Kuwait Medical Electronic Library

Clinical characteristics of pediatric SARS-CoV-2 infection and coronavirus disease 2019 (COVID-19) in Kuwait

Danah Alsharrah 1, Fatemah Alhaddad 1, Munirah Alyaseen 2, Sarah Aljamaan 1, Nahar Almutairi 3, Mariam Ayed 1, Jesse Papenburg 4 5 6, Mohammad Alghounaim 7

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01 May 2021

doi: 10.1002/jmv.26684

Abstract

Clinical presentation of coronavirus disease-2019 (COVID-19) ranges from asymptomatic to severe and life-threatening. National-level registries found that children, generally, have less severe disease when compared with adults. However, most asymptomatically infected children will not present to hospital and may be missed. We aimed to describe the clinical characteristics in pediatric COVID-19 patients in Kuwait, and to estimate the potential duration of viral shedding. A retrospective cohort study was performed in Jaber Alahmad Hospital (JAH) from February 29 to April 30, 2020. During the study period and as part of the public health measures, all severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients from 1 month to 18 years old, regardless of symptoms, were hospitalized at JAH, and were included. Polymerase chain reaction (PCR) negativity was defined as having two consecutive negative PCR results from a respiratory specimen. Descriptive statistics and multivariable regression analyses were performed. We found that 67.9% (95% CI, 59.4%-75.3%) of 134 SARS-CoV-2-infected children were asymptomatic. Median PCR positivity was 15 days and did not vary with symptoms. Among patients who had laboratory investigations and chest imaging, symptomatic infection was associated with elevated C-reactive protein and procalcitonin, and radiographic pneumonia. Asymptomatic SARS-CoV-2 infection is very common in children. Among symptomatic patients, the disease seems to be mild. Children exhibit substantial duration of viral shedding, regardless of symptoms.

Keywords: SARS coronavirus

Figures

Figure 1 (A) Kaplan–Meier estimates of proportion reverse‐transcription polymerase chain reaction positive from upper respiratory specimen. (B) Median cycle threshold (Ct) value of E gene in asymptomatic and symptomatic patient. (C) Median cycle threshold (Ct) value of RdRP gene in asymptomatic and symptomatic patient

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KMEL References

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