Therapeutic use of melatonin in schizophrenia-more than meets the eye!

Ahmed Naguy 1

Affiliations

19 March 2022

-

doi: 10.5498/wjp.v12.i3.533

Abstract

Adjunctive melatonin use in schizophrenia, as supported by a modicum of evidence, has multiple transcending chronobiotic actions, including fixing concurrent sleep problems to bona fide augmentative antipsychotic actions, mitigating the risk of tardive dyskinesias, curbing the drastic metabolic syndrome and ultimately providing neuroprotective actions. Its use is rather an art than science!

Keywords: Antipsychotic; Chronobiotic; Melatonin; Metabolic syndrome; Neuroprotectant; Schizophrenia; Tardive dyskinesia.

Conflict of interest statement

Conflict-of-interest statement: Author declares no conflicts of interest or financial affiliations.

Similar articles

Therapeutic use of melatonin in schizophrenia: A systematic review.

Duan C, Jenkins ZM, Castle D.World J Psychiatry. 2021 Aug 19;11(8):463-476. doi: 10.5498/wjp.v11.i8.463. eCollection 2021 Aug 19.PMID: 34513608 Free PMC article.

Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects.

Anderson G, Maes M.Metab Brain Dis. 2012 Jun;27(2):113-9. doi: 10.1007/s11011-012-9307-9. Epub 2012 Apr 25.PMID: 22527998 Review.

Is melatonin treatment effective for tardive dyskinesia?

Shamir E, Barak Y, Plopsky I, Zisapel N, Elizur A, Weizman A.J Clin Psychiatry. 2000 Aug;61(8):556-8. doi: 10.4088/jcp.v61n0803.PMID: 10982197 Clinical Trial.

CYP2D6 polymorphisms and the risk of tardive dyskinesia in schizophrenia: a meta-analysis.

Patsopoulos NA, Ntzani EE, Zintzaras E, Ioannidis JP.Pharmacogenet Genomics. 2005 Mar;15(3):151-8. doi: 10.1097/01213011-200503000-00003.PMID: 15861039

Anticholinergic medication for antipsychotic-induced tardive dyskinesia.

Bergman H, Soares-Weiser K.Cochrane Database Syst Rev. 2018 Jan 17;1(1):CD000204. doi: 10.1002/14651858.CD000204.pub2.PMID: 29341071 Free PMC article. Review.

KMEL References

https://pubmed.ncbi.nlm.nih.gov/

References

  1.  
    1. Duan C, Jenkins ZM, Castle D. Therapeutic use of melatonin in schizophrenia: A systematic review. World J Psychiatry. 2021;11:463–476. - PMC - PubMed
  2.  
    1. Naguy A, Francis K. Melatonin: A new game-changer in juvenile bipolar disorders? Psychiatry Res. 2019;279:364–365. - PubMed
  3.  
    1. Delorme TC, Srivastava LK, Cermakian N. Are Circadian Disturbances a Core Pathophysiological Component of Schizophrenia? J Biol Rhythms. 2020;35:325–339. - PubMed
  4.  
    1. Naguy A, Al-Amiri B, Shoukry T. Melatonin Use in Psychiatry-Quo Vadis? Am J Ther. 2020;27:e495–e499. - PubMed
  5.  
    1. Naguy A, Moodliar-Rensburg S, Alamiri B. The long-acting injectable atypical antipsychotics-merits and demerits! CNS Spectr. 2021;26:442–443. - PubMed

Page Navigation