Management of Cyclosporine-Influenced Gingival Enlargement With Azithromycin

Satish S Kumar 1, Husain Mohammad 2 3, Kian Kar 4

Affiliations

09 January 2020

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doi: 10.1002/cap.10097

Abstract

Introduction: Management of drug-influenced gingival enlargement is challenging, and surgery is most often indicated. However, because of a unique mechanism of action, azithromycin helps in the management of gingival enlargement caused by cyclosporine. An incidental observation of the effect of azithromycin in the cyclosporine-influenced gingival enlargement by physicians in 1995 led to series of basic investigations and clinical trials confirming this observation and providing a non-surgical treatment modality.

Case presentation: In this report, successful management of cyclosporine-influenced gingival enlargement in a 39-year-old renal transplant patient with the use of azithromycin without any surgical intervention is presented.

Conclusion: Use of azithromycin for managing cyclosporine-influenced gingival enlargement is a useful alternative or adjunct to surgical management. It is hoped that this report will raise further awareness of this non-surgical modality in patients taking cyclosporine.

Keywords: Azithromycin; cyclosporine; drug therapy; gingival enlargement; kidney transplantation.

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