Serum 25-hydroxyvitamin D status and wheezing in pre-school children, Kuwait

Affiliations

01 April 2019

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doi: 10.26719/emhj.18.031


Abstract

in English, Arabic, French

Background: There has been growing recognition of the critical extra-skeletal roles for vitamin D including lung disease.

Aims: This study was performed to explore the possible role of vitamin D on wheezing occurrence among Kuwaiti preschool children.

Methods: Out of 244 children from Al-Adan Hospital, Kuwait, 151 cases were enrolled as wheezers while the rest served as controls. The wheezers were subdivided into episodic wheezers (EW) and multiple trigger wheezers (MTW). Detailed history of the wheezing attacks, previous hospitalizations, and intensive care admission were recorded as well as their serum 25-hydroxyvitamin D [25(OH)D] levels.

Results: Serum 25(OH)D was significantly lower in the wheezing group, and its decrease was a risk factor for wheezing. Moreover, serum 25(OH)D was not significantly different between EW and MTW; nevertheless, its low level could be linked to MTW.

Conclusions: Vitamin D deficiency increases the risk of wheezing among preschoolers in Kuwait. A possible link between low serum 25(OH)D and MTW could highlight a specific role for vitamin D in relation to atopy. Prevention and prompt management of vitamin D deficiency should be considered among infants and children with wheezing.

Keywords: Kuwait; asthma; early wheezing; pre-school children; serum hydroxyvitamin D.


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