Laparoscopic donor nephrectomy: The Middle East experience

Affiliations

03 January 2012

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doi: 10.1016/j.aju.2012.01.007


Abstract

Objectives: To summarize the experience of the Middle East in laparoscopic donor nephrectomy (LDN), to discuss the associated advantages and salient problems, to examine the learning curve encountered compared with that of the pioneering centres in the West, and the contribution of the regional centres to the worldwide experience.

Methods: We searched Medline and PubMed for all centres performing LDN in the Middle East. Questionnaires were e-mailed to the regional transplantation centres, and programme directors, and leading urological and transplant surgeons were contacted by telephone.

Results: LDN in the Middle East was first introduced in 2000; this approach has been pioneered and practised at seven transplant centres within five countries in the region, and was restricted to only three Arab countries, i.e. Lebanon, Egypt and Kuwait. Data collection yielded a total of 888 procedures over one decade, representing only 2% of the total of ≈50,000 transplants during the same period. Despite variability of accurate reporting the overall outcomes were similar to those of open DN. The spectrum of complications was comparable to that from major centres in the USA during their learning curve.

Conclusions: The introduction of LDN in the Middle East has been gratifying. The relative hesitancy in introducing LDN in the rest of the Arab Middle East is multifaceted. The advantages conferred to the donor underscore the need for further expansion of this approach for kidney retrieval.

Keywords: (L)(O)DN, (laparoscopic) (open) donor nephrectomy; ATN, acute tubular necrosis; AUBMC, American University of Beirut Medical Center; Complications; Laparoscopic donor nephrectomy; MESOT, Middle East Society for Organ Transplantation; Middle East; Transplantation.


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KMEL References


References

  1.  
    1. Ratner L.E., Ciseck L.J., Moore R.G., Cigarroa F.G., Kaufman H.S., Kavoussi L.R. Laparoscopic live donor nephrectomy. Transplantation. 1995;60:1047–1049. - PubMed
  2.  
    1. Flowers J.L., Jacobs S., Cho E., Morton A., Rosenberger W.F., Evans D. Comparison of open and laparoscopic live donor nephrectomy. Ann Surg. 1997;226:483–489. - PMC - PubMed
  3.  
    1. Detry O., Defechereux T., Hamoir E., de Roover A., Bonnet P., Honoré P. Transplantation of a kidney harvested laparoscopically from a related living donor. Rev Med Liege. 1998;53:657–659. - PubMed
  4.  
    1. Berney T., Malaise J., Mourad M., Morel P., Squifflet J.P. Laparoscopic and open live donor nephrectomy: a cost benefit study. Transp Int. 2000;13:35–40. - PubMed
  5.  
    1. Wolf J.S., Jr., Marcovich R., Merion R.M., Konnak J.W. Prospective, case matched comparison of hand assisted laparoscopic and open surgical live donor nephrectomy. J Urol. 2000;163:1650–1653. - PubMed
  6.  
    1. Schweitzer E.J., Wilson J., Jacobs S., Machan C.H., Philosophe B., Farney A. Increased rates of donation with laparoscopic donor nephrectomy. Ann Surg. 2000;232:392–400. - PMC - PubMed
  7.  
    1. Kuo P.C., Johnson L.B. Laparoscopic donor nephrectomy increases the supply of living donor kidneys: a center-specific microeconomic analysis. Transplantation. 2000;69:2211–2213. - PubMed
  8.  
    1. Ratner L.E., Kavoussi L.R., Sroka M., Hiller J., Weber R., Schulam P.G. Laparoscopic assisted live donor nephrectomy – a comparison with the open approach. Transplantation. 1997;63:229–233. - PubMed
  9.  
    1. Nogueira J.M., Cangro C.B., Fink J.C., Schweitzer E., Wiland A., Klassen D.K. A comparison of recipient renal outcomes with laparoscopic versus open live donor nephrectomy. Transplantation. 1999;67:722–728. - PubMed
  10.  
    1. Novick A.C. Laparoscopic live donor nephrectomy: con. Urology. 1999;53:668–670. - PubMed
  11.  
    1. Barry J.M. Laparoscopic donor nephrectomy. Con Transplantation. 2000;70:1546–1548. - PubMed
  12.  
    1. Ratner L.E., Fabrizio M., Chavin K., Montgomery R.A., Mandal A.K., Kavoussi L.R. Technical considerations in the delivery of the kidney during laparoscopic live-donor nephrectomy. J Am Coll Surg. 1999;189:427–430. - PubMed
  13.  
    1. Montgomery R.A., Kavoussi L.R., Su L., Sinkov V., Cohen C., Maley W.R. Improved recipient results after 5 years of performing laparoscopic donor nephrectomy. Transpl Proc. 2001;33:1108–1110. - PubMed
  14.  
    1. Khauli R.B., Hussein M., Madi R., Shaar A., Dagher F.J. Technical modifications of laparoscopic donor nephrectomy associated with improved graft quality and transplant outcome. Transpl Proc. 2003;35:2551. - PubMed
  15.  
    1. Khauli R.B., El-Hout Y., Hussein M. Technical modifications of laparoscopic donor nephrectomy; improved results with refinements in technique that mimic open nephrectomy. Transpl Proc. 2005;37:625–636. - PubMed
  16.  
    1. Khauli R.B., Hussein M., Hijaz A., Wazzan W. Laparoscopic donor nephrectomy: overcoming the learning curve. Transpl Proc. 2001;33:2673–2674. - PubMed
  17.  
    1. Kaçar S., Gürkan C., Karaca C., Varilsüha M., Karaoglan M., Akman F. Open versus laparoscopic donor nephrectomy in live related renal transplantation. Transpl Proc. 2004;36:2620–2622. - PubMed
  18.  
    1. Gürkan A., Kaçar S., Basak C., Varilsüha M., Karaca C. Do multiple renal arteries restrict laparoscopic donor nephrectomy? Transpl Proc. 2004;36:105–107. - PubMed
  19.  
    1. Simforoosh N., Basiri A., Tabibi A., Shakhssalim N., Hosseini Moghaddam S.M.M. Comparison of laparoscopic and open donor nephrectomy: a randomized controlled trial. BJU Int. 2005;95:851–855. - PubMed
  20.  
    1. Fettouh H.A., Raouf H.A., Shenoufy A.E.I., Feel A., Agabo H., Hakim A.A. Laparoscopic donor nephrectomy: single-center experience in Egypt with 400 consecutive cases. Transpl Proc. 2007;39:807–810. - PubMed
  21.  
    1. Buresley S., Samhan M., Al-Mousawi M. Kuwait experience in laparoscopic donor nephrectomy. The first 80 cases. Transpl Proc. 2007;39:813–815. - PubMed
  22.  
    1. Genc V., Ozgencil E., Orozakunov E., Can O.S., Yilmaz A.A., Ozsay O. Pure laparoscopic versus open live donor nephrectomy. Evaluation of health survey and graft functions. Transpl Proc. 2011;43:791–794. - PubMed
  23.  
    1. Nikeghbalian S., Kazemi K., Salehipour M., Roozbeh J., Sagheb M.M., Kakaei F. Transperitoneal laparoscopic living donor nephrectomy: 2 years’ experience. Transpl Proc. 2009;41:2729–2730. - PubMed
  24.  
    1. Simforoosh N., Basiri A., Tabibi A., Shakhssalim N. Laparoscopic donor nephrectomy – an Iranian model for development countries: a cost-effective no-rush approach. Exp Clin Transplant. 2004;2:249–253. - PubMed
  25.  
    1. Khauli R.B., El-Hout Y., Hussein M., Dagher F.J., Medawar W., Houjaij A. A controlled sequential evaluation of open donor nephrectomy versus classical and modified laparoscopic donor nephrectomy: an update. Transpl Proc. 2005;37:2944–2946. - PubMed
  26.  
    1. Bachir B.G., Hussein M., Nasr R., Abu-Dargham R., Khauli R.B. Evaluation of right versus left laparoscopic donor nephrectomy. Exp Clin Transplant. 2011;9:310–314. - PubMed
  27.  
    1. Genc V., Orozakunov E., Ozgencil E., Can O.S., Yilmaz A.A., Cipe G. Single stapler technique laparoscopic donor nephrectomy. Transpl Proc. 2011;43:787–790. - PubMed
  28.  
    1. Suzuki K., Ushiyama T., Ishikawa A., Mugiya S., Fujita K. Retroperitoneoscopy assisted live donor nephrectomy: the initial 2 cases. J Urol. 1997;158:1353–1356. - PubMed
  29.  
    1. Moosa M. Renal transplantation in developing countries. In: Morris P., Knechtle S., editors. Kidney Transplantation. Principles and Practice. 6th ed. Saunders; USA: 2008. pp. 630–656.
  30.  
    1. Khauli R.B., Hussein M., Shaar A., Madi R., Medawar W., Habbal A. A prospective evaluation of laparoscopic donor nephrectomy versus open donor nephrectomy. Transpl Proc. 2003;35:2552. - PubMed
  31.  
    1. Mandal A.K., Cohen C., Montgomery R.A., Kavoussi L.R., Ratner L.E. Should the indications for laparoscopic live donor nephrectomy of the right kidney be the same as for the open procedure? Anomalous left renal vasculature is not a contraindication to laparoscopic left donor nephrectomy. Transplantation. 2001;71:660–664. - PubMed
  32.  
    1. Su L.M., Ratner L.E., Montgomery R.A., Jarrett T.W., Trock B.J., Sinkov V. Laparoscopic live donor nephrectomy trends in donor and recipient morbidity following 381 consecutive cases. Ann Surg. 2004;240:358–363. - PMC - PubMed
  33.  
    1. Jacobs S.C., Cho E., Dunkin B.J., Flowers J.L., Schweitzer E., Cangro C. Laparoscopic live donor nephrectomy. The University of Maryland 3-year experience. J Urol. 2000;164:1494–1499. - PubMed
  34.  
    1. Breda A., Veale J., Liao J., Schulam P.G. Complications of laparoscopic living donor nephrectomy and their management. The UCLA experience. Urology. 2007;69:49–52. - PubMed
  35.  
    1. Leventhal J., Kocak B., Salvalaggio P.R.O., Koffron A.J., Baker T.B., Kaufman D.B. Laparoscopic donor nephrectomy1997–2003: Lessons learned with 500 cases at a single institution. Surgery. 2004;136:881–890. - PubMed
  36.  
    1. Ng C.S., Abreu S.C., Abou El-Fettouh H.I., Kaouk J.H., Desai M.M., Goldfarb D.A. Right retroperitoneal versus left transperitoneal laparoscopic live donor nephrectomy. Urology. 2004;63:857–861. - PubMed
  37.  
    1. Jacobs S.C., Cho E., Foster C., Liao P., Bartlett S.T. Laparoscopic donor nephrectomy. The University of Maryland 6-year experience. J Urol. 2004;171:47–51. - PubMed
  38.  
    1. Harper J.D., Breda A., Leppert J.T., Veale J.L., Gritschand H.A., Schulam P.G. Experience with 750 consecutive laparoscopic donor nephrectomies — is it time to use a standardized classification of complications? J Urol. 2010;183:1941–1946. - PubMed
  39.  
    1. Editorial. Participants in the International Summit on Transplant Tourism and Organ Trafficking convened by The Transplantation Society and International Society of Nephrology in Istanbul, Turkey, 30 April to 2 May 2008. The Declaration of Istanbul on Organ Trafficking and Transplant Tourism. Nephrol Dial Transplant 2008;86:1013–8. - PubMed