Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelos Evangelou 1 2Helen R Warren 3 4David Mosen-Ansorena 1Borbala Mifsud 3Raha Pazoki 1He Gao 1 5Georgios Ntritsos 2Niki Dimou 2Claudia P Cabrera 3 4Ibrahim Karaman 1Fu Liang Ng 3Marina Evangelou 1 6Katarzyna Witkowska 3Evan Tzanis 3Jacklyn N Hellwege 7Ayush Giri 8Digna R Velez Edwards 8Yan V Sun 9 10Kelly Cho 11 12J Michael Gaziano 11 12Peter W F Wilson 13Philip S Tsao 14Csaba P Kovesdy 15Tonu Esko 16 17Reedik Mägi 16Lili Milani 16Peter Almgren 18Thibaud Boutin 19Stéphanie Debette 20 21Jun Ding 22Franco Giulianini 23Elizabeth G Holliday 24Anne U Jackson 25Ruifang Li-Gao 26Wei-Yu Lin 27Jian'an Luan 28Massimo Mangino 29 30Christopher Oldmeadow 24Bram Peter Prins 31Yong Qian 22Muralidharan Sargurupremraj 21Nabi Shah 32 33Praveen Surendran 27Sébastien Thériault 34 35Niek Verweij 17 36 37Sara M Willems 28Jing-Hua Zhao 28Philippe Amouyel 38John Connell 39Renée de Mutsert 26Alex S F Doney 32Martin Farrall 40 41Cristina Menni 29Andrew D Morris 42Raymond Noordam 43Guillaume Paré 34Neil R Poulter 44Denis C Shields 45Alice Stanton 46Simon Thom 47Gonçalo Abecasis 48Najaf Amin 49Dan E Arking 50Kristin L Ayers 51 52Caterina M Barbieri 53Chiara Batini 54Joshua C Bis 55Tineka Blake 54Murielle Bochud 56Michael Boehnke 25Eric Boerwinkle 57Dorret I Boomsma 58Erwin P Bottinger 59Peter S Braund 60 61Marco Brumat 62Archie Campbell 63 64Harry Campbell 65Aravinda Chakravarti 50John C Chambers 1 5 66 67 68Ganesh Chauhan 69Marina Ciullo 70 71Massimiliano Cocca 72Francis Collins 73Heather J Cordell 51Gail Davies 74 75Martin H de Borst 76Eco J de Geus 58Ian J Deary 74 75Joris Deelen 77Fabiola Del Greco M 78Cumhur Yusuf Demirkale 79Marcus Dörr 80 81Georg B Ehret 50 82Roberto Elosua 83 84Stefan Enroth 85A Mesut Erzurumluoglu 54Teresa Ferreira 86 87Mattias Frånberg 88 89 90Oscar H Franco 91Ilaria Gandin 62Paolo Gasparini 62 72Vilmantas Giedraitis 92Christian Gieger 93 94 95Giorgia Girotto 62 72Anuj Goel 40 41Alan J Gow 74 96Vilmundur Gudnason 97 98Xiuqing Guo 99Ulf Gyllensten 85Anders Hamsten 88 89Tamara B Harris 100Sarah E Harris 63 74Catharina A Hartman 101Aki S Havulinna 102 103Andrew A Hicks 78Edith Hofer 104 105Albert Hofman 91 106Jouke-Jan Hottenga 58Jennifer E Huffman 19 107 108Shih-Jen Hwang 107 108Erik Ingelsson 109 110Alan James 111 112Rick Jansen 113Marjo-Riitta Jarvelin 1 5 114 115 116Roby Joehanes 107 117Åsa Johansson 85Andrew D Johnson 107 118Peter K Joshi 65Pekka Jousilahti 102J Wouter Jukema 119Antti Jula 102Mika Kähönen 120 121Sekar Kathiresan 17 36 122Bernard D Keavney 123 124Kay-Tee Khaw 125Paul Knekt 102Joanne Knight 126Ivana Kolcic 127Jaspal S Kooner 5 67 68 128Seppo Koskinen 102Kati Kristiansson 102Zoltan Kutalik 56 129Maris Laan 130Marty Larson 107Lenore J Launer 100Benjamin Lehne 1Terho Lehtimäki 131 132David C M Liewald 74 75Li Lin 82Lars Lind 133Cecilia M Lindgren 40 87 134YongMei Liu 135Ruth J F Loos 28 59 136Lorna M Lopez 74 137 138Yingchang Lu 59Leo-Pekka Lyytikäinen 131 132Anubha Mahajan 40Chrysovalanto Mamasoula 139Jaume Marrugat 83Jonathan Marten 19Yuri Milaneschi 140Anna Morgan 62Andrew P Morris 40 141Alanna C Morrison 142Peter J Munson 79Mike A Nalls 143 144Priyanka Nandakumar 50Christopher P Nelson 60 61Teemu Niiranen 102 145Ilja M Nolte 146Teresa Nutile 70Albertine J Oldehinkel 147Ben A Oostra 49Paul F O'Reilly 148Elin Org 16Sandosh Padmanabhan 64 149Walter Palmas 150Aarno Palotie 103 151 152Alison Pattie 75Brenda W J H Penninx 140Markus Perola 102 103 153Annette Peters 94 95 154Ozren Polasek 127 155Peter P Pramstaller 78 156 157Quang Tri Nguyen 79Olli T Raitakari 158 159Meixia Ren 160Rainer Rettig 161Kenneth Rice 162Paul M Ridker 23 163Janina S Ried 94Harriëtte Riese 147Samuli Ripatti 103 164Antonietta Robino 72Lynda M Rose 23Jerome I Rotter 99Igor Rudan 65Daniela Ruggiero 70 71Yasaman Saba 165Cinzia F Sala 53Veikko Salomaa 102Nilesh J Samani 60 61Antti-Pekka Sarin 103Reinhold Schmidt 104Helena Schmidt 165Nick Shrine 54David Siscovick 166Albert V Smith 97 98Harold Snieder 146Siim Sõber 130Rossella Sorice 70John M Starr 74 167David J Stott 168David P Strachan 169Rona J Strawbridge 88 89Johan Sundström 133Morris A Swertz 170Kent D Taylor 99Alexander Teumer 81 171Martin D Tobin 54Maciej Tomaszewski 123 124Daniela Toniolo 53Michela Traglia 53Stella Trompet 119 172Jaakko Tuomilehto 173 174 175 176Christophe Tzourio 21André G Uitterlinden 91 177Ahmad Vaez 146 178Peter J van der Most 146Cornelia M van Duijn 49Anne-Claire Vergnaud 1Germaine C Verwoert 91Veronique Vitart 19Uwe Völker 81 179Peter Vollenweider 180Dragana Vuckovic 62 181Hugh Watkins 40 41Sarah H Wild 182Gonneke Willemsen 58James F Wilson 19 65Alan F Wright 19Jie Yao 99Tatijana Zemunik 183Weihua Zhang 1 67John R Attia 24Adam S Butterworth 27 184Daniel I Chasman 23 163David Conen 185 186Francesco Cucca 187 188John Danesh 27 184Caroline Hayward 19Joanna M M Howson 27Markku Laakso 189Edward G Lakatta 190Claudia Langenberg 28Olle Melander 18Dennis O Mook-Kanamori 26 191Colin N A Palmer 32Lorenz Risch 192 193 194Robert A Scott 28Rodney J Scott 24Peter Sever 128Tim D Spector 29Pim van der Harst 195Nicholas J Wareham 28Eleftheria Zeggini 31Daniel Levy 107 118Patricia B Munroe 3 4Christopher Newton-Cheh 134 196 197Morris J Brown 3 4Andres Metspalu 16Adriana M Hung 198Christopher J O'Donnell 199Todd L Edwards 7Bruce M Psaty 200 201Ioanna Tzoulaki 1 2 5Michael R Barnes 3 4Louise V Wain 54 61Paul Elliott 202 203 204 205 206Mark J Caulfield 207 208Million Veteran Program

Affiliations

01 October 2018

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doi: 10.1038/s41588-018-0205-x


High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.


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