Major histocompatibility complex class II deficiency in Kuwait: clinical manifestations, immunological findings and molecular profile

Waleed Al-Herz 1, Osama Alsmadi, Motasem Melhem, Mike Recher, Francesco Frugoni, Luigi D Notarangelo

Affiliations

01 April 2013

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doi: 10.1007/s10875-012-9831-8

Abstract

Major Histocompatibility Complex (MHC) class II deficiency is a combined primary immunodeficiency disease that leads to overwhelming and recurrent infections. It was found to account for 19 % of combined immune deficiency cases in the National Primary Immunodeficiency Disorders Registry in Kuwait, a country with high prevalence of consanguinity. We present the clinical, immunologic and molecular features of 11 Kuwaiti patients who presented with MHC class II deficiency between 2004 and 2011.

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