Association of CNS demyelination and COVID-19 infection: an updated systematic review

Ismail Ibrahim Ismail # 1, Sara Salama # 2

Affiliations

01 February 2022

-

doi: 10.1007/s00415-021-10752-x

Abstract

Background: Since the declaration of COVID-19 pandemic, several case reports of demyelination of both peripheral and central nervous systems have been published. The association between CNS demyelination and viral infection has long been documented, and this link was recently reported following SARS-CoV-2 infection as well.

Objectives: In this systematic review, we aim to investigate the existing literature on CNS demyelination associated with SARS-CoV-2, and the proposed pathophysiological mechanisms.

Methods: We conducted a systematic review of articles in PubMed, SCOPUS, EMBASE, Cochrane, Google Scholar and Ovid databases, from 1 January 2020 until June 15, 2021. The following keywords were used: "COVID-19", "SARS-CoV-2", "demyelination", "demyelinating disease", "multiple sclerosis", "neuromyelitis optica", and "transverse myelitis".

Results: A total of 60 articles were included in the final analysis of this systematic review and included 102 patients: 52 (51%) men and 50 (49%) women, with a median age of 46.5 years. The demyelination mimicked a variety of conditions with a picture of encephalitis/encephalomyelitis being the most common. At the same time other patterns were less frequently reported such as MS, NMOSD and even MOGAD. Longitudinally extensive transverse myelitis (LETM) was the most frequently reported pattern of spinal cord involvement.

Conclusion: A growing body of literature has shown an association between SARS-CoV-2 infection and the development of different types of CNS demyelination. Although causality cannot readily be inferred, this review may suggest a probable causal relationship, through a para-infectious or post-infectious immune-mediated etiology in COVID-19 patients. This relationship needs to be clarified in future research.

Keywords: COVID-19; Demyelinating disease; Multiple sclerosis; SARS-CoV-2.

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

  1.  
    1. Andalib S, Biller J, Di Napoli M, Moghimi N, McCullough LD, Rubinos CA, et al. Peripheral nervous system manifestations associated with COVID-19. Curr Neurol Neurosci Rep. 2021;21(3):9. doi: 10.1007/s11910-021-01102-5. - DOI - PMC - PubMed
  2.  
    1. Montalvan V, Lee J, Bueso T, De Toledo J, Rivas K. Neurological manifestations of COVID-19 and other coronavirus infections: a systematic review. Clin Neurol Neurosurg. 2020;194:105921. doi: 10.1016/j.clineuro.2020.105921. - DOI - PMC - PubMed
  3.  
    1. Paterson RW, Brown RL, Benjamin L, Nortley R, Wiethoff S, Bharucha T, et al. The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings. Brain. 2020;143(10):3104–3120. doi: 10.1093/brain/awaa240. - DOI - PMC - PubMed
  4.  
    1. Corrêa DG, de Souza Lima FC, da Cruz Bezerra D, Coutinho AC, Hygino da Cruz LC. COVID-19 associated with encephalomyeloradiculitis and positive anti-aquaporin-4 antibodies: cause or coincidence? Mult Scler. 2021;27(6):973–976. doi: 10.1177/1352458520949988. - DOI - PubMed
  5.  
    1. Yavari F, Raji S, Moradi F, Saeidi M. Demyelinating changes alike to multiple sclerosis: a case report of rare manifestations of COVID-19. In: Banerjee TK, editor. Case reports in neurological medicine. London: Hindawi; 2020. pp. 1–4. - PMC - PubMed
  6.  
    1. Mahalakshmi AM, Ray B, Tuladhar S, Bhat A, Paneyala S, Patteswari D, et al. Does COVID-19 contribute to development of neurological disease? Immun Inflamm Dis. 2021;9(1):48–58. doi: 10.1002/iid3.387. - DOI - PMC - PubMed
  7.  
    1. Gu J, Gong E, Zhang B, Zheng J, Gao Z, Zhong Y, et al. Multiple organ infection and the pathogenesis of SARS. J Exp Med. 2005;202(3):415–424. doi: 10.1084/jem.20050828. - DOI - PMC - PubMed
  8.  
    1. Ann Yeh E, Collins A, Cohen ME, Duffner PK, Faden H. Detection of coronavirus in the central nervous system of a child with acute disseminated encephalomyelitis. Pediatrics. 2004;113(1):e73–e76. doi: 10.1542/peds.113.1.e73. - DOI - PubMed
  9.  
    1. Verstrepen K, Baisier L, De Cauwer H. Neurological manifestations of COVID-19, SARS and MERS. Acta Neurol Belg. 2020;120(5):1051–1060. doi: 10.1007/s13760-020-01412-4. - DOI - PMC - PubMed
  10.  
    1. Desforges M, Le Coupanec A, Dubeau P, Bourgouin A, Lajoie L, Dubé M, et al. Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? Viruses. 2019;12(1):14. doi: 10.3390/v12010014. - DOI - PMC - PubMed
  11.  
    1. Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L, et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020;87:18–22. doi: 10.1016/j.bbi.2020.03.031. - DOI - PMC - PubMed
  12.  
    1. Moore L, Ghannam M, Manousakis G. A first presentation of multiple sclerosis with concurrent COVID-19 infection. eNeurologicalSci. 2021;22:100299. doi: 10.1016/j.ensci.2020.100299. - DOI - PMC - PubMed
  13.  
    1. Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, et al. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology. 2015;85(2):177–189. doi: 10.1212/WNL.0000000000001729. - DOI - PMC - PubMed
  14.  
    1. Zoghi A, Ramezani M, Roozbeh M, Darazam IA, Sahraian MA. A case of possible atypical demyelinating event of the central nervous system following COVID-19. Mult Scler Relat Disord. 2020;44:102324. doi: 10.1016/j.msard.2020.102324. - DOI - PMC - PubMed
  15.  
    1. Perlman S, Zhao J. Roles of regulatory T cells and IL-10 in virus-induced demyelination. J Neuroimmunol. 2017;15(308):6–11. doi: 10.1016/j.jneuroim.2017.01.001. - DOI - PMC - PubMed
  16.  
    1. Murray RS, Cai GY, Hoel K, Zhang JY, Soike KF, Cabirac GF. Coronavirus infects and causes demyelination in primate central nervous system. Virology. 1992;188(1):274–284. doi: 10.1016/0042-6822(92)90757-G. - DOI - PMC - PubMed
  17.  
    1. Talbot PJ, Boucher A, Duquette P, Gruslin E (2005) Coronaviruses and neuroantigens: myelin proteins, myelin genes. In: Lavi E, Constantinescu CS (eds) Experimental models of multiple sclerosis [Internet]. Springer US, Boston [cited 2021 Jul 1], pp 781–791. 10.1007/0-387-25518-4_43
  18.  
    1. Lima M, Siokas V, Aloizou A-M, Liampas I, Mentis A-FA, Tsouris Z, et al. Unraveling the possible routes of SARS-COV-2 invasion into the central nervous system. Curr Treat Options Neurol. 2020;22(11):37. doi: 10.1007/s11940-020-00647-z. - DOI - PMC - PubMed
  19.  
    1. Han H, Ma Q, Li C, Liu R, Zhao L, Wang W, et al. Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors. Emerg Microbes Infect. 2020;9(1):1123–1130. doi: 10.1080/22221751.2020.1770129. - DOI - PMC - PubMed
  20.  
    1. Petkovic F, Castellano B. The role of interleukin-6 in central nervous system demyelination. Neural Regen Res. 2016;11(12):1922. doi: 10.4103/1673-5374.195273. - DOI - PMC - PubMed
  21.  
    1. Janssens K, Slaets H, Hellings N. Immunomodulatory properties of the IL-6 cytokine family in multiple sclerosis. Ann N Y Acad Sci. 2015;1351:52–60. doi: 10.1111/nyas.12821. - DOI - PubMed
  22.  
    1. Cao X. COVID-19: immunopathology and its implications for therapy. Nat Rev Immunol. 2020;20(5):269–270. doi: 10.1038/s41577-020-0308-3. - DOI - PMC - PubMed
  23.  
    1. Kostic M, Dzopalic T, Zivanovic S, Zivkovic N, Cvetanovic A, Stojanovic I, et al. IL-17 and glutamate excitotoxicity in the pathogenesis of multiple sclerosis. Scand J Immunol. 2014;79(3):181–186. doi: 10.1111/sji.12147. - DOI - PubMed
  24.  
    1. Matschke J, Lütgehetmann M, Hagel C, Sperhake JP, Schröder AS, Edler C, et al. Neuropathology of patients with COVID-19 in Germany: a post-mortem case series. Lancet Neurol. 2020;19(11):919–929. doi: 10.1016/S1474-4422(20)30308-2. - DOI - PMC - PubMed
  25.  
    1. Racke MK, Drew PD (2009) Toll-like receptors in multiple sclerosis. In: Kielian T (ed) Toll-like receptors: roles in infection and neuropathology [Internet]. Springer, Berlin [cited 2021 Jul 1], pp 155–168 (Current Topics in Microbiology and Immunology; vol 336). 10.1007/978-3-642-00549-7_9 - PMC - PubMed
  26.  
    1. Khanmohammadi S, Rezaei N. Role of Toll-like receptors in the pathogenesis of COVID-19. J Med Virol. 2021;93(5):2735–2739. doi: 10.1002/jmv.26826. - DOI - PMC - PubMed
  27.  
    1. Kamel WA, Ibrahim Ismail I, Al-Hashel JY. Guillain–Barre syndrome following COVID-19 infection: first case report from Kuwait and review of the literature. Dubai Med J. 2021;18:1–5.
  28.  
    1. Feldstein LR, Rose EB, Horwitz SM, Collins JP, Newhams MM, Son MBF, et al. Multisystem inflammatory syndrome in U.S. children and adolescents. N Engl J Med. 2020;383(4):334–346. doi: 10.1056/NEJMoa2021680. - DOI - PMC - PubMed
  29.  
    1. Lindan CE, Mankad K, Ram D, Kociolek LK, Silvera VM, Boddaert N, et al. Neuroimaging manifestations in children with SARS-CoV-2 infection: a multinational, multicentre collaborative study. Lancet Child Adolesc Health. 2021;5(3):167–177. doi: 10.1016/S2352-4642(20)30362-X. - DOI - PMC - PubMed
  30.  
    1. Stafstrom CE, Jantzie LL. COVID-19: neurological considerations in neonates and children. Children (Basel) 2020;7(9):E133. - PMC - PubMed
  31.  
    1. Sotgiu S, Uzzau S, Pippia A, Carta A, Antonucci R. Expanding the spectrum of acute cerebellitis due to SARS-Cov-2. Pediatr Neurol. 2021;121:1–2. doi: 10.1016/j.pediatrneurol.2021.05.007. - DOI - PMC - PubMed
  32.  
    1. Zanin L, Saraceno G, Panciani PP, Renisi G, Signorini L, Migliorati K, et al. SARS-CoV-2 can induce brain and spine demyelinating lesions. Acta Neurochir. 2020;162(7):1491–1494. doi: 10.1007/s00701-020-04374-x. - DOI - PMC - PubMed
  33.  
    1. Brun G, Hak J-F, Coze S, Kaphan E, Carvelli J, Girard N, et al. COVID-19—white matter and globus pallidum lesions: demyelination or small-vessel vasculitis? Neurol Neuroimmunol Neuroinflamm. 2020;7(4):e777. doi: 10.1212/NXI.0000000000000777. - DOI - PMC - PubMed
  34.  
    1. Alqwaifly M. Demyelinating solitary lesion of the central nervous system associated with COVID-19: a case report and literature review. Int J Adv Med. 2020;7(12):1884. doi: 10.18203/2349-3933.ijam20204998. - DOI
  35.  
    1. Poyiadji N, Shahin G, Noujaim D, Stone M, Patel S, Griffith B. COVID-19-associated acute hemorrhagic necrotizing encephalopathy: imaging features. Radiology. 2020;296(2):E119–E120. doi: 10.1148/radiol.2020201187. - DOI - PMC - PubMed
  36.  
    1. Varadan B, Shankar A, Rajakumar A, Subramanian S, Sathya AC, Hakeem AR, et al. Acute hemorrhagic leukoencephalitis in a COVID-19 patient—a case report with literature review. Neuroradiology. 2021;63(5):653–661. doi: 10.1007/s00234-021-02667-1. - DOI - PMC - PubMed
  37.  
    1. Yong MH, Chan YFZ, Liu J, Sanamandra SK, Kheok SW, Lim KC, et al. A rare case of acute hemorrhagic leukoencephalitis in a COVID-19 patient. J Neurol Sci. 2020;416:117035. doi: 10.1016/j.jns.2020.117035. - DOI - PMC - PubMed
  38.  
    1. Chalil A, Baker CS, Johnston RB, Just C, Debicki DB, Mayich MS, et al. Acute hemorrhagic encephalitis related to COVID-19. Neurol Clin Pract. 2021;11(2):e147–e151. doi: 10.1212/CPJ.0000000000000900. - DOI - PMC - PubMed
  39.  
    1. Karapanayiotides T, Geka E, Prassopoulos P, Koutroulou I, Kollaras P, Kiourtzieva E, et al. Concentric demyelination pattern in COVID-19-associated acute haemorrhagic leukoencephalitis: a lurking catastrophe? Brain. 2020;143(12):e100. doi: 10.1093/brain/awaa375. - DOI - PMC - PubMed
  40.  
    1. Handa R, Nanda S, Prasad A, Anand R, Zutshi D, Dass SK, et al. Covid-19-associated acute haemorrhagic leukoencephalomyelitis. Neurol Sci. 2020;41(11):3023–3026. doi: 10.1007/s10072-020-04703-z. - DOI - PMC - PubMed
  41.  
    1. Ghosh R, Dubey S, Finsterer J, Chatterjee S, Ray BK (2020) SARS-CoV-2-associated acute hemorrhagic, necrotizing encephalitis (AHNE) presenting with cognitive impairment in a 44-year-old woman without comorbidities: a case report. Am J Case Rep [Internet] [cited 2021 Jun 30]. https://www.amjcaserep.com/abstract/index/idArt/925641 - PMC - PubMed
  42.  
    1. Haqiqi A, Samuels TL, Lamb FJ, Moharrum T, Myers AE. Acute haemorrhagic leukoencephalitis (Hurst disease) in severe COVID-19 infection. Brain Behav Immun Health. 2021;12:100208. doi: 10.1016/j.bbih.2021.100208. - DOI - PMC - PubMed
  43.  
    1. Mullaguri N, Sivakumar S, Battineni A, Anand S, Vanderwerf J (2021) COVID-19 related acute hemorrhagic necrotizing encephalitis: a report of two cases and literature review. Cureus [Internet] [cited 2021 Jun 30]. https://www.cureus.com/articles/50440-covid-19-related-acute-hemorrhagic... - PMC - PubMed
  44.  
    1. Radmanesh A, Derman A, Lui YW, Raz E, Loh JP, Hagiwara M, et al. COVID-19-associated diffuse leukoencephalopathy and microhemorrhages. Radiology. 2020;297(1):E223–E227. doi: 10.1148/radiol.2020202040. - DOI - PMC - PubMed
  45.  
    1. Sachs JR, Gibbs KW, Swor DE, Sweeney AP, Williams DW, Burdette JH, et al. COVID-19-associated leukoencephalopathy. Radiology. 2020;296(3):E184–E185. doi: 10.1148/radiol.2020201753. - DOI - PMC - PubMed
  46.  
    1. McLendon LA, Rao CK, Da Hora CC, Islamovic F, Galan FN. Post-COVID-19 acute disseminated encephalomyelitis in a 17-month-old. Pediatrics. 2021;147(6):e2020049678. doi: 10.1542/peds.2020-049678. - DOI - PubMed
  47.  
    1. Scullen T, Keen J, Mathkour M, Dumont AS, Kahn L. Coronavirus 2019 (COVID-19)-associated encephalopathies and cerebrovascular disease: the New Orleans Experience. World Neurosurg. 2020;141:e437–e446. doi: 10.1016/j.wneu.2020.05.192. - DOI - PMC - PubMed
  48.  
    1. Virhammar J, Kumlien E, Fällmar D, Frithiof R, Jackmann S, Sköld MK, et al. Acute necrotizing encephalopathy with SARS-CoV-2 RNA confirmed in cerebrospinal fluid. Neurology. 2020;95(10):445–449. doi: 10.1212/WNL.0000000000010250. - DOI - PMC - PubMed
  49.  
    1. Dixon L, Varley J, Gontsarova A, Mallon D, Tona F, Muir D, et al. COVID-19-related acute necrotizing encephalopathy with brain stem involvement in a patient with aplastic anemia. Neurol Neuroimmunol Neuroinflamm. 2020;7(5):e789. doi: 10.1212/NXI.0000000000000789. - DOI - PMC - PubMed
  50.  
    1. Montes-Ramirez J, Aquino-Lopez E. COVID-19-associated diffuse leukoencephalopathy and cerebral microbleeds during puerperium. Int J Gynecol Obstet. 2020;151(3):466–467. doi: 10.1002/ijgo.13399. - DOI - PubMed
  51.  
    1. McCuddy M, Kelkar P, Zhao Y, Wicklund D. Acute demyelinating encephalomyelitis (ADEM) in COVID-19 infection: a case series. Neurol India. 2020;68(5):1192–1195. - PubMed
  52.  
    1. Assunção FB, Fragoso DC, Donoso Scoppetta TLP, Martins Maia AC. COVID-19-associated acute disseminated encephalomyelitis-like disease. AJNR Am J Neuroradiol. 2021;42(4):E21–E23. doi: 10.3174/ajnr.A6967. - DOI - PMC - PubMed
  53.  
    1. Parsons T, Banks S, Bae C, Gelber J, Alahmadi H, Tichauer M. COVID-19-associated acute disseminated encephalomyelitis (ADEM) J Neurol. 2020;267(10):2799–2802. doi: 10.1007/s00415-020-09951-9. - DOI - PMC - PubMed
  54.  
    1. Langley L, Zeicu C, Whitton L, Pauls M. Acute disseminated encephalomyelitis (ADEM) associated with COVID-19. BMJ Case Rep. 2020;13(12):e239597. doi: 10.1136/bcr-2020-239597. - DOI - PMC - PubMed
  55.  
    1. Wong PF, Craik S, Newman P, Makan A, Srinivasan K, Crawford E, et al. Lessons of the month 1: a case of rhombencephalitis as a rare complication of acute COVID-19 infection. Clin Med. 2020;20(3):293–294. doi: 10.7861/clinmed.2020-0182. - DOI - PMC - PubMed
  56.  
    1. Novi G, Rossi T, Pedemonte E, Saitta L, Rolla C, Roccatagliata L, et al. Acute disseminated encephalomyelitis after SARS-CoV-2 infection. Neurol Neuroimmunol Neuroinflamm. 2020;7(5):e797. doi: 10.1212/NXI.0000000000000797. - DOI - PMC - PubMed
  57.  
    1. Demirci Otluoglu G, Yener U, Demir MK, Yilmaz B. Encephalomyelitis associated with Covid-19 infection: case report. Br J Neurosurg. 2020;7:1–3. - PubMed
  58.  
    1. Utukuri PS, Bautista A, Lignelli A, Moonis G. Possible acute disseminated encephalomyelitis related to severe acute respiratory syndrome coronavirus 2 infection. AJNR Am J Neuroradiol. 2020;41:E82–E83. - PMC - PubMed
  59.  
    1. Lopes CCB, Brucki SMD, Passos Neto CEB, Corazza LA, Baima JPS, Fiorentino MD, et al. Acute disseminated encephalomyelitis in COVID-19: presentation of two cases and review of the literature. Arq Neuro-Psiquiatr. 2020;78(12):805–810. doi: 10.1590/0004-282x20200186. - DOI - PubMed
  60.  
    1. Kim HJ, Paul F, Lana-Peixoto MA, Tenembaum S, Asgari N, Palace J, et al. MRI characteristics of neuromyelitis optica spectrum disorder: an international update. Neurology. 2015;84(11):1165–1173. doi: 10.1212/WNL.0000000000001367. - DOI - PMC - PubMed
  61.  
    1. de Ruijter NS, Kramer G, Gons RAR, Hengstman GJD. Neuromyelitis optica spectrum disorder after presumed coronavirus (COVID-19) infection: a case report. Mult Scler Relat Disord. 2020;46:102474. doi: 10.1016/j.msard.2020.102474. - DOI - PMC - PubMed
  62.  
    1. Zhou S, Jones-Lopez EC, Soneji DJ, Azevedo CJ, Patel VR. Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis and myelitis in COVID-19. J Neuroophthalmol. 2020;40(3):398–402. doi: 10.1097/WNO.0000000000001049. - DOI - PMC - PubMed
  63.  
    1. Kogure C, Kikushima W, Fukuda Y, Hasebe Y, Takahashi T, Shibuya T, et al. Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis in a COVID-19 patient: a case report. Medicine. 2021;100(19):e25865. doi: 10.1097/MD.0000000000025865. - DOI - PMC - PubMed
  64.  
    1. Valiuddin H, Skwirsk B, Paz-Arabo P. Acute transverse myelitis associated with SARS-CoV-2: a case-report. Brain Behav Immun Health. 2020;5:100091. doi: 10.1016/j.bbih.2020.100091. - DOI - PMC - PubMed
  65.  
    1. Moreno-Escobar MC, Kataria S, Khan E, Subedi R, Tandon M, Peshwe K, et al. Acute transverse myelitis with dysautonomia following SARS-CoV-2 infection: a case report and review of literature. J Neuroimmunol. 2021;353:577523. doi: 10.1016/j.jneuroim.2021.577523. - DOI - PMC - PubMed
  66.  
    1. Munz M, Wessendorf S, Koretsis G, Tewald F, Baegi R, Krämer S, et al. Acute transverse myelitis after COVID-19 pneumonia. J Neurol. 2020;267(8):2196–2197. doi: 10.1007/s00415-020-09934-w. - DOI - PMC - PubMed
  67.  
    1. Sarma D, Bilello L. A case report of acute transverse myelitis following novel coronavirus infection. Clin Pract Cases Emerg Med. 2020;4(3):321–323. doi: 10.5811/cpcem.2020.5.47937. - DOI - PMC - PubMed
  68.  
    1. Sotoca J, Rodríguez-Álvarez Y. COVID-19-associated acute necrotizing myelitis. Neurol Neuroimmunol Neuroinflamm. 2020;7(5):e803. doi: 10.1212/NXI.0000000000000803. - DOI - PMC - PubMed
  69.  
    1. Domingues RB, Mendes-Correa MC, de Moura Leite FBV, Sabino EC, Salarini DZ, Claro I, et al. First case of SARS-COV-2 sequencing in cerebrospinal fluid of a patient with suspected demyelinating disease. J Neurol. 2020;267(11):3154–3156. doi: 10.1007/s00415-020-09996-w. - DOI - PMC - PubMed
  70.  
    1. AlKetbi R, AlNuaimi D, AlMulla M, AlTalai N, Samir M, Kumar N, et al. Acute myelitis as a neurological complication of Covid-19: a case report and MRI findings. Radiol Case Rep. 2020;15(9):1591–1595. doi: 10.1016/j.radcr.2020.06.001. - DOI - PMC - PubMed
  71.  
    1. Durrani M, Kucharski K, Smith Z, Fien S. Acute transverse myelitis secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a case report. Clin Pract Cases Emerg Med. 2020;4(3):344–348. doi: 10.5811/cpcem.2020.6.48462. - DOI - PMC - PubMed
  72.  
    1. Chow CCN, Magnussen J, Ip J, Su Y. Acute transverse myelitis in COVID-19 infection. BMJ Case Rep. 2020;13(8):e236720. doi: 10.1136/bcr-2020-236720. - DOI - PMC - PubMed
  73.  
    1. Kaur H, Mason JA, Bajracharya M, McGee J, Gunderson MD, Hart BL, et al. Transverse myelitis in a child with COVID-19. Pediatr Neurol. 2020;112:5–6. doi: 10.1016/j.pediatrneurol.2020.07.017. - DOI - PMC - PubMed
  74.  
    1. Masuccio FG, Barra M, Claudio G, Claudio S. A rare case of acute motor axonal neuropathy and myelitis related to SARS-CoV-2 infection. J Neurol. 2021;268(7):2327–2330. doi: 10.1007/s00415-020-10219-5. - DOI - PMC - PubMed
  75.  
    1. Shahali H, Ghasemi A, Farahani RH, Nezami Asl A, Hazrati E. Acute transverse myelitis after SARS-CoV-2 infection: a rare complicated case of rapid onset paraplegia. J Neurovirol. 2021;27(2):354–358. doi: 10.1007/s13365-021-00957-1. - DOI - PMC - PubMed
  76.  
    1. Chakraborty U, Chandra A, Ray AK, Biswas P. COVID-19-associated acute transverse myelitis: a rare entity. BMJ Case Rep. 2020;13(8):e238668. doi: 10.1136/bcr-2020-238668. - DOI - PMC - PubMed
  77.  
    1. Baghbanian SM, Namazi F (2020) Post COVID-19 longitudinally extensive transverse myelitis (LETM)–a case report. Acta Neurol Belg [Internet] [cited 2021 Jul 1]. 10.1007/s13760-020-01497-x - PMC - PubMed
  78.  
    1. Guler MA, Keskin F, Tan H. Acute myelitis secondary to COVID-19 in an adolescent: causality or coincidence? New Trend Med Sci. 2020;1(2):132–136.
  79.  
    1. Fumery T, Baudar C, Ossemann M, London F. Longitudinally extensive transverse myelitis following acute COVID-19 infection. Mult Scler Relat Disord. 2021;48:102723. doi: 10.1016/j.msard.2020.102723. - DOI - PMC - PubMed
  80.  
    1. Nejad Biglari H, Sinaei R, Pezeshki S, Khajeh HF. Acute transverse myelitis of childhood due to novel coronavirus disease 2019: The first pediatric case report and review of literature. Iran J Child Neurol. 2021;15(1):107–112. - PMC - PubMed
  81.  
    1. Ali L, Khan A, Elalamy O, Canibano B, Al hatou M, Adeli G, Ahmed I, Iqrar A, Abdussalam A, Ibrahim AS, Sardar S (2020) A rare presentation of acute flaccid myelitis in COVID-19 patient: a case report. Pak J Neurol Sci (PJNS) 15(3), Article 5
  82.  
    1. Román GC, Gracia F, Torres A, Palacios A, Gracia K, Harris D. Acute transverse myelitis (ATM): clinical review of 43 patients with COVID-19-associated ATM and 3 post-vaccination ATM serious adverse events with the ChAdOx1 nCoV-19 vaccine (AZD1222) Front Immunol. 2021;12:653786. doi: 10.3389/fimmu.2021.653786. - DOI - PMC - PubMed
  83.  
    1. Saberi A, Ghayeghran A, Hatamian H, et al. COVID-19-associated myelitis, para/post infectious or infectious myelitis: a case report from the north of Iran. Caspian J Neurol Sci. 2020;6(2):132–138. doi: 10.32598/CJNS.6.21.1. - DOI

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