Systemic Solutions for Addressing Non-Communicable Diseases in Low- and Middle-Income Countries
Aakash Ganju 1, Alessandra C Goulart 2, Amrit Ray 3, Anurita Majumdar 4, Barrett W Jeffers 3, Gloria Llamosa 5, Henry Cañizares 6, Ianne Jireh Ramos-Cañizares 6, Ibtihal Fadhil 7, Kannan Subramaniam 8, Lee-Ling Lim 9, Luna El Bizri 10, M Ramesh 11, Mathew Guilford 12, Raghib Ali 13, Ratna Duddi Devi 14 15, Rayaz A Malik 16, Shekhar Potkar 17, Yuan-Pang Wang 18
Affiliations
Affiliations
- Executive Office, Saathealth, Mumbai, India.
- Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, São Paulo, Brazil.
- Research, Development and Medical, Upjohn - a Pfizer Division, New York, NY, USA.
- Research, Development and Medical, Emerging Markets, Upjohn - a Pfizer Division, Singapore.
- Mexican Neurology and Psychiatry Society, Mexico City, Mexico.
- Vicente Sotto Memorial Medical Center, Cebu City, Philippines.
- Eastern Mediterranean NCD Alliance, Kuwait City, Kuwait.
- Research, Development and Medical, Upjohn - a Pfizer Division, Sydney, Australia.
- Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
- School of Pharmacy, Lebanese University, Hadath, Lebanon.
- Lee Kuan Yew School of Public Policy, National University of Singapore, Singapore.
- Executive Office, Common Health, Kuala Lumpur, Malaysia.
- Public Health Research Center, New York University, Abu Dhabi, United Arab Emirates.
- Executive Office, DakshamA Health and Education, Gurgaon, India.
- Board of Directors, International Alliance of Patient Organizations, London, England.
- Weill Cornell Medicine, Doha, Qatar.
- Research, Development and Medical, Upjohn - a Pfizer Division, Dubai, United Arab Emirates.
- Instituto de Psiquiatria (LIM-23), Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Abstract
Non-communicable diseases (NCDs) have been on the rise in low- and middle-income countries (LMICs) over the last few decades and represent a significant healthcare concern. Over 85% of "premature" deaths worldwide due to NCDs occur in the LMICs. NCDs are an economic burden on these countries, increasing their healthcare expenditure. However, targeting NCDs in LMICs is challenging due to evolving health systems and an emphasis on acute illness. The major issues include limitations with universal health coverage, regulations, funding, distribution and availability of the healthcare workforce, and availability of health data. Experts from across the health sector in LMICs formed a Think Tank to understand and examine the issues, and to offer potential opportunities that may address the rising burden of NCDs in these countries. This review presents the evidence and posits pragmatic solutions to combat NCDs.
Keywords: low- and middle-income countries; multisectoral; non-communicable diseases; public–private partnership; universal health coverage.
Conflict of interest statement
This article is based on the dialogue that occurred at the “Expert Forum on NCDs in Emerging Nations” convened by Pfizer in Dubai, UAE, 27–28 September 2019 and attended by all authors. Honoraria were provided by Pfizer to the external experts for their attendance at the meeting No author received an honorarium for the preparation of the article. Dr Amrit Ray, Dr Anurita Majumdar, Dr Barrett W Jeffers, Dr Kannan Subramaniam and Dr Shekhar Potkar are employees of Pfizer. The authors report no other conflicts of interest in this work. The views and opinions expressed in this article are those of the authors and do not represent or reflect in any way the official policy or position of their current or previous employers. Editorial and medical writing support was provided by Transform Medical Communications, which was funded by Pfizer. Mr Mathew Guilford reports personal fees from Common Health, Inc., during the conduct of the study; personal fees from Pfizer Upjohn, outside the submitted work. Dr Raghib Ali reports personal fees from Pfizer Upjohn, grants from Pfizer Upjohn, outside the submitted work. Dr Rayaz A Malik has attended advisory board to discuss NCD’s by pfizer, during the conduct of the study; and received grants from Pfizer, grants to support a consensus meeting on neurodegenerative disease from Biogen, personal fees from Novo Nordisk, personal fees from Aventis, outside the submitted work.
Figures
Similar articles
Essue BM, Laba M., Knaul F, Chu A, Minh HV, Nguyen TKP, Jan S.In: Jamison DT, Gelband H, Horton S, Jha P, Laxminarayan R, Mock CN, Nugent R, editors. Disease Control Priorities: Improving Health and Reducing Poverty. 3rd edition. Washington (DC): The International Bank for Reconstruction and Development / The World Bank; 2017 Nov 27. Chapter 6.PMID: 30212160 Free Books & Documents. Review.
Non-communicable diseases and health systems reform in low-and-middle-income countries.
Robinson HM, Hort K.Pac Health Dialog. 2012 Apr;18(1):179-90.PMID: 23240355
Feroz A, Kadir MM, Saleem S.Glob Health Action. 2018;11(1):1496887. doi: 10.1080/16549716.2018.1496887.PMID: 30040605 Free PMC article.
The household economic burden of non-communicable diseases in 18 countries.
Murphy A, Palafox B, Walli-Attaei M, Powell-Jackson T, Rangarajan S, Alhabib KF, Avezum AJ, Calik KBT, Chifamba J, Choudhury T, Dagenais G, Dans AL, Gupta R, Iqbal R, Kaur M, Kelishadi R, Khatib R, Kruger IM, Kutty VR, Lear SA, Li W, Lopez-Jaramillo P, Mohan V, Mony PK, Orlandini A, Rosengren A, Rosnah I, Seron P, Teo K, Tse LA, Tsolekile L, Wang Y, Wielgosz A, Yan R, Yeates KE, Yusoff K, Zatonska K, Hanson K, Yusuf S, McKee M.BMJ Glob Health. 2020 Feb 11;5(2):e002040. doi: 10.1136/bmjgh-2019-002040. eCollection 2020.PMID: 32133191 Free PMC article.
Haque M, Islam T, Rahman NAA, McKimm J, Abdullah A, Dhingra S.Risk Manag Healthc Policy. 2020 May 18;13:409-426. doi: 10.2147/RMHP.S239074. eCollection 2020.PMID: 32547272 Free PMC article. Review.
Cited by
Alani AH, Miller L, Darji B, Waweru I, Atwiine AB, Tonelli M, Mogga JLK, Adams A, Ndinda L, Jongo S, Kiapi L.Confl Health. 2023 Jun 5;17(1):27. doi: 10.1186/s13031-023-00525-w.PMID: 37277827 Free PMC article.
Marshall K, Beaden P, Durrani H, Tang K, Mogilevskii R, Bhutta Z.Int J Qual Stud Health Well-being. 2023 Dec;18(1):2156099. doi: 10.1080/17482631.2022.2156099.PMID: 36591948 Free PMC article. Review.
Rossouw L, Filby S.PLoS One. 2022 Nov 22;17(11):e0277702. doi: 10.1371/journal.pone.0277702. eCollection 2022.PMID: 36413527 Free PMC article.
Research protocol for impact assessment of a project to scale up food policies in the Pacific.
Patay D, Trieu K, McKenzie B, Ramanathan S, Hure A, Bell C, Thow AM, Allender S, Reeve E, Palu A, Woodward M, Waqa G, Webster J.Health Res Policy Syst. 2022 Oct 29;20(1):117. doi: 10.1186/s12961-022-00927-x.PMID: 36309749 Free PMC article.
Ross S, Chadha K, Mishra S, Lewington S, Shepperd S, Gathani T; NCDRI study collaborators.BMC Public Health. 2022 Aug 12;22(1):1538. doi: 10.1186/s12889-022-13818-1.PMID: 35962330 Free PMC article.
KMEL References
References
-
- Non communicable diseases [homepage on the internet]. World Health Organization. Available from: https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases. Accessed February17, 2020.
-
- The Global Economic Burden of Non-communicable Diseases [homepage on the internet]. Geneva: World Economic Forum. World Economic Forum. Available from: http://www3.weforum.org/docs/WEF_Harvard_HE_GlobalEconomicBurdenNonCommu.... Accessed February17, 2020.
-
- Guidance note on the integration of noncommunicable diseases into the united nations development assistance framework [homepage on the internet]. World Health Organisation. Available from: https://www.who.int/nmh/ncd-task-force/guidance-note.pdf. Accessed October28, 2019.
-
- Mental Health and Neurological Disorders [homepage on the internet] NCD Alliance. Available from: https://ncdalliance.org/why-ncds/ncd-management/mental-health-and-neurol.... Accessed February17, 2020.
-
- NCD countdown 2030 [homepage on internet]. Available from: http://www.ncdcountdown.org/. Accessed October30, 2019.
-
- What legislators need to know [homepage on the internet]. World Health Organisation. Available from: https://www.undp.org/content/dam/undp/library/HIV-AIDS/NCDs/Legislators%.... Accessed February17, 2020.
-
- Outcome document of the High-Level Meeting of the General Assembly on the Comprehensive Review and Assessment of the Progress Achieved in the Prevention and Control of Non-communicable Diseases [homepage on the internet]. UN General Assembly; 2014. Available from: http://digitallibrary.un.org/record/774662/files/A_68_L.53-EN.pdf. Accessed May26, 2020.
-
- Leading the Conversation on Noncommunicable Diseases Worldwide: an Evidence-Based Review of Key Research and Strategies to Develop Sustainable Solutions [homepage on internet]. Pfizer Upjohn. Available from: https://www.pfizer.com/upjohn_ncd_white_paper. Accessed May26, 2020.
-
- Horton R. Offline: chronic diseases—the social justice issue of our time. Lancet. 2015;386(10011):2378. doi:10.1016/S0140-6736(15)01178-2 - DOI
-
- Political Declaration of the High-level Meeting on Universal Health Coverage [homepage on the internet]. Available from: https://www.un.org/pga/73/wp-content/uploads/sites/53/2019/07/FINAL-draf.... Accessed February17, 2020.
-
- Wu F, Guo Y, Chatterji S, et al. Common risk factors for chronic non-communicable diseases among older adults in China, Ghana, Mexico, India, Russia and South Africa: the study on global AGEing and adult health (SAGE) wave 1. BMC Public Health. 2015;15(1):88. doi:10.1186/s12889-015-1407-0 - DOI - PMC - PubMed
-
- Doll R, Peto R, Boreham J, Sutherland I. Mortality in relation to smoking: 50 years’ observations on male British doctors. BMJ. 2004;328(7455):1519. doi:10.1136/bmj.38142.554479.AE - DOI - PMC - PubMed
-
- Value-based healthcare: A global assessment [homepage on the internet]. Economist Intelligence Unit. Available from: https://perspectives.eiu.com/sites/default/files/EIU_Medtronic_Findings-.... Accessed February17, 2020.
-
- Health outcomes and cost: A 166-country comparison [homepage on the internet]. Economist Intelligence Unit. Available from: https://www.eiu.com/public/topical_report.aspx?campaignid=Healthoutcome2014. Accessed October30, 2019.
-
- Adair T. Progress towards reducing premature NCD mortality - The Lancet Global Health. Lancet. 2018;6(12):E1254–E1255. - PubMed
-
- 2018 United Nations High-Level Meeting on Non-communicable Diseases [homepage on the internet]. ESMO. Available from: https://www.esmo.org/policy/world-health-organization-united-nations/uni.... Accessed May26, 2020.
-
- Know the NCD targets [homepage on the internet]. World Health Organization. Available from: https://www.who.int/beat-ncds/take-action/targets/en/. Accessed February17, 2020.
-
- UN High-Level Meeting on universal health coverage [homepage on the internet]. World Health Organisation. Available from: https://www.who.int/news-room/events/detail/2019/09/23/default-calendar/.... Accessed October28, 2019.
-
- Universal health coverage (UHC) [homepage on the internet]. World Health Organisation. Available from: https://www.who.int/news-room/fact-sheets/detail/universal-health-covera...). Accessed February17, 2020.
-
- Noncommunicable diseases and mental health: south East Asian Region [homepage on the internet]. World Health Organisation. Available from: https://www.who.int/nmh/ncd-tools/who-regions-south-east-asia/en/. Accessed October25, 2019.
-
- Myint CY, Pavlova M, Thein KN, Groot W. A systematic review of the health-financing mechanisms in the Association of Southeast Asian Nations countries and the People’s Republic of China: lessons for the move towards universal health coverage. PLoS One. 2019;14(6):e0217278. doi:10.1371/journal.pone.0217278 - DOI - PMC - PubMed
-
- Joint Annual Health Review 2016 [homepage on the internet]. Vietnam Ministry of Health. Available from: http://jahr.org.vn/downloads/JAHR2016/JAHR2016_Edraft.pdf. Accessed February17, 2020.
-
- Tackling NCDs: best buys [homepage on the internet]. World Health Organisation. Available from: https://apps.who.int/iris/bitstream/handle/10665/259232/WHO-NMH-NVI-17.9.... Accessed February17, 2020.
-
- From Burden to “Best Buys”: reducing the Economic Impact of Non-Communicable Diseases in Low- and Middle-Income Countries [homepage on the internet]. World Health Organisation. Available from: https://www.who.int/nmh/publications/best_buys_summary.pdf. Accessed February17, 2020.
-
- Lebanon: needs assessment mission [homepage on the internet]. World Health Organisation. Available from: http://www.who.int/fctc/implementation/needs/factsheet-na-fctc-lebanon.pdf. Accessed February17, 2020.
-
- Ambient air pollution [homepage on the internet]. World Health Organisation. Available from: https://www.who.int/gho/phe/outdoor_air_pollution/en/. Accessed February17, 2020.
-
- Workforce Resources for Health in Developing Countries [homepage on the internet]. World Health Organisation. Available from: https://www.who.int/workforcealliance/media/KeyMessages_3GF.pdf. Accessed October25, 2019.
-
- Bangdiwala SI, Fonn S, Okoye O, Tollman S. Workforce resources for health in developing countries. Public Health Rev. 2010;32(1):296–318. doi:10.1007/BF03391604 - DOI
-
- CSEM reflections on UHC global monitoring report [homepage on the internet]. Available from: https://www.uhc2030.org/fileadmin/uploads/uhc2030/Documents/Key_Issues/U.... Accessed February17, 2020.
-
- Expert group meeting on the science‐policy interface summary [homepage on the internet]. Available from: https://sustainabledevelopment.un.org/content/documents/2075Summary%20of.... Accessed November6, 2019.
-
- Approaches to establishing country-level multisectoral coordination mechanisms for the prevention and control of noncommunicable diseases [homepage on the internet]. World Health Organisation. Available from: http://www.searo.who.int/entity/noncommunicable_diseases/documents/ncd-m.... Accessed October30, 2019.
-
- CDC’s Vision for Public Health Surveillance in the 21st Century [homepage on the internet]. Centers for Disease Control. Available from: https://www.cdc.gov/mmwr/pdf/other/su6103.pdf. Accessed October25, 2019.
-
- Findings from the Global Burden of Disease Study [homepage on the internet]. Institute for Health Metrics and Evaluation (IHME). Available from: http://www.healthdata.org/sites/default/files/files/policy_report/2019/G.... Accessed October 30, 2019.
-
- IDF Diabetes Atlas 9th edition 2019 [homepage on the internet]. International Diabetes Federation. Available from: https://www.diabetesatlas.org/en/. Accessed February17, 2020.
-
- Sharma A. Global research priorities for noncommunicable diseases prevention, management, and control. Int J Non-Commun Dis. 2017;2:107–112.
-
- WHO/ISH Cardiovascular Risk Prediction Charts Strengths and Limitations [homepage on the internet]. World Health Organisation. Available from: https://www.who.int/cardiovascular_diseases/publications/cvd_qa.pdf. Accessed February17, 2020.
-
- STEPS: A framework for surveillance [homepage on the internet]. World Health Organisation. Available from: https://www.who.int/ncd_surveillance/en/steps_framework_dec03.pdf. Accessed October25, 2019.
-
- Ramos-Cañizares IJ. E-Sakto: lowering the cardiovascular risk of patients with hypertension and diabetes through public–private partnership. KnE Social Sci. 2018;3(6):578. doi:10.18502/kss.v3i6.2406 - DOI
-
- Beating non-communicable diseases in the community: the contribution of pharmacists [homepage on the internet]. International Pharmaceutical Federation. Available from: https://www.fip.org/files/content/publications/2019/beating-ncds-in-the-.... Accessed November8, 2019.
-
- Bizri LE The role of the community pharmacists in non-communicable diseases: it is time for change. Proceedings of the 26th Annual Congress of Lebanese Order of Pharmacists; November 16–18, 2018; Beirut, Lebanon.
-
- Primary Health Care Systems (PRIMASYS): comprehensive case study from Lebanon [homepage on the internet]. World Health Organisation. Available from: http://www.who.int/alliance-hpsr/projects/AHPSR-PRIMASYS-Lebanon-compreh.... Accessed February17, 2020.
-
- “Sin Tax” expands health coverage in the Philippines [homepage on the internet]. World Health Organisation. Available from: https://www.who.int/features/2015/ncd-philippines/en/. Accessed November6, 2019.
-
- Follow-up to the high-level meetings of the United Nations General Assembly on health-related issues [homepage on the internet]. World Health Organisation. Available from: https://apps.who.int/iris/handle/10665/327434. Accessed October29, 2019.
-
- Tools for implementing WHO PEN [homepage on the internet]. World Health Organisation. Available from: who.int/ncds/management/pen_tools/en/. Accessed October27, 2019.
-
- Chang AY, Cowling K, Micah AE, et al. Past, present, and future of global health financing: a review of development assistance, government, out-of-pocket, and other private spending on health for 195 countries, 1995–2050. Lancet. 2019;393(10187):2233–2260. doi:10.1016/S0140-6736(19)30841-4 - DOI - PMC - PubMed
-
- Murthy N, Chandrasekharan S, Prakash MP, et al. The Impact of an mHealth voice message service (mMitra) on infant care knowledge, and practices among low-income women in india: findings from a pseudo-randomized controlled trial. Matern Child Health J. 2019;23(12):1658–1669. doi:10.1007/s10995-019-02805-5 - DOI - PMC - PubMed
-
- Maneze D, Weaver R, Kovai V, et al. “Some say no, some say yes”: receiving inconsistent or insufficient information from healthcare professionals and consequences for diabetes self-management: A qualitative study in patients with Type 2 Diabetes. Diabetes Res Clin Pract. 2019;156(107830):107830. doi:10.1016/j.diabres.2019.107830 - DOI - PubMed
-
- Islam SM, Tabassum R, Liu Y, et al. The role of social media in preventing and managing non-communicable diseases in low-and-middle income countries: hope or hype? Health Policy Technol. 2019;8(1):96–101. doi:10.1016/j.hlpt.2019.01.001 - DOI
-
- Ristau RA, Yang J, White JR. Evaluation and evolution of diabetes mobile applications: key factors for health care professionals seeking to guide patients. Diabetes Spectr. 2013;26(4):211–215. doi:10.2337/diaspect.26.4.211 - DOI
-
- mHealth: new horizons for health through mobile technologies [homepage on the internet]. World Health Organisation. Available from: https://www.who.int/goe/publications/goe_mhealth_web.pdf. Accessed November6, 2019.
-
- Joshi A, Rane M, Roy D, et al. Supporting treatment of people living with HIV/AIDS in resource limited settings with IVRs. Proceedings of the SIGCHI Conference on Human Factors in Computing Systems; April 2014; Toronto, Ontario, Canada.
-
- Mohiuddin AK. Diabetes fact: Bangladesh perspective. Int J Diabetes Res. 2019;2(1):14–20.
-
- Prevalence of tobacco smoking [homepage on the internet]. World Health Organization. Available from: https://www.who.int/gho/tobacco/use/en/. Accessed February17, 2020.
-
- Escobar ER, Gamino MN, Salazar RM, et al. National trends in alcohol consumption in Mexico: results of the National Survey on Drug, Alcohol and Tobacco Consumption 2016–2017. Salud Ment. 2018;41(1):7–16.
-
- Shamah-Levy T, Romero-Martínez M, Cuevas-Nasu L, Méndez Gómez-Humaran IM, Antonio Avila-Arcos M, Rivera-Dommarco JA. The Mexican National Health and Nutrition Survey as a Basis for Public Policy Planning: overweight and Obesity. Nutrients. 2019;11(8):1727. doi:10.3390/nu11081727 - DOI - PMC - PubMed