Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death
Kannan Badri Narayanan 1, Manaf Ali 2, Barry J Barclay 3, Qiang Shawn Cheng 4, Leandro D'Abronzo 5, Rita Dornetshuber-Fleiss 6, Paramita M Ghosh 5, Michael J Gonzalez Guzman 7, Tae-Jin Lee 8, Po Sing Leung 9, Lin Li 9, Suidjit Luanpitpong 10, Edward Ratovitski 11, Yon Rojanasakul 12, Maria Fiammetta Romano 13, Simona Romano 13, Ranjeet K Sinha 14, Clement Yedjou 15, Fahd Al-Mulla 16, Rabeah Al-Temaimi 16, Amedeo Amedei 17, Dustin G Brown 18, Elizabeth P Ryan 18, Annamaria Colacci 19, Roslida A Hamid 20, Chiara Mondello 21, Jayadev Raju 22, Hosni K Salem 23, Jordan Woodrick 24, A Ivana Scovassi 21, Neetu Singh 25, Monica Vaccari 19, Rabindra Roy 24, Stefano Forte 26, Lorenzo Memeo 26, Seo Yun Kim 27, William H Bisson 28, Leroy Lowe 29, Hyun Ho Park 1
Affiliations
Affiliations
- 1Department of Chemistry and Biochemistry, Yeungnam University, Gyeongsan 712-749, South Korea, Sultan Zainal Abidin University, Malaysia, Plant Biotechnologies Inc, St. Albert AB, Canada, Computer Science Department, Southern Illinois University, Carbondale, IL 62901, USA, Department of Urology, University of California Davis, Sacramento, CA 95817, USA, Department of Pharmacology and Toxicology, University of Vienna, Austria, University of Puerto Rico, Medical Sciences Campus, School of Public Health, Nutrition Program, San Juan Puerto Rico 00936-5067, USA, Department of Anatomy, College of Medicine, Yeungnam University, Daegu, 705-717, South Korea, School of Biomedical Science, The Chinese University Of Hong Kong, Hong Kong, China, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand, Department of Otolaryngology/Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA, Department of Pharmaceutical Sciences, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA, Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy, Department of Molecular and Experimental Medicine, MEM 180, The Scripps Research Institute, La Jolla, CA 92037, USA, Department of Biology, Jackson State University, Jackson, MS 39217, USA, Department of Pathology, Kuwait University, Safat 13110, Kuwait, Department of Experimental and Clinical Medicine, University of Firenze, Firenze, 50134, Italy, Department of Environmental and Radiological Health Sciences, Colorado state University/ Colorado School of Public Health, Fort Collins, CO 80523-1680, USA, Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna, 40126, Italy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Se
- 2Sultan Zainal Abidin University, Malaysia.
- 3Plant Biotechnologies Inc, St. Albert AB, Canada.
- 4Computer Science Department, Southern Illinois University, Carbondale, IL 62901, USA.
- 5Department of Urology, University of California Davis, Sacramento, CA 95817, USA.
- 6Department of Pharmacology and Toxicology, University of Vienna, Austria.
- 7University of Puerto Rico, Medical Sciences Campus, School of Public Health, Nutrition Program, San Juan Puerto Rico 00936-5067, USA.
- 8Department of Anatomy, College of Medicine, Yeungnam University, Daegu, 705-717, South Korea.
- 9School of Biomedical Science, The Chinese University Of Hong Kong, Hong Kong, China.
- 10Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
- 11Department of Otolaryngology/Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
- 12Department of Pharmaceutical Sciences, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA.
- 13Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy.
- 14Department of Molecular and Experimental Medicine, MEM 180, The Scripps Research Institute, La Jolla, CA 92037, USA.
- 15Department of Biology, Jackson State University, Jackson, MS 39217, USA.
- 16Department of Pathology, Kuwait University, Safat 13110, Kuwait.
- 17Department of Experimental and Clinical Medicine, University of Firenze, Firenze, 50134, Italy.
- 18Department of Environmental and Radiological Health Sciences, Colorado state University/ Colorado School of Public Health, Fort Collins, CO 80523-1680, USA.
- 19Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna, 40126, Italy.
- 20Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia.
- 21Institute of Molecular Genetics, National Research Council, Pavia, 27100, Italy.
- 22Toxicology Research Division, Bureau of Chemical Safety Food Directorate, Health Products and Food Branch Health Canada, Ottawa, Ontario, K1A0K9, Canada.
- 23Urology Department, Kasr Al-Ainy School of Medicine, Cairo University, El Manial, Cairo, 12515, Egypt.
- 24Molecular Oncology Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC, 20057, USA.
- 25Advenced Molecular Science Research Centre, King George's Medical University, Lucknow, Uttar Pradesh, 226003, India.
- 26Mediterranean Institute of Oncology, Viagrande, 95029, Italy.
- 27Department of Internal Medicine, Korea Cancer Center Hospital, Seoul 139-706, South Korea.
- 28Environmental and Molecular Toxicology, Environmental Health Science Center, Oregon State University, Corvallis, OR 97331, USA and.
- 29Getting to Know Cancer, Truro, Nova Scotia, Canada.
Abstract
Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically, the up-regulation of pro-survival factors, including oncogenic factors and antiapoptotic signaling pathways, and the down-regulation of pro-apoptotic factors, including tumor suppressive factors, confers resistance to cell death in tumor cells, which supports the emergence of a fully immortalized cellular phenotype. This review considers the potential relevance of ubiquitous environmental chemical exposures that have been shown to disrupt key pathways and mechanisms associated with this sort of dysfunction. Specifically, bisphenol A, chlorothalonil, dibutyl phthalate, dichlorvos, lindane, linuron, methoxychlor and oxyfluorfen are discussed as prototypical chemical disruptors; as their effects relate to resistance to cell death, as constituents within environmental mixtures and as potential contributors to environmental carcinogenesis.
Similar articles
Hu Z, Brooks SA, Dormoy V, Hsu CW, Hsu HY, Lin LT, Massfelder T, Rathmell WK, Xia M, Al-Mulla F, Al-Temaimi R, Amedei A, Brown DG, Prudhomme KR, Colacci A, Hamid RA, Mondello C, Raju J, Ryan EP, Woodrick J, Scovassi AI, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Salem HK, Lowe L, Jensen L, Bisson WH, Kleinstreuer N.Carcinogenesis. 2015 Jun;36 Suppl 1(Suppl 1):S184-202. doi: 10.1093/carcin/bgv036.PMID: 26106137 Free PMC article. Review.
Goodson WH 3rd, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu CW, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon EY, Laconi E, Marongiu F, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams G, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu HY, Park HH, Koturbash I, Miousse IR, Scovassi AI, Klaunig JE, Vondráček J, Raju J, Roman J, Wise JP Sr, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen-Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L, D'Abronzo LS, Lin LT, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez MJ, Karamouzis …See abstract for full author list ➔Carcinogenesis. 2015 Jun;36 Suppl 1(Suppl 1):S254-96. doi: 10.1093/carcin/bgv039.PMID: 26106142 Free PMC article. Review.
Causes of genome instability: the effect of low dose chemical exposures in modern society.
Langie SA, Koppen G, Desaulniers D, Al-Mulla F, Al-Temaimi R, Amedei A, Azqueta A, Bisson WH, Brown DG, Brunborg G, Charles AK, Chen T, Colacci A, Darroudi F, Forte S, Gonzalez L, Hamid RA, Knudsen LE, Leyns L, Lopez de Cerain Salsamendi A, Memeo L, Mondello C, Mothersill C, Olsen AK, Pavanello S, Raju J, Rojas E, Roy R, Ryan EP, Ostrosky-Wegman P, Salem HK, Scovassi AI, Singh N, Vaccari M, Van Schooten FJ, Valverde M, Woodrick J, Zhang L, van Larebeke N, Kirsch-Volders M, Collins AR.Carcinogenesis. 2015 Jun;36 Suppl 1(Suppl 1):S61-88. doi: 10.1093/carcin/bgv031.PMID: 26106144 Free PMC article. Review.
Environmental immune disruptors, inflammation and cancer risk.
Thompson PA, Khatami M, Baglole CJ, Sun J, Harris SA, Moon EY, Al-Mulla F, Al-Temaimi R, Brown DG, Colacci A, Mondello C, Raju J, Ryan EP, Woodrick J, Scovassi AI, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Salem HK, Amedei A, Hamid RA, Lowe L, Guarnieri T, Bisson WH.Carcinogenesis. 2015 Jun;36 Suppl 1(Suppl 1):S232-53. doi: 10.1093/carcin/bgv038.PMID: 26106141 Free PMC article. Review.
Engström W, Darbre P, Eriksson S, Gulliver L, Hultman T, Karamouzis MV, Klaunig JE, Mehta R, Moorwood K, Sanderson T, Sone H, Vadgama P, Wagemaker G, Ward A, Singh N, Al-Mulla F, Al-Temaimi R, Amedei A, Colacci AM, Vaccari M, Mondello C, Scovassi AI, Raju J, Hamid RA, Memeo L, Forte S, Roy R, Woodrick J, Salem HK, Ryan EP, Brown DG, Bisson WH.Carcinogenesis. 2015 Jun;36 Suppl 1(Suppl 1):S38-60. doi: 10.1093/carcin/bgv030.PMID: 26106143 Free PMC article. Review.
Cited by
Cell cycle exits and U-turns: Quiescence as multiple reversible forms of arrest.
Johnson MS, Cook JG.Fac Rev. 2023 Mar 8;12:5. doi: 10.12703/r/12-5. eCollection 2023.PMID: 36923701 Free PMC article. Review.
Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases.
Yao Q, Zhang X, Chen D.Front Oncol. 2022 Feb 25;12:848296. doi: 10.3389/fonc.2022.848296. eCollection 2022.PMID: 35280790 Free PMC article. Review.
Anderson FL, von Herrmann KM, Young AL, Havrda MC.Toxicol Sci. 2021 Sep 28;183(2):378-392. doi: 10.1093/toxsci/kfab090.PMID: 34289071 Free PMC article.
Liang PI, Wang CC, Cheng HJ, Wang SS, Lin YC, Lin P, Tung CW.Database (Oxford). 2020 Jan 1;2020:baaa045. doi: 10.1093/database/baaa045.PMID: 32539087 Free PMC article.
The Analysis of Bifenox and Dichlobenil Toxicity in Selected Microorganisms and Human Cancer Cells.
Jabłońska-Trypuć A, Wydro U, Serra-Majem L, Wołejko E, Butarewicz A.Int J Environ Res Public Health. 2019 Oct 27;16(21):4137. doi: 10.3390/ijerph16214137.PMID: 31717849 Free PMC article.