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