Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression
Rita Nahta 1, Fahd Al-Mulla 2, Rabeah Al-Temaimi 2, Amedeo Amedei 3, Rafaela Andrade-Vieira 4, Sarah N Bay 5, Dustin G Brown 6, Gloria M Calaf 7, Robert C Castellino 8, Karine A Cohen-Solal 9, Annamaria Colacci 10, Nichola Cruickshanks 11, Paul Dent 11, Riccardo Di Fiore 12, Stefano Forte 13, Gary S Goldberg 14, Roslida A Hamid 15, Harini Krishnan 14, Dale W Laird 16, Ahmed Lasfar 17, Paola A Marignani 4, Lorenzo Memeo 13, Chiara Mondello 18, Christian C Naus 19, Richard Ponce-Cusi 20, Jayadev Raju 21, Debasish Roy 22, Rabindra Roy 23, Elizabeth P Ryan 6, Hosni K Salem 24, A Ivana Scovassi 18, Neetu Singh 25, Monica Vaccari 10, Renza Vento 26, Jan Vondráček 27, Mark Wade 28, Jordan Woodrick 23, William H Bisson 29
Affiliations
Affiliations
- 1Departments of Pharmacology and Hematology & Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA 30322, USA, Department of Pathology, Kuwait University, Safat 13110, Kuwait, Department of Experimental and Clinical Medicine, University of Firenze, 50134 Florence, Italy, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada, Program in Genetics and Molecular Biology, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA, Department of Environmental and Radiological Health Sciences/Colorado State University/Colorado School of Public Health, Fort Collins, CO 80523-1680, USA, Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA, Instituto de Alta Investigacion, Universidad de Tarapaca, Arica 8097877, Chile, Division of Hematology and Oncology, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30322, USA, Department of Medicine/Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901-1914, USA, Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna 40126, Italy, Departments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 980033, USA, Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, 90127 Palermo, Italy, Mediterranean Institute of Oncology, 95029 Viagrande, Italy, Graduate School of Biomedical Sciences and Department of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084-1501, USA, Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra, Serdang, Selangor 43400, Malaysia, Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontari
- 2Department of Pathology, Kuwait University, Safat 13110, Kuwait.
- 3Department of Experimental and Clinical Medicine, University of Firenze, 50134 Florence, Italy.
- 4Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
- 5Program in Genetics and Molecular Biology, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA.
- 6Department of Environmental and Radiological Health Sciences/Colorado State University/Colorado School of Public Health, Fort Collins, CO 80523-1680, USA.
- 7Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA, Instituto de Alta Investigacion, Universidad de Tarapaca, Arica 8097877, Chile.
- 8Division of Hematology and Oncology, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30322, USA.
- 9Department of Medicine/Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901-1914, USA.
- 10Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna 40126, Italy.
- 11Departments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 980033, USA.
- 12Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, 90127 Palermo, Italy.
- 13Mediterranean Institute of Oncology, 95029 Viagrande, Italy.
- 14Graduate School of Biomedical Sciences and Department of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084-1501, USA.
- 15Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra, Serdang, Selangor 43400, Malaysia.
- 16Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada.
- 17Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ 60503, USA.
- 18Institute of Molecular Genetics, National Research Council, 27100 Pavia, Italy.
- 19Department of Cellular & Physiological Sciences, Life Sciences Institute, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
- 20Instituto de Alta Investigacion, Universidad de Tarapaca, Arica 8097877, Chile.
- 21Toxicology Research Division, Bureau of Chemical Safety Food Directorate, Health Products and Food Branch Health Canada, Ottawa, Ontario K1A0K9, Canada.
- 22Department of Natural Science, The City University of New York at Hostos Campus, Bronx, NY 10451, USA.
- 23Molecular Oncology Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA.
- 24Urology Dept., kasr Al-Ainy School of Medicine, Cairo University, El Manial, Cairo 12515, Egypt.
- 25Advanced Molecular Science Research Centre, King George's Medical University, Lucknow, UP 226003, India.
- 26Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, 90127 Palermo, Italy, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.
- 27Department of Cytokinetics, Institute of Biophysics AS CR, Brno 612 65, Czech Republic.
- 28Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT), Milan 16163, Italy and.
- 29Environmental and Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331, USA.
Abstract
As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.
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